Genetic Variation At 8Q24, Family History Of Cancer, And Upper Gastrointestinal Cancers In A Chinese Population

Genetic variation at 8q24 is associated with prostate, bladder, breast, colorectal, thyroid, lung, ovarian, UADT, liver and stomach cancers. However, a role for variation at 8q24 in familial clustering of upper gastrointestinal cancers has not been studied. In order to explore potential inherited susceptibility, we analyzed epidemiologic data from a population-based case-control study of upper gastrointestinal cancers from Taixing, China. The study population includes 204 liver, 206 stomach, and 218 esophageal cancer cases and 415 controls. Associations between 8q24 rs1447295, rs16901979, rs6983267 and these cancers were stratified by family history of cancer. Odds ratios and 95% confidence intervals were adjusted for potential confounders: age, sex, education, tobacco smoking, alcohol consumption, and BMI at interview. We also adjusted for hepatitis B and aflatoxin (liver cancer) and Helicobacter pylori (stomach cancer). In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (ORadj 2.80; 95% CI 1.15–6.80). Heterogeneity was observed (Pheterogeneity=0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer. When considered in a genetic risk score model, each additional 8q24 risk genotype increased the odds of liver cancer by two-fold among those with a family history of cancer (ORadj 2.00; 95% CI 1.15–3.47). These findings suggest that inherited susceptibility to liver cancer may exist in the Taixing population and that variation at 8q24 might be a genetic component of that inherited susceptibility

Roadmap on measurement technologies for next generation structural health monitoring systems

Structural health monitoring (SHM) is the automation of the condition assessment process of an engineered system. When applied to geometrically large components or structures, such as those found in civil and aerospace infrastructure and systems, a critical challenge is in designing the sensing solution that could yield actionable information. This is a difficult task to conduct cost-effectively, because of the large surfaces under consideration and the localized nature of typical defects and damages. There have been significant research efforts in empowering conventional measurement technologies for applications to SHM in order to improve performance of the condition assessment process. Yet, the field implementation of these SHM solutions is still in its infancy, attributable to various economic and technical challenges. The objective of this Roadmap publication is to discuss modern measurement technologies that were developed for SHM purposes, along with their associated challenges and opportunities, and to provide a path to research and development efforts that could yield impactful field applications. The Roadmap is organized into four sections: distributed embedded sensing systems, distributed surface sensing systems, multifunctional materials, and remote sensing. Recognizing that many measurement technologies may overlap between sections, we define distributed sensing solutions as those that involve or imply the utilization of numbers of sensors geometrically organized within (embedded) or over (surface) the monitored component or system. Multi-functional materials are sensing solutions that combine multiple capabilities, for example those also serving structural functions. Remote sensing are solutions that are contactless, for example cell phones, drones, and satellites. It also includes the notion of remotely controlled robots

An Improved FAST Algorithm Based on Image Edges for Complex Environment

In complex environments such as those with low textures or obvious brightness changes, point features extracted from a traditional FAST algorithm cannot perform well in pose estimation. Simultaneously, the number of point features extracted from FAST is too large, which increases the complexity of the build map. To solve these problems, we propose an L-FAST algorithm based on FAST, in order to reduce the number of extracted points and increase their quality. L-FAST pays more attention to the intersection of line elements in the image, which can be extracted directly from the related edge image. Hence, we improved the Canny edge extraction algorithm, including denoising, gradient calculation and adaptive threshold. These improvements aimed to enhance the sharpness of image edges and effectively extract the edges of strong light or dark areas in the images as brightness changed. Experiments on digital standard images showed that our improved Canny algorithm was smoother and more continuous for the edges extracted from images with brightness changes. Experiments on KITTI datasets showed that L-FAST extracted fewer point features and increased the robustness of SLAM

TOA-Based Source Localization: A Linearization Approach Adopting Coordinate System Translation

This paper addresses the localization of a timing signal source based on the time of arrival (TOA) measurements that are collected from nearby sensors that are position known and synchronized to each other. Generally speaking, for such TOA-based source localization, the corresponding observation equations contain nonlinear relationship between measurements and unknown parameters, which normally results in the nonexistence of any efficient unbiased estimator that attains the Cramer-Rao lower bound (CRLB). In this paper, we devise a new approach that utilizes linearization and adopts suitable coordinate system translation to eliminate nonlinearity from the converted observation equations. The performance analysis and simulation study conducted show that our proposed algorithm can achieve the CRLB when the zero-mean Gaussian and independent measurement errors are sufficiently small

Multiphase transport phenomena in composite phase change materials for thermal energy storage

