750 research outputs found
Shoulder posture and median nerve sliding
Background: Patients with upper limb pain often have a slumped sitting position and poorshoulder posture. Pain could be due to poor posture causing mechanical changes (stretch; localpressure) that in turn affect the function of major limb nerves (e.g. median nerve). This studyexamines (1) whether the individual components of slumped sitting (forward head position, trunkflexion and shoulder protraction) cause median nerve stretch and (2) whether shoulderprotraction restricts normal nerve movements.Methods: Longitudinal nerve movement was measured using frame-by-frame cross-correlationanalysis from high frequency ultrasound images during individual components of slumped sitting.The effects of protraction on nerve movement through the shoulder region were investigated byexamining nerve movement in the arm in response to contralateral neck side flexion.Results: Neither moving the head forward or trunk flexion caused significant movement of themedian nerve. In contrast, 4.3 mm of movement, adding 0.7% strain, occurred in the forearm duringshoulder protraction. A delay in movement at the start of protraction and straightening of thenerve trunk provided evidence of unloading with the shoulder flexed and elbow extended and thescapulothoracic joint in neutral. There was a 60% reduction in nerve movement in the arm duringcontralateral neck side flexion when the shoulder was protracted compared to scapulothoracicneutral.Conclusion: Slumped sitting is unlikely to increase nerve strain sufficient to cause changes tonerve function. However, shoulder protraction may place the median nerve at risk of injury, sincenerve movement is reduced through the shoulder region when the shoulder is protracted andother joints are moved. Both altered nerve dynamics in response to moving other joints and localchanges to blood supply may adversely affect nerve function and increase the risk of developingupper quadrant pain
Leverage, Linkage, and Leakage: Problems with the Private Pension System and How They Should Inform the Social Security Reform Debate
The argument for Social Security privatization is, at bottom, simple: we need more, and better, advance funding of the public retirement system. In particular, we need to commit a portion of FICA tax to privately managed investment accounts, which will purchase investment instruments that promise higher rates of return than the government debt instruments in which the Social Security surplus is currently invested. The privatization debate has centered on the extent to which Social Security faces an impending demographic crisis during the coming decades, whether privatization is fundamentally inconsistent with the idea of social insurance, whether privatization financial projections are accurate, and whether privatization is a more rational means of securing and improving the financial status of retirees than the current Social Security system
Photonic qubits, qutrits and ququads accurately prepared and delivered on demand
Reliable encoding of information in quantum systems is crucial to all
approaches to quantum information processing or communication. This applies in
particular to photons used in linear optics quantum computing (LOQC), which is
scalable provided a deterministic single-photon emission and preparation is
available. Here, we show that narrowband photons deterministically emitted from
an atom-cavity system fulfill these requirements. Within their 500 ns coherence
time, we demonstrate a subdivision into d time bins of various amplitudes and
phases, which we use for encoding arbitrary qu-d-its. The latter is done
deterministically with a fidelity >95% for qubits, verified using a newly
developed time-resolved quantum-homodyne method.Comment: 5 pages, 4 figure
Highly Efficient Source for Indistinguishable Photons of Controlled Shape
We demonstrate a straightforward implementation of a push-button like
single-photon source which is based on a strongly coupled atom-cavity system.
The device operates intermittently for periods of up to 100 microseconds, with
single-photon repetition rates of 1.0 MHz and an efficiency of 60 %. Atoms are
loaded into the cavity using an atomic fountain, with the upper turning point
near the cavity's mode centre. This ensures long interaction times without any
disturbances induced by trapping potentials. The latter is the key to reaching
deterministic efficiencies as high as obtained in probabalistic
photon-heralding schemes. The price to pay is the random loading of atoms into
the cavity and the resulting intermittency. However, for all practical
purposes, this has a negligible impact
Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells
SummaryRemoval of TRF2, a telomere shelterin protein, recapitulates key aspects of telomere attrition including the DNA-damage response and cell-cycle arrest [1]. Distinct from the response of proliferating cells to loss of TRF2 [2, 3], in rodent noncycling cells, TRF2 inhibition promotes differentiation and growth [4, 5]. However, the mechanism that couples telomere gene-silencing features [6–8] to differentiation programs has yet to be elucidated. Here we describe an extratelomeric function of TRF2 in the regulation of neuronal genes mediated by the interaction of TRF2 with repressor element 1-silencing transcription factor (REST), a master repressor of gene networks devoted to neuronal functions [9–12]. TRF2-REST complexes are readily detected by coimmunoprecipitation assays and are localized to aggregated PML-nuclear bodies in undifferentiated pluripotent human NTera2 stem cells. Inhibition of TRF2, either by a dominant-negative mutant or by RNA interference, dissociates TRF2-REST complexes resulting in ubiquitin-proteasomal degradation of REST. Consequentially, REST-targeted neural genes (L1CAM, β3-tubulin, synaptophysin, and others) are derepressed, resulting in acquisition of neuronal phenotypes. Notably, selective damage to telomeres without affecting TRF2 levels causes neither REST degradation nor cell differentiation. Thus, in addition to protecting telomeres, TRF2 possesses a novel role in stabilization of REST thereby controlling neural tumor and stem cell fate
Optical Properties of MFe_4P_12 filled skutterudites
Infrared reflectance spectroscopy measurements were made on four members of
the MFe_4P_12 family of filled skutterudites, with M=La, Th, Ce and U. In
progressing from M=La to U the system undergoes a metal-insulator transition.
It is shown that, although the filling atom induces such dramatic changes in
the transport properties of the system, it has only a small effect on lattice
dynamics. We discuss this property of the compounds in the context of their
possible thermoelectric applications.Comment: Manuscript in ReVTeX format, 7 figures in PostScirpt forma
Unusual behaviors in the transport properties of REFeP (RE