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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel JakĆĄa
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- BarĆĄiÄ Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- BĂ©lteczki JĂĄnos
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ăve
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- CĂĄrcel FernĂĄndez Sheila
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau CĂ©dric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
- Detry Michelle
- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
- Dragija Lidija
- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
- Duncan Tracey
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- DâAragon FrĂ©dĂ©rick
- DâSouza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- English Shane
- Estcourt Lise
- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
- Farahi Neda
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ăgnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- FernĂĄndez de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
- Forbes Andrew
- Forbes Loretta
- Forton Daniel
- Fortune Louise
- Fottrell-Gould Deirdre
- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
- Friedrich Hinrichs Carl
- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
- Garcia Rebecca
- Gardiner-Hill Caroline
- Garrard Hywel
- Garrard William
- Gates Simon
- Gattas David
- Gellamucho Minerva
- Gendall Emma
- Genetu Roman Mary
- Geng Wenli
- Geri Guillaume
- Ghamraoui Ali
- Ghosh Alison
- Gibson Charly
- Girard Timothy
- Girijadevi Dinu
- Gledhill Lisa
- Godement Mathieu
- Golden David
- Goligher Ewan
- Gomm Linda
- Goodson Jennifer
- Goodwin Jayne
- Goossens Herman
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
- Hall Andrew
- Hall Kathryn
- Hamilton David Oliver
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Haniffa Rashan
- Haniffa Rashan
- Hanson Jane
- Harford Rachel
- Harland Cain
- Harrington Kate
- Harris Nichola
- Harrison Susie
- Hart Ciaran
- Harvala-Simmonds Heli
- Harvey Daniel
- Harward Meg
- Hawcutt Daniel
- Hawkins Nancy
- Hay Sophie Kennedy
- Hayes Kati
- Hayes Leanne
- Hays Carole
- Health Monash
- Heinonen Jonna
- Heming Nicholas
- Henderson Seton
- Henderson Steven
- Henning Jeremy
- Henry Joanne
- Heritier Stephane
- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
- Hird Clare
- Hodgson Carol
- Hoff Uwe
- Hoiting Oscar
- Holland Nicky
- Hollos Laszlo
- Homes Jennifer
- Hope David
- Hopkins Phil
- Hormis Anil
- Horton Michelle
- Horton Sarah
- Horvat Christopher
- Horvat Christopher
- Howcroft Clare
- Howle Ryan
- Huang David
- Huckle Abby
- Hughes Emma
- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
- Hutter Joanne
- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
- Jacques Nicola
- Jacquier Sophie
- Jagannathan Vijay
- Janin Pierre
- Jarczak Dominik
- Jeblaoui Asma
- Jeffrey Helen
- Jenkins Sarah
- Jha Rajeev
- Jhanji Shaman
- Johns Maggie
- Johnson David
- Johnson Rebekah
- Johnston Paul
- Jones Andrea
- Jones Jo
- Joseph Sibet
- José Nuno
- Juhaz Vera
- Kalchthaler Kyle
- Kalogirou Michael
- Kamel Toufik
- Karachi Tim
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kayani Abdul
- Kazemi Alex
- Keen Alexandra
- Keenan Samantha
- Keet Owen
- Kell Kay
- Kelly Martin
- Kelsall Olivia
- Kernan Maeve
- Kersiake Ian
- Khalid Imrana
- Khare Divya
- Kiiski Heikki
- Kimpton Sarah
- King Andrew
- Kinney Fiona
- Kirkby Amy
- Klinikum Neukölln Vivantes
- Kluge Stefan
- Knott Cameron
- Kol Mark
- Kolanos Steffi
- Koppen Cassandra
- Kosa Alma Gabriela
- Kotarski Viktor
- KovĂĄcs SĂĄndor
- KreĂ Gabriele
- Krishnamurthy Vinodh
- Kruger Peter
- Kruger Peter
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kunz Kevin
- Kurenda Catherine
- KutleĆĄa Marko
- KuĆĄan Ira
- KyereDiabour Thyra
- Kyeremeh Lynsey
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
- Lai Vivian
- Lamb Thomas
- Lamonagne Francois
- Lamontagne Francois
- Lamontagne Francois
- Lamontagne François
- Landais Mickaël
- Lane Janis-Best
- Lankester Liana
- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco CĂ©cile
- Lesona Eden
- Leszkoven JĂĄnos
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
- LeĂłn LĂłpez Rafael
- Limb James
- Linstrum Kelsey
- Linstrum Kelsey
- Litton Ed
- Litton Edward
- Litton Edward
- Lomme Kaatje
- London Emily
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- Lother Sylvain
- Lowe Benjamin
- Lowrey Julie
- Luis David
- Luk Tracy
- LâHotellier Sylvie
- Mackay Callum
- Mackay Euan
- MacLennan Sheila
- Maguire Teena
- Magyar IstvĂĄn
- Maiden Matthew
- Makowski Arystarch
- Malakoutis Salim
- Malfroy Sylvain
- Malissin Isabelle
- Maloney Carolyn
- Manax Victoria
- Mandadapu Vineela
- Mangindaan Yara
- Maquigneau Natacham
- Marabi Yaseen
- Mariappa Vasanth
- Marin-Corral Judith
- Markgraf Rene
- Marroquin Oscar
