Kounis Syndrome: Dexketoprofen-Associated ST-Elevation Myocardial Infarction

Allergic angina and allergic myocardial infarction are common diseases associated with acute coronary syndromes and encompass a wide spectrum of mast cell activation disorders termed "Kounis Syndrome". We present here a patient with Kounis syndrome presenting with sudden cardiac arrest after intravenous infusion of dexketoprofen in the emergency room

Prognostic value of rising mean platelet volume during hospitalization in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

Abstract Background The prognostic significance of changes in mean platelet volume (MPV) during hospitalization in ST segment elevation myocardial infarction (STEMI) patients underwent primary percutaneous coronary intervention (pPCI) has not been previously evaluated. The aim of this study was to determine the association of in-hospital changes in MPV and mortality in these patients. Methods Four hundred eighty consecutive STEMI patients were enrolled in this retrospective study. The patients were grouped as survivors (n = 370) or non-survivors (n = 110). MPV at admission, and at 48–72 h was evaluated. Change in MPV (MPV at 48–72 h minus MPV on admission) was defined as ΔMPV. Results At follow-up, long-term mortality was 23%. The non-survivors had a high ΔMPV than survivors (0.37 (− 0.1–0.89) vs 0.79 (0.30–1.40) fL, p <  0.001). A high ΔMPV was an independent predictor of all cause mortality ((HR: 1.301 [1.070–1.582], p = 0.008). Morever, for long-term mortality, the AUC of a multivariable model that included age, LVEF, Killip class, and history of stroke/TIA was 0.781 (95% CI:0.731–0.832, p <  0.001). When ΔMPV was added to a multivariable model, the AUC was 0.800 (95% CI: 0.750–0.848, z = 2.256, difference p = 0.0241, Fig. 1). Also, the addition of ΔMPV to a multivariable model was associated with a significant net reclassification improvement estimated at 24.5% (p = 0.027) and an integrated discrimination improvement of 0.014 (p = 0.0198). Conclusions Rising MPV during hospitalization in STEMI patients treated with pPCI was associated with long-term mortality

Correlationship between plasma osteopontin levels and echocardiography parameters in patients with idiopathic dilated cardiomyopathy

Background: Osteopontin (OPN) has been found to be elevated in patients with heart failure (HF). The relationship between OPN and severity of HF has not been widely studied. The aim of this study was to assess correlation of plasma OPN level as a cardiac remodelling biomarker with echocardiographical parameters in patients with idiopathic dilated cardiomyopathy (DCM). Method and results: 62 patients who have idiopathic DCM were included prospectively. Plasma OPN level was determined with a commercially available human OPN enzyme immunoassay (EIA) kit according to its protocol. Echocardiographical parameters were measured according to guidelines. There was no correlation between plasma OPN levels and echocardiographical parameters, NYHA functional capacity, and BNP. Mean plasma OPN level was slightly higher in moderate to severe HF group (NYHA III-IV, n=21) than mild HF group (NYHA I-II, n=41) but it was not statistically significant (6.47±1.92 vs 6.55±2.09, p:0.935). In addition, plasma OPN levels did not show significant difference between idiopathic DCM patients with restrictive pattern and non-restrictive pattern (5.9±1.6 vs 6.72±2.05, p:0.130). Conclusion: We could not find any relation between plasma OPN levels and severity of heart failure in patients with idiopathic DCM