Continuous operation of high bit rate quantum key distribution

We demonstrate a quantum key distribution with a secure bit rate exceeding 1 Mbit/s over 50 km fiber averaged over a continuous 36-hours period. Continuous operation of high bit rates is achieved using feedback systems to control path length difference and polarization in the interferometer and the timing of the detection windows. High bit rates and continuous operation allows finite key size effects to be strongly reduced, achieving a key extraction efficiency of 96% compared to keys of infinite lengths.Comment: four pages, four figure

Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour marker

Background : Foetal antigen 2 (FA-2), first isolated in the amniotic fluid, was shown to be the circulating form of the aminopropeptide of the alpha 1 chain of procollagen type I. Serum concentrations of FA-2 appeared to be elevated in a number of disorders of bone metabolism. This paper is the first report of its role as a marker of bone metabolism in metastatic breast cancer. Methods: Serum FA-2 concentrations were measured by radioimmunoassay in 153 women with different stages of breast cancer and in 34 normal controls. Results: Serum FA-2 was significantly elevated in women with bony metastases (p < 0.015). Its levels were not significantly different among women with non-bony metastases, with non-metastatic disease, as well as among normal controls. Conclusions: FA-2 is a promising blood marker of bone metabolism. Further studies to delineate its role in the diagnosis and management of bony metastases from breast cancer are required

PERCEIVED AND INDUCED EMOTION RESPONSES TO POPULAR MUSIC: CATEGORICAL AND DIMENSIONAL MODELS

Music both conveys and evokes emotions, and although both phenomena are widely studied, the difference between them is often neglected. The purpose of this study is to examine the difference between perceived and induced emotion for western popular music using both categorical and dimensional models of emotion, and to examine the influence of individual listener differences on their emotion judgment. A total of 80 musical excerpts were randomly selected from an established dataset of 2,904 popular songs tagged with one of the four words happy, sad, angry, or relaxed on the last.fm web site. Participants listened to the excerpts and rated perceived and induced emotion on the categorical model and dimensional model, and the reliability of emotion tags was evaluated according to participants\u27 agreement with corresponding labels. In addition, the goldsmiths musical sophistication index (gold-msi) was used to assess participants\u27 musical expertise and engagement. As expected, regardless of the emotion model used, music evokes emotions similar to the emotional quality perceived in music. Moreover, emotion tags predict music emotion judgments. However, age, gender and three factors from gold-msi, importance, emotion, and music training were found not to predict listeners\u27 responses, nor the agreement with tags

Role of f02 in fluid saturation of oceanic basalt.

Assessing the conditions under which magmas become fluid-saturated has important bearings on the geochemical modelling of magmas because volatile exsolution may profoundly alter the behaviour of certain trace elements that are strongly partitioned in the coexisting fluid1. Saal et al.2 report primitive melt inclusions from dredged oceanic basalts of the Siqueiros transform fault, from which they derive volatile abundances of the depleted mantle, based on the demonstration that magmas are not fluid-saturated at their eruption depth and so preserve the mantle signature in terms of their volatile contents. However, in their analysis, Saal et al.2 consider only fluid−melt equilibria, and do not take into account the homogeneous equilibria between fluid species, which, as we show here, may lead to a significant underestimation of the pressure depth of fluid saturation

Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration

Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in mediating ethanol-related behaviours. We therefore investigated the consequences of deleting the α2-subunit on the ataxic and rewarding properties of ethanol in mice. Ataxic and sedative effects of ethanol were explored in GABA(A) α2-subunit wildtype (WT) and knockout (KO) mice using a Rotarod apparatus, wire hang and the duration of loss of righting reflex. Following training, KO mice showed shorter latencies to fall than WT littermates under ethanol (2 g/kg i.p.) in both Rotarod and wire hang tests. After administration of ethanol (3.5 g/kg i.p.), KO mice took longer to regain the righting reflex than WT mice. To ensure the acute effects are not due to the gabra2 deletion affecting pharmacokinetics, blood ethanol concentrations were measured at 20 minute intervals after acute administration (2 g/kg i.p.), and did not differ between genotypes. To investigate ethanol's rewarding properties, WT and KO mice were trained to lever press to receive increasing concentrations of ethanol on an FR4 schedule of reinforcement. Both WT and KO mice self-administered ethanol at similar rates, with no differences in the numbers of reinforcers earned. These data indicate a protective role for α2-subunits, against the acute sedative and ataxic effects of ethanol. However, no change was observed in ethanol self administration, suggesting the rewarding effects of ethanol remain unchange

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats

Tertiary hypothyroidism in a dog

<p/> <p>A nine-year-old male entire Labrador was diagnosed with pituitary dependent hyperadrenocorticism. Following seven months of successful mitotane therapy, the dog presented with marked weight gain, seborrhoea and alopecia. Routine clinicopathological analyses revealed marked hypercholesterolaemia. Serum total and free thyroxine (T4) concentrations were below their respective reference ranges. Serum thyroid stimulating hormone (cTSH) concentration was within reference range. TSH and thyrotropin releasing hormone (TRH) response tests revealed adequate stimulation of total T4 in both, and cTSH in the latter test. Magnetic resonance imaging revealed a mass arising from the pituitary fossa, with suprasellar extension. A diagnosis of tertiary hypothyroidism was made. Following four weeks of levothyroxine therapy, circulating cholesterol concentration had declined, weight loss had ensued and dermatological abnormalities had improved. Euthanasia was performed four months later due to the development of neurological signs. A highly infiltrative pituitary adenoma, with effacement of the overlying hypothalamus was identified on post mortem examination. Tertiary hypothyroidism has not been previously reported in dogs.</p

Evaluation of injectable nucleus augmentation materials for the treatment of intervertebral disc degeneration

Back pain affects a person's health and mobility as well as being associated with large health and social costs. Lower back pain is frequently caused by degeneration of the intervertebral disc. Current operative and non-operative treatments are often ineffective and expensive. Nucleus augmentation is designed to be a minimally invasive method of restoring the disc to its native healthy state by restoring the disc height, and mechanical and/or biological properties. The majority of the candidate materials for nucleus augmentation are injectable hydrogels. In this review, we examine the materials that are currently under investigation for nucleus augmentation, and compare their ability to meet the design requirements for this application. Specifically, the delivery of the material into the disc, the mechanical properties of the material and the biological compatibility are examined. Recommendations for future testing are also made

Moduli Stabilisation in Heterotic Models with Standard Embedding

In this note we analyse the issue of moduli stabilisation in 4d models obtained from heterotic string compactifications on manifolds with SU(3) structure with standard embedding. In order to deal with tractable models we first integrate out the massive fields. We argue that one can not only integrate out the moduli fields, but along the way one has to truncate also the corresponding matter fields. We show that the effective models obtained in this way do not have satisfactory solutions. We also look for stabilised vacua which take into account the presence of the matter fields. We argue that this also fails due to a no-go theorem for Minkowski vacua in the moduli sector which we prove in the end. The main ingredient for this no-go theorem is the constraint on the fluxes which comes from the Bianchi identity.Comment: 20 pages, LaTeX; references adde