- Marshall John
- Marshall John
- Marshall Nicola
- Mart Emma
- Marten Nicole
- Martin Jane
- Martin Timothy
- Martynoga Robert
- Maselli Astrid
- Masse Marie-Helene
- Mateo LĂłpez Maria Isabel
- Matsa Ramprasad
- Mattocks Lehentha
- Maxime Virginie
- Mc Goldrick Clare
- Mc Master Moyra
- McArthur Colin
- McArthur Colin
- McAuley Daniel
- McAuley Daniel
- McAuley Danny
- McCallum Peter
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- McCullagh Iain
- McCullough James
- McDyer John
- McGhee Christopher
- McGlothin Anna
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGuigan Peter
- McGuinness Shay
- McGuinness Shay
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- McLachlan Danielle
- McMillan Alexandra
- McNamara Robert
- McNicholas Bairbre
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- McVerry Bryan
- McWilliam Stephen
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- Menzies Daniel
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- Mercier Romain
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- Metherell Stella
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- Mguni Nhlanhla
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- Millen Tina
- Miller Eliza
- Mills Gary
- Miln Rebecca
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- MirkoviÄ Gordan
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- Monchi Mehran
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- Montague Laura
- Montgomery Stephanie
- Montgomery Stephanie
- Moore Lorraine
- Morel Guillaume
- Moreno Cuesta Jeronimo
- Morgan Matt
- Morpeth Susan
- Morris Sheila
- Morrison Lynette
- Mouncey Paul
- Mouncey Paul
- Moviat M
- Mullan Dee
- Muller Grégoire
- Munt Sheila
- Murphy Sheenagh
- Murray Lauren
- Murthy Srinivas
- Murthy Srinivas
- Music Edvin
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- Nichol Alistair
- Nicholier Tiphaine Barbarin
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- Nicholson Sarah
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- Nortje Jurgens
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- Oborska Aneta
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- Orath Prabakaran Rajalakshmi
- Orford Neil
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- Orr Katrina
- Oza Deepali
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- OâDywer Michael
- OâKane Cecilia
- OâKane SinĂ©ad
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- OâNeill Aisling
- Page Valerie
- Paling A
- Panwar Rakshit
- Paramasivam Elankumaran
- Parekh Dhruv
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- Parke Rachael
- Parker Jane
- Parker Lorraine
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- Pellicano Annamaria
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- Pereira Rita
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- Phillips Barbara
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- Pletz Mathias
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- Pogreban Tatiana
- Pogson David
- Polderman F
- Polgarova Petra
- Pomeroy Fiona
- Porteous Rebecca
- Porter David
- Potter Alison
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- Powell Matthew
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- Pridee Nicole
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- Pulletz Mark
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- Quinn Kevin
- Qureshi Hafiz
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- Ramali Mohamed
- Ramanan Mahesh
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- Rauniyar Rashmi
- Raymakers Kik
- Reddy Amie
- Reddy Harsha
- Rees Tabitha
- Reeve Brenda
- Regli Adrian
- Reill Lorenz
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- Reschreiter Henrik
- Reynolds Claire
- Reynolds John
- Rhodes Jonathan
- Richards-Belle Alvin
- Ricketts Daniel
- Rietveld Ilse
- RistimÀki Sanna
- Ritzema Carter Jay
- Robert Alain
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- Robertson Yvonne
- Robinson Matt
- Robinson Philip
- Rochwerg Bram
- Rodden Natalie
- Rodriguez Fernandez Jorge
- Roedl Kevin
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- Rooney Kevin
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- Rostron Anthony
- Rowan Kathryn
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- Rowan Kathy
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- Rozendaal Wim
- Russell Robert
- Ryalls Kim
- Ryan Lucy
- Sagnier Anne
- Salazar Degracia Anna
- Salerno Tania
- Salet A
- Salisbury Sarah
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- Salmon Charlotte
- Sandhu Gyan
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- Sanil Ashish
- Santamaria John
- Santos Filipa
- Santos Marlene
- Santos Marlene
- Saull Michelle
- Saunders Christina
- Saunders Christina
- Schischka Livia
- Schneider Francis
- Schotsman Joost
