Magnetic coupling of a rotating black hole with its surrounding accretion disk

Effects of magnetic coupling (MC) of a rotating black hole (BH) with its surrounding accretion disk are discussed in detail in the following aspects: (i) The mapping relation between the angular coordinate on the BH horizon and the radial coordinate on the disk is modified based on a more reasonable configuration of magnetic field, and a condition for coexistence of the Blandford-Znajek (BZ) and the MC process is derived. (ii) The transfer direction of energy and angular momentum in MC process is described equivalently by the co-rotation radius and by the flow of electromagnetic angular momentum and redshifted energy, where the latter is based on an assumption that the theory of BH magnetosphere is applicable to both the BZ and MC processes. (iii) The profile of the current on the BH horizon and that of the current density flowing from the magnetosphere onto the horizon are given in terms of the angular coordinate of the horizon. It is shown that the current on the BH horizon varies with the latitude of the horizon and is not continuous at the angular boundary between the open and closed magnetic field lines. (iv) The MC effects on disk radiation are discussed, and a very steep emissivity is produced by MC process, which is consistent with the recent XMM-Newton observation of the nearby bright Seyfert 1 galaxy MCG-6-30-15 by a variety of parameters of the BH-disk system.Comment: 24 pages, 19 figures. Accepted by Ap

Screw instability of the magnetic field connecting a rotating black hole with its surrounding disk

Screw instability of the magnetic field connecting a rotating black hole (BH) with its surrounding disk is discussed based on the model of the coexistence of the Blandford-Znajek (BZ) process and the magnetic coupling (MC) process (CEBZMC). A criterion for the screw instability with the state of CEBZMC is derived based on the calculations of the poloidal and toroidal components of the magnetic field on the disk. It is shown by the criterion that the screw instability will occur, if the BH spin and the power-law index for the variation of the magnetic field on the disk are greater than some critical values. It turns out that the instability occurs outside some critical radii on the disk. It is argued that the state of CEBZMC always accompanies the screw instability. In addtition, we show that the screw instability contributes only a small fraction of magnetic extraction of energy from a rotating BH.Comment: 18 pages, 13 figures; Accepted by Ap

Effect of Tumor Necrosis Factor-α on Neutralization of Ventricular Fibrillation in Rats with Acute Myocardial Infarction

The purpose of this study was to explore the effects of tumor necrosis factor-α (TNF-α) on ventricular fibrillation (VF) in rats with acute myocardial infarction (AMI). Rats were randomly classified into AMI group, sham operation group and recombinant human tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) group. Spontaneous and induced VFs were recorded. Monophasic action potentials (MAPs) among different zones of myocardium were recorded at eight time points before and after ligation and MAP duration dispersions (MAPDds) were calculated. Then expression of TNF-α among different myocardial zones was detected. After ligation of the left anterior descending coronary artery, total TNF-α expression in AMI group began to markedly increase at 10 min, reached a climax at 20–30min, and then gradually decreased. The time-windows of VFs and MAPDds in the border zone performed in a similar way. At the same time-point, the expression of TNF-α in the ischemia zone was greater than that in the border zone, and little in the non-ischemia zone. Although the time windows of TNF-α expression, the MAPDds in the border zone and the occurrence of VFs in the rhTNFR:Fc group were similar to those in the AMI group, they all decreased in the rhTNFR:Fc group. Our findings demonstrate that TNF-α could enlarge the MAPDds in the border zone, and promote the onset of VFs

A novel “off-on” fluorescent probe for the detection of nickel ions and its clinical application

Nickel serves as an essential micronutrient for the human body, playing a vital role in various enzymatic processes. However, excessive nickel entering the environment can cause pollution and pose serious risks to animals, plants, and human health. High concentrations of nickel ions in the human body increase the risk of various diseases, highlighting the need for accurate measurement of nickel ions levels. In this study, we designed a sequence-specific cleavage probe for nickel (II) ion called SSC-Ni. Similar to the TaqMan probe, SSC-Ni is an off-on fluorescent probe with an exceptionally low background fluorescence signal. It exhibits high detection specificity, making it highly selective for nickel ions, and the detection limit of the probe towards Ni2+ is as low as 82 nM. The SSC-Ni probe can be utilized for convenient and cost-effective high-throughput quantitative detection of nickel ions in serum. Its user-friendly operation and affordability make it a practical solution. By addressing the lack of simple and effective nickel ion detection methods, this probe has the potential to contribute significantly to environmental monitoring and the protection of human health