Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential

Background: Little justification is generally provided for selection of in vitro assay testing concentrations for engineered nanomaterials (ENMs). Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable

Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals

Background: Over the past 20 years, an increased focus on detecting environmental chemicals that pose a risk of adverse effects due to endocrine disruption has driven the creation of the U.S. Environmental Protection Agency (EPA) Endocrine Disruptor Screening Program (EDSP). Thousands of chemicals are subject to the EDSP; thus, processing these chemicals using current test batteries could require millions of dollars and decades. A need for increased throughput and efficiency motivated the development of methods using in vitro high throughput screening (HTS) assays to prioritize chemicals for EDSP Tier 1 screening (T1S)

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

Summary In vitro high-throughput screening (HTS

Exploring the utility of remote messaging and situated office door displays

In recent years, the proliferation in use of the GSM short message service (or SMS) has prompted numerous studies into person to person messaging via mobile devices. However, to date, there has been relatively little exploration of systems that enable mobile messaging to (potentially ubiquitous) situated displays rather than the mobile devices of particular individuals. In this paper, we describe the results of an ongoing trial to explore the utility of a system that enables lecturers in a computing department to use their mobile phones to send messages to digital displays situated outside their offices

Exploring awareness related messaging through two situated-display-based systems.

This article focuses on our exploration of awareness issues through the design and long-term deployment of two systems: the Hermes office door display system (which enabled staff in a university department to post awareness messages to their door displays) and SPAM (a messaging system for supporting coordination between staff at two associated residential community care facilities). In the case of both systems, a significant number of the messages sent could be classified as relating to awareness. Furthermore, with both systems, the situatedness of displays (outside office doors in the case of Hermes and in staff offices in the case of SPAM) had a significant impact on the design and subsequent use of the deployed systems. In particular, the placement of displays provided significant context for awareness messages, including, for example, the identity of the sender of the message and the intended audience of the message. Both systems highlight the need for interaction methods that fit in with both normal working practices (and unplanned events) and that enable the user to manage communication channels. The need for appropriate levels of expressiveness and user control is also apparent: We present numerous examples of users controlling the precision of awareness information and sending awareness messages that have as much to do with playfulness as supporting coordination through activity awareness

The Co-realisation of a Village Photo Display

We describe the techniques used to evaluate the potential of situated photo displays in supporting notions of community in a rural village. Through a combination of ethnography, technology probe deployments and a design workshop, we have deployed and evaluated a successful prototype display