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- SchĂŒtze Bianka
- Scully Michael
- Sellers Katharine
- Selvamoni Selvin
- Senya Ho Jan
- Seppelt Ian
- Serri Karim
- Sever Helena
- Seymour Christopher
- Seymour Christopher
- Shah Asim
- Shakih Arif
- Shankar-Hari Manu
- Shaw David
- Shaw Joanne
- Shearer Audrey
- Sheffield Jonathan
- Shehabi Yahya
- Shovelton Charmaine
- Shrestha Tapaswi
- Shyamsundar Murali
- Siami Shidasp
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Joanne
- Simpson Scott
- Singh Vanessa
- Singleton Jo
- Sinha Pratik
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- Small Charlotte
- Smallwood Andrew
- Smee Joanna
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- Smith John
- Smith Judith
- Smith Julie
- Smith Kirsy
- Smith Margaret
- Smith Roger
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- Spivey Michael
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- Stanworth Simon
- Sterba Martin
- Stevenson Hannah
- Stewart Richard
- Strzelecka Anna
- Sundara Raman Ajay
- Sundaran Dhinesh
- Sutherland Helen
- Sutterlin Laetitia
- Sutu Mihaela
- Sweet Katie
- Szakmany Tamas
- Szigligeti GĂĄbor
- SzĆke ViktĂłria
- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
- Thomas Amy
- Thomas Helen
- Thomas Matt
- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
- Touma Omar
- Trapani Tony
- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- vanât Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija BrajkoviÄ Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Äimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (nâ=â143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (nâ=â152), or no hydrocortisone (nâ=â108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (nâ=â137), shock-dependent (nâ=â146), and no (nâ=â101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
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- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Performance of single slope solar stills: A comparative study of conventional and modified stills with nanofluid and reflectors
- Author
- Publication venue
- EDP Sciences
- Publication date
- 01/01/2024
- Field of study
Nature has naturally desalinated water for centuries through the process of solar heating, where oceanic water transforms into vapor and then returns to Earth as freshwater precipitation. Freshwater is vital for sustaining life, but growing populations, industrial expansion, and increased agricultural production have created a rising demand for it. Desalination has emerged as a potential solution to address water scarcity. Existing desalination technologies fall into two categories: single-phase processes like reverse osmosis and electro-dialysis, and phase-change processes such as distillation and solar stills. While single phase processes provide freshwater, some rely on non-renewable fossil fuels for energy, indirectly contributing to greenhouse gas emissions. Solar distillation, in contrast uses renewable energy from the sun, offers a promising and sustainable alternative for freshwater production. Solar stills employ shallow water basins within enclosed structures, as moisture collects on the interior surface of the glass cover, cooled by natural airflow. In this study, two 250 X 250 mm2 single slope solar stills were designed, one conventional and the other modified with nanofluids and reflectors. The experiment assessed their performance in Hyderabadâs typical climate, with a glass cover slope of 17.45°. Both stills operated with a 1 cm water depth (500 ml) to observe the water distillate output. Readings were recorded for two different nanofluid concentrations (considering 0.08% and 0.1% of Cerium Oxide nanoparticles by volume mixed with water) allowing for a comparison of their cumulative hourly yields and effectiveness in increasing freshwater output
Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist
- Author
- Publication venue
- 'Hindawi Limited'
- Publication date
- 01/01/2017
- Field of study
Chronic hyponatremia is very rare in children and is often seen in the setting of congestive heart failure or liver failure in adults. Here, we report an 8-year-old child with hypothalamic glioma who presented with severe hyponatremia. Initial management consisted of fluid restriction. This was very difficult for the child to follow and the child developed bizarre drinking habits requiring intervention from child psychiatry. So therapy was initiated with low dose V2 receptor antagonist under close inpatient monitoring. While initial response was reassuring, her sodium levels tended to drift down with longer duration of treatment requiring us to increase the dose frequently. Her response to therapy and her stable clinical situation off therapy suggest that she may have reset osmostat
Targeted sequencing to confirm clinical diagnosis of Li-Fraumeni syndrome.
