Progressive Chronic Inflammatory Demyelinating Polyneuropathy in a Child with Central Nervous System Involvement and Myopathy

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic disorder, manifesting with monophasic or relapsing course. Progressive course is rare in children. The article presents a boy with progressive generalized muscle weakness and areflexia since the age of two, developed after viral infection. Electromyoneurography showed severe neurogenic lesion, with myopathic pattern in proximal muscles. Increased serum ganglioside antibody titers (anti-GM1 and anti-GD1b) were registered. Sural nerve biopsy revealed demyelination and onion bulbs. Inflammatory perivascular CD3 positive infiltrates were present in muscle and nerve biopsies. Brain magnetic resonance imaging showed cortical atrophy, hyperintensities of the white matter and gray matter hypointensities. Improvement occurred on intravenous immune globulins and methylprednisolone treatment. Demyelination might develop in central and peripheral nervous system associated with inflammatory myopathy in patients with progressive course of CIDP

Therapeutic implication of molecular profiling in patients with non – small cell lung cancer

Traditional, \u27one size fits all\u27 approach to chemotherapy has reached efficacy plateau. The development of molecular biomarkers is crucial for improving efficacy of therapy in patients with NSCLC.We review prognostic and predictive value of molecular biomarkers with special overview on biomarker-driven personalized therapy of NSCLC. Main focus is this review is on significance of EGFR mutations and ALK – EML4 alterations on due to availability of targeted drugs against these specific aberrations