Thermal energy is at the heart of the whole energy chain providing a main linkage between the primary and secondary energy sources. Thermal energy storage (TES) has a pivotal role to play in the energy chain and hence in future clean energy systems. However, a competitive TES technology requires a number of scientific and technological challenges to be addressed including materials, components and devices, and integration of the devices within energy networks and associated dynamic optimization. This requires fundamental understanding of the underlying physics particularly flow and heat transfer of a multiphase system across a very large spatial length scale from atomic/molecular scale to system scale. This talk will first briefly outline the background and challenges of energy storage. Discussion will then be on TES covering TES materials, TES devices (TES heat exchangers) and system integration, with a specific focus on flow and heat transfer across large lengthscales. TES can be sensible heat, latent heat or thermochemical based. This talk shall use the latent heat storage materials, often called phase change materials (PCM), as an example, particularly inorganic salts based PCMs for medium and high temperature applications. Two key challenges for such materials are chemical incompatibility and low thermal conductivity. The use of composite materials provides an avenue to meeting the challenges. Such composite materials use a structural supporting material and a thermal conductivity enhancement material. A right combination of the salt, the structural supporting material and the thermal conductivity enhancement material could give a hierarchical structure that is able to encapsulate the molten salt and give a substantial enhancement in the thermal conductivity. Our recent progress in these aspects will also be covered in the talk.Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .International centre for heat and mass transfer.American society of thermal and fluids engineers

Transcriptome Analysis Reveals the Genes Related to Pollen Abortion in a Cytoplasmic Male-Sterile Soybean (Glycine max (L.) Merr.)

Cytoplasmic male sterility (CMS) lays a foundation for the utilization of heterosis in soybean. The soybean CMS line SXCMS5A is an excellent CMS line exhibiting 100% male sterility. Cytological analysis revealed that in SXCMS5A compared to its maintainer SXCMS5B, its tapetum was vacuolated and abnormally developed. To identify the genes and metabolic pathways involving in pollen abortion of SXCMS5A, a comparative transcriptome analysis was conducted between SXCMS5A and SXCMS5B using flower buds. A total of 372,973,796 high quality clean reads were obtained from 6 samples (3 replicates for each material), and 840 differentially expressed genes (DEGs) were identified, including 658 downregulated and 182 upregulated ones in SXCMS5A compared to SXCMS5B. Among them, 13 DEGs, i.e., 12 open reading frames (ORFs) and 1 COX2, were mitochondrial genome genes in which ORF178 and ORF103c were upregulated in CMS lines and had transmembrane domain(s), therefore, identified as CMS candidate mitochondrial genes of SXCMS5A. Furthermore, numerous DEGs were associated with pollen wall development, carbohydrate metabolism, sugar transport, reactive oxygen species (ROS) metabolism and transcription factor. Some of them were further confirmed by quantitative real time PCR analysis between CMS lines with the same cytoplasmic source as SXCMS5A and their respective maintainer lines. The amount of soluble sugar and adenosine triphosphate and the activity of catalase and ascorbic acid oxidase showed that energy supply and ROS scavenging decreased in SXCMS5A compared to SXCMS5B. These findings provide valuable information for further understanding the molecular mechanism regulating the pollen abortion of soybean CMS

Nano TiO2-engineered anti-corrosion concrete for sewage system

YesIn this study, anti-corrosion concrete for sewage system was developed with nano TiO2 (NT) and reactive powder concrete (RPC). The corrosion resistances of NT modified RPC (NTMRPC) in high concentration enhanced sewage were investigated from the perspectives of biological, physical and chemical corrosion resistances, respectively. In addition, mechanical properties of NTMRPC after sewage corrosion were also studied. Research results indicated that NT can endow RPC with antimicrobial property through their microorganism biodegradation properties. The inhibition and elimination rates of NTMRPC to its surface microorganisms were 37.35% and 80.93%, respectively. After sewage corrosion, the surface roughness, mass loss and deterioration depth of RPC were decreased by 62.57%, 15.48% and 18.44% due to the NT inclusion, respectively. In addition, the pH values of RPC in the deterioration depth ranges of 0-3 mm and 3-6 mm were increased by 11.45% and 23.62%, respectively. NT can restrain the strength deterioration of RPC in high concentration enhanced sewage. This may be due to the improved sewage biological anti-corrosion performances of RPC by inhibiting/eliminating the microorganisms on the surface of RPC as well as the enhanced sewage physical/chemical anti-corrosion performances of RPC by improving the compactness of RPC.The authors thank the funding provided by the National Science Foundation of China 513 (51978127 and 51908103), and National Key Research and Development Program of China 514 (2018YFC070560 and 2017YFC0703410).The full-text of this article will be released for public view at the end of the publisher embargo on 13th Jan 2023

Aminative Umpolung Synthesis of Aryl Vicinal Diamines from Aromatic Aldehydes

In this paper an aminative umpolung synthesis of aryl vicinal diamines from aldehydes and <i>N</i>-Ts imines is described. Electrophilic aromatic aldehydes were smoothly converted into delocalized 2-azaallylanions via condensation with 2,2-diphenylglycine in methanol and subsequent decarboxylation in THF and underwent further reaction with <i>N</i>-Ts imines to give a variety of 1,2-diamine derivatives in good yields with high <i>syn</i>/<i>anti</i> diastereoselectivity