- Author
- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- Field of study
Novel method to differentiate 3T3 L1 cells in vitro to produce highly sensitive adipocytes for a GLUT4 mediated glucose uptake using fluorescent glucose analog
- Author
- A Balachandran
- AB Chapman
- AC Grant
- CS Rubin
- D Shao
- D-W Jung
- Divya Vishwanath
- DJ Klemm
- EC Shugart
- F-T Lin
- H Erding
- H Zaid
- HA Hostetler
- Harini Srinivasan
- HS Camp
- J Beloor
- J Lakshmanan
- JC Lawrence Jr
- JL Zacarias Ramirez
- Kakali Dhar
- L Speizer
- LF Barros
- M. N. Dixit
- Manjunath S. Patil
- NJ Morris
- P Cornelius
- PB Oatey
- PG Lloyd
- PH Ducluzeau
- R Somwar
- RA Coleman
- RA Coleman
- RM Cowherd
- RP Brun
- Sachin Kumar Agrawal
- Sowmya Seetarama
- V Zilberfarb
- W Yoo
- Y Li
- YD Tchoukalova
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diverse Metabolic Capacities of Fungi for Bioremediation
- Author
- A Akcil
- A Ceci
- A Khardenavis
- A Mishra
- A Mitra
- A Sinha
- A Testa
- A Ulcnik
- A VazAraLâijo
- AA Sari
- AD Watharkar
- AI Rodarte-Morales
- AK Verma
- AM Shine
- Anshuman A. Khardenavis
- AS Purnomo
- B Fan
- B Mouhamadou
- B Thippeswamy
- B Vacondio
- B Vishwanath
- C Desai
- C Janveja
- C Liers
- C Mougin
- C Thion
- CE RodrĂguez-RodrĂguez
- CM Rivera-Hoyos
- CS Karigar
- CW Theron
- D Damisa
- D Das
- D Isola
- D Kalyani
- D Marjadi
- D Mate
- E Aranda
- E FernĂĄndez-Fueyo
- E Kurniati
- E Marco
- E Marco-Urrea
- E Rosales
- E Strittmatter
- ERA Ferraz
- F Spina
- FI Hai
- FP Guengerich
- G Bayramoglu
- G Bleve
- G Qin
- GC Santos Bazanella dos
- GR Gao
- GR Jebapriya
- H Claus
- H Ichinose
- H NÔlvak
- H Thatoi
- Hemant J. Purohit
- I Pardo
- I Reya
- IMM Gillespie
- J Huang
- J Margot
- J Polak
- J Saxena
- J Sun
- J Turlo
- J Wu
- JP Kallio
- K Dhakar
- K Duarte
- K Habib
- K Ikehata
- K Kathiresan
- K Narayanan
- K Syed
- K-S Wong
- KK Sharma
- L Benghazi
- L Betancor
- L Connel
- L Ellegaard-Jensen
- L He
- L Ma
- L Naranjo-Briceno
- LM Divya
- M Asgher
- M Badia-Fabregat
- M Cobas
- M Hofrichter
- M Morel
- M Neifar
- M Vinichuk
- MAH Gazem
- MC Baratto
- MI Fonseca
- MP Singh
- MR Martins
- N Garg
- N Soobhany
- NR Sousa
- P Durairaj
- P Hickey
- P Singh
- P Torres-Salas
- P Xiao
- PJ Lien
- PS Nigam
- PW Baker
- Q Zhang
- R Caspi
- R Kataoka
- R Singh
- RA Rahman
- Radhika Deshmukh
- RC Bonugli-Santos
- RC Bonugli-Santos
- RM Bennett
- RW Kerrigan
- S Akhtar
- S Baker
- S Buvaneswari
- S Chakraborty
- S Damare
- S Kiran
- S Liu
- S LladĂł
- S Mumtaz
- S Ntougias
- S Sagarkar
- S Saroj
- S Silambarasan
- S Srivastava
- S Tegli
- S Wang
- S Xie
- S Yang
- S Yang
- SI Choe
- SKS Patel
- SQ Ni
- SS Bhattacharya
- SS Dhiman
- SS Dhiman
- T Fester
- T Hadibarata
- T Hadibarata
- T Hattori
- T Pita
- T Sakaki
- T Zhang
- TJ Cutright
- TM Martins
- TM Martins
- U Chhaya
- U Fillat
- V Balaji
- V Nayak
- VB Urlacher
- X Lin
- Y Li
- Y Yang
- Y Zhang
- YA Maruthi
- YT Chang
- YVS Santos dos
- ĂD GĂŒl
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/07/2016
- Field of study
Bioremediation refers to cost-effective and
environment-friendly method for converting the toxic,
recalcitrant pollutants into environmentally benign products
through the action of various biological treatments.
Fungi play a major role in bioremediation owing to their
robust morphology and diverse metabolic capacity. The
review focuses on different fungal groups from a variety of
habitats with their role in bioremediation of different toxic
and recalcitrant compounds; persistent organic pollutants,
textile dyes, effluents from textile, bleached kraft pulp,
leather tanning industries, petroleum, polyaromatic hydrocarbons,
pharmaceuticals and personal care products, and
pesticides. Bioremediation of toxic organics by fungi is the
most sustainable and green route for cleanup of contaminated
sites and we discuss the multiple modes employed by
fungi for detoxification of different toxic and recalcitrant
compounds including prominent fungal enzymes viz.,
catalases, laccases, peroxidases and cyrochrome P450
monooxygeneses. We have also discussed the recent
advances in enzyme engineering and genomics and
research being carried out to trace the less understood
bioremediation pathways
Diverse Metabolic Capacities of Fungi for Bioremediation
- Author
- A Akcil
- A Ceci
- A Khardenavis
- A Mishra
- A Mitra
- A Sinha
- A Testa
- A Ulcnik
- A VazAraLâijo
- AA Sari
- AD Watharkar
- AI Rodarte-Morales
- AK Verma
- AM Shine
- Anshuman A. Khardenavis
- AS Purnomo
- B Fan
- B Mouhamadou
- B Thippeswamy
- B Vacondio
- B Vishwanath
- C Desai
- C Janveja
- C Liers
- C Mougin
- C Thion
- CE RodrĂguez-RodrĂguez
- CM Rivera-Hoyos
- CS Karigar
- CW Theron
- D Damisa
- D Das
- D Isola
- D Kalyani
- D Marjadi
- D Mate
- E Aranda
- E FernĂĄndez-Fueyo
- E Kurniati
- E Marco
- E Marco-Urrea
- E Rosales
- E Strittmatter
- ERA Ferraz
- F Spina
- FI Hai
- FP Guengerich
- G Bayramoglu
- G Bleve
- G Qin
- GC Santos Bazanella dos
- GR Gao
- GR Jebapriya
- H Claus
- H Ichinose
- H NÔlvak
- H Thatoi
- Hemant J. Purohit
- I Pardo
- I Reya
- IMM Gillespie
- J Huang
- J Margot
- J Polak
- J Saxena
- J Sun
- J Turlo
- J Wu
- JP Kallio
- K Dhakar
- K Duarte
- K Habib
- K Ikehata
- K Kathiresan
- K Narayanan
- K Syed
- K-S Wong
- KK Sharma
- L Benghazi
- L Betancor
- L Connel
- L Ellegaard-Jensen
- L He
- L Ma
- L Naranjo-Briceno
- LM Divya
- M Asgher
- M Badia-Fabregat
- M Cobas
- M Hofrichter
- M Morel
- M Neifar
- M Vinichuk
- MAH Gazem
- MC Baratto
- MI Fonseca
- MP Singh
- MR Martins
- N Garg
- N Soobhany
- NR Sousa
- P Durairaj
- P Hickey
- P Singh
- P Torres-Salas
- P Xiao
- PJ Lien
- PS Nigam
- PW Baker
- Q Zhang
- R Caspi
- R Kataoka
- R Singh
- RA Rahman
- Radhika Deshmukh
- RC Bonugli-Santos
- RC Bonugli-Santos
- RM Bennett
- RW Kerrigan
- S Akhtar
- S Baker
- S Buvaneswari
- S Chakraborty
- S Damare
- S Kiran
- S Liu
- S LladĂł
- S Mumtaz
- S Ntougias
- S Sagarkar
- S Saroj
- S Silambarasan
- S Srivastava
- S Tegli
- S Wang
- S Xie
- S Yang
- S Yang
- SI Choe
- SKS Patel
- SQ Ni
- SS Bhattacharya
- SS Dhiman
- SS Dhiman
- T Fester
- T Hadibarata
- T Hadibarata
- T Hattori
- T Pita
- T Sakaki
- T Zhang
- TJ Cutright
- TM Martins
- TM Martins
- U Chhaya
- U Fillat
- V Balaji
- V Nayak
- VB Urlacher
- X Lin
- Y Li
- Y Yang
- Y Zhang
- YA Maruthi
- YT Chang
- YVS Santos dos
- ĂD GĂŒl
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of Antiplatelet Therapy on Survival and Organ SupportâFree Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel JakĆĄa
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastola Sirjana
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bean Sarah
- Beane Abi
- Beard Gregory
- Beasley Richard
- Beavis Sarah
- Bedford Caroline
- Beer Deborah
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Beltran Mercedes
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Benyon Sarah
- Benzekri Dalila
- Berdaguer Fernando
- Bergin Colin
- Berry Lindsay
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bhattarai Binita
- Bhimani Zahra
- Bhonagiri Deepak
- Biddie Simon
- Bihari Shailesh
- Binnie Alexandra
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Bland Yvonne
- Blank Elisabeth
- Bloos Frank
- Board Jasmin
- Bocher Simon
- Bociek Aneta
