Antiremodelling Efficacy and Clinical Safety of Zofenopril in Patients with Grade 1and 2 Hypertension

Objective: to estimate the antihypertensive, antiremodelling efficacy and clinical tolerability of the monotherapy with Zofenopril in patients with Grade 1 and 2 hypertension (HT 1 and 2) Materials and Methods: The study included 30 patients aged from 30 to 60 years with HT 1 and 2 (ESH/ESC, 2013) without severe comorbidities and cardiovascular complications. Zofenopril was prescribed as monotherapy to HT patients who had never been treated before or patients after one week of lavage from previous antihypertensive therapy, who did not reach target levels of BP. Before and during treatment all patients were checked on office BP using Korotkov’s method and ambulatory blood pressure monitoring (ABPM). Echocardiography and Doppler sonography were carried out by standard methods using the recommendations of the American Society of Echocardiography. Intima-media thickness (IMT) of the carotid artery and brachial artery was measured by a 7.5MHz high-resolution ultrasound. Assessment of flow-mediated dilation (FMD) of the brachial artery was used as a method of determining endothelial function. Results: A 12-week monotherapy with Zofenopril in average daily dose of 36.0±19.54 mg showed a high antihypertensive efficacy and a good safety profile without side effects. We noted a reliable decrease in systolic BP (SBP), diastolic BP (DBP), mean BP, and pulse pressure (PP) by -19.53±5.93%, -18.64±7.18%, BP -19.05±6.14%, and -20.65±12.07%, respectively. Target SBP, DBP, and SBP+DBP were reached in 90%, 86.6%, and 83.3% of patients, respectively. We found a significant regression of LVH, significant improvement in volume indicators of LV echogeometry and parameters of FMD of the brachial artery, as well as a decrease in IMT of carotid and brachial arteries. Monotherapy with Zofenopril showed metabolic neutrality regarding the lipid and carbohydrate metabolism, a good safety profile without the side effects and undesired events

Comparative Economic Evaluation of Haemophilus influenzae Type b Vaccination in Belarus and Uzbekistan

BACKGROUND: Hib vaccine has gradually been introduced into more and more countries during the past two decades, partly due to GAVI Alliance support to low-income countries. However, since Hib disease burden is difficult to establish in settings with limited diagnostic capacities and since the vaccine continues to be relatively expensive, some Governments remain doubtful about its value leading to concerns about financial sustainability. Similarly, several middle-income countries have not introduced the vaccine. The aim of this study is to estimate and compare the cost-effectiveness of Hib vaccination in a country relying on self-financing (Belarus) and a country eligible for GAVI Alliance support (Uzbekistan). METHODS AND FINDINGS: A decision analytic model was used to estimate morbidity and mortality from Hib meningitis, Hib pneumonia and other types of Hib disease with and without the vaccine. Treatment costs were attached to each disease event. Data on disease incidence, case fatality ratios and costs were primarily determined from national sources. For the Belarus 2009 birth cohort, Hib vaccine is estimated to prevent 467 invasive disease cases, 4 cases of meningitis sequelae, and 3 deaths, while in Uzbekistan 3,069 invasive cases, 34 sequelae cases and 341 deaths are prevented. Estimated costs per discounted DALY averted are US$9,323 in Belarus and US$ 267 in Uzbekistan. CONCLUSION: The primary reason why the cost-effectiveness values are more favourable in Uzbekistan than in Belarus is that relatively more deaths are averted in Uzbekistan due to higher baseline mortality burden. Two other explanations are that the vaccine price is lower in Uzbekistan and that Uzbekistan uses a three dose schedule compared to four doses in Belarus. However, when seen in the context of the relative ability to pay for public health, the vaccine can be considered cost-effective in both countries

The Importance of Studying the Life and Work of Uzbek Composers in Music Classes of General Education Schools

Melodies and songs of master composers can easily compete with the musical works of the world's peoples who have a professional high musical culture with their logical clarity and level of philosophical observation, complete and deep content. In the article, the author highlighted the importance of studying the life and work of Uzbek composers in music classes of general education schools

The Importance of Studying the Life and Work of Uzbek Composers in Music Classes of General Education Schools

Melodies and songs of master composers can easily compete with the musical works of the world's peoples who have a professional high musical culture with their logical clarity and level of philosophical observation, complete and deep content. In the article, the author highlighted the importance of studying the life and work of Uzbek composers in music classes of general education schools

Creation of Composers - Basis of Music Culture

The composer has performed various tasks in the past. First, he is a creator of new, original melodies and songs. Secondly, the composer created their rhythmic and melodic variants on the topic of ready-made tunes. In the article, the author elaborated on the topic of the basis of composers' creativity-musical culture, and explained the history, origin and prospects of composition

Creation of Composers - Basis of Music Culture

The composer has performed various tasks in the past. First, he is a creator of new, original melodies and songs. Secondly, the composer created their rhythmic and melodic variants on the topic of ready-made tunes. In the article, the author elaborated on the topic of the basis of composers' creativity-musical culture, and explained the history, origin and prospects of composition

Thermodynamic evaluation of methane oxycondensation reaction

In this article, factors affecting the rate of methane oxycondensation reaction, and kinetic laws of the reaction are studied in a flow differential reactor. Values of parallel and sequential reactions in the oxidative condensation of methane at different temperatures for methane conversion and product selectivity, equilibrium composition of oxidation condensation reaction components at different temperatures, based on the study of factors such as the rate of methane conversion into products at different temperatures, the reactions of the formation of ethane, ethylene, acetylene, carbon dioxide from methane were studied

Structure, aromatic properties and preparation of the quinazolin-4-one molecule

The government has emphasized the significance of making significant investments in scientific research to develop herbicides, fungicides, bactericides, anthelmintic agents, weed and pest control agents, and alternative pesticides that are eco-friendly and can be exported. In this research, the aromaticity of quinazolin-4-one a and p was studied. A one-stage method for obtaining quinazolin-4-one a was developed by condensation of anthranilic acid and formamide when heated to Wood's alloy. Quinazolin-4-one exhibits conformity with Hückel's rules upon undergoing a reaction with alkali metals, hydrides, and alkalis. An investigation was performed to assess the aromaticity of both para and ortho quinazolin-4-one. Quinazolin-4-one a was obtained through a one-step process, which involved condensing anthranilic acid and formamide using Wood's alloy at a temperature of 130-135 ºС for two hours, which was found to be optimal

PREPARATION AND STRUCTURE OF 6-BENZYLAMINOPURINE

6-Benzylaminopurine is a broad-spectrum plant growth regulator, capable of rejuvenating plants, removing plants from dormancy, causing the formation of side shoots and root shoots, stimulating the formation of chlorophyll and positively affecting photosynthesis, making the leaf darker and greener, stronger, in many crops, when outside root processing of green fruits and berries, is able to postpone the ripening period somewhat in favor of size and weight