Automating design intent capture for component based software reusability

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1998.Includes bibliographical references (leaves 119-122).by Siva Kumar Dirisala.M.S

難治性固形がんに対する遺伝子発現促進に基づく全身投与型遺伝子内包高分子ミセルの構造最適化

学位の種別:課程博士University of Tokyo(東京大学

Sharing of Encrypted files in Blockchain Made Simpler

Recently, blockchain technology has attracted much attention of the research community in several domains requiring transparency of data accountability, due to the removal of intermediate trust assumptions from third parties. One such application is enabling file sharing in blockchain enabled distributed cloud storage. Proxy re-encryption is a cryptographic primitive that allows such file sharing by re-encrypting ciphertexts towards legitimate users via semi-trusted proxies, without them learning any information about the underlying message. To facilitate secure data sharing in the distributed cloud, it is essential to construct efficient proxy re-encryption protocols. In this paper, we introduce the notion of proxy self re-encryption (SE-PRE) that is highly efficient, as compared to the existing PRE schemes in the literature. We show that our self encryption scheme is provably CCA secure based on the DLP assumption and our proxy re-encryption scheme with self encryption is CCA secure under the hardness of the Computational Diffie Hellman (CDH) and Discrete Logarithm (DLP) assumption. Our novel encryption scheme, called self encryption, has no exponentiation or costly pairing operation. Even the re-encryption in SE-PRE does not have such operations and this facilitates the service provider with efficiency gain

Using Neutrosophic Trait Measures to Analyze Impostor Syndrome in College Students after COVID-19 Pandemic with Machine Learning

Impostor syndrome or Impostor phenomenon is a belief that a person thinks their success is due to luck or external factors, not their abilities. This psychological trait is present in certain groups like women. In this paper, we propose a neutrosophic trait measure to represent the psychological concept of the trait-anti trait using refined neutrosophic sets. This study analysed a group of 200 undergraduate students for impostor syndrome, perfectionism, introversion and self-esteem: after the COVID pandemic break in 2021. Data labelling was carried out using these neutrosophic trait measures. Machine learning models like Support Vector Machine(SVM), K-nearest neighbour (K-NN), and random forest were used to model the data; SVM provided the best accuracy of 92.15%

An Update on Clinical Burden, Diagnostic Tools, and Therapeutic Options of

Staphylococcus aureus is an important pathogen responsible for a variety of diseases ranging from mild skin and soft tissue infections, food poisoning to highly serious diseases such as osteomyelitis, endocarditis, and toxic shock syndrome. Proper diagnosis of pathogen and virulence factors is important for providing timely intervention in the therapy. Owing to the invasive nature of infections and the limited treatment options due to rampant spread of antibiotic-resistant strains, the trend for development of vaccines and antibody therapy is increasing at rapid rate than development of new antibiotics. In this article, we have discussed elaborately about the host-pathogen interactions, clinical burden due to S aureus infections, status of diagnostic tools, and treatment options in terms of prophylaxis and therapy

Molecular Cloning, Expression, and In Silico Structural Analysis of Guinea Pig IL-17

Interleukin-17A (IL-17A) is a potent proinflammatory cytokine and the signature cytokine of Th17 cells, a subset which is involved in cytokine and chemokine production, neutrophil recruitment, promotion of T cell priming, and antibody production. IL-17 may play an important role in tuberculosis and other infectious diseases. In preparation for investigating its role in the highly relevant guinea pig model of pulmonary tuberculosis, we cloned guinea pig IL-17A for the first time. The complete coding sequence of the guinea pig IL-17A gene (477 nucleotides; 159 amino acids) was subcloned into a prokaryotic expression vector (pET-30a) resulting in the expression of a 17 kDa recombinant guinea pig IL-17A protein which was confirmed by mass spectrometry analysis. Homology modeling of guinea pig IL-17A revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted for this protein showed the presence of one extra helix in the N-terminal region. The expression profile of IL-17A was analyzed quantitatively in spleen, lymph node, and lung cells from BCG-vaccinated guinea pigs by real-time PCR. The guinea pig IL-17A cDNA and its recombinant protein will serve as valuable tools for molecular and immunological studies in the guinea pig model of pulmonary TB and other human diseases