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bone Allison
- Bonner Stephen
- Bonten Marc
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- BrajkoviÄ Ana
- Brakké Karen
- Brant Emily
- Breen Patrick
- Bremmer Pamela
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brieger Klaus-Gerd
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Louise
- Browne Troy
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank
- Brunskill Nigel
- Bryan-Morris Kayla
- Buchanan Philip
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler Magdalena
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- BĂ©lteczki JĂĄnos
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callender Owen
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Lewis
- Campbell Ryan
- Campisi Josie
- Campos Sara
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Frédérick
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Brittney
- Carter David
- Carter Jay
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Cecconi Maurizio
- Centofanti John
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Marianne
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Connolly Karen
- Constantini Elena
- Contou Damien
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Cornell Sarah
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Cruz Raulle
- Cruz Rhoze
- Cudlipp Joanna
- Cuesta Jeronimo
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- Cviljevic Sabina
- CĂĄrcel Sheila
- da Rocha Joana
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darshana Sri
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawda Ashlish
- Day Christopher
- de Bus Liesbet
- de Courcy-Golder Kim
- de Jong Menno
- de Jonge Evert
- de Keulenaer Adrian
- de la Fuente Carmen
- de Man Angelique
- de Neef Mark
- de Waele Jan
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declerq Pierre
- Degracia Anna
- del Prado Michael
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Demetriou Carrie
- Dempster Debra
- Denmade Craig
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie
- Deshpande Kush
- Detry Michelle
- Deye Nicolas
- Dice Julie
- Digby Stephen
- Distler Michael
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Dolman Rozzie
- Donadee Chenell
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dragija Lidija
- Drapola Debra
- Drayss Maria
- Driscoll Alana
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Dujardin Romein
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Eastgate Christine
- Ebenezer R
- Edwards Alexandra
- Effelaar Evelien
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eichinger Fred
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
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- Turki Salah
- Turner Anne
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- Tv Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Umrani Zulfiqar
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van Bree Sjoerd
- van de Veerdonk Frank
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- van der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Oosten Nienke
- van Opdorp Marjolein
- van Vonderen Marit
- van Zanten Arthur
- van Zuylen Tamara
- Vanjak Christian
- Vanmali Piyush
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Venkatesh Bala
- Venz Ellen
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Vincent Rachel
- Virdee Satwinder
- Visser Yorik
- Vita Tina
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Voza Antonio
- Vrolijk Loes
- Vuylsteke Alain
- Wagh Atul
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watts Angela
- Waugh Victoria
- Webb Steve
- Weber Lisa
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Karen
- Williams Patricia
- Williams Tony
- Williams Virginie
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wiseman Sophie
- Wisniewski Mary
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Helen
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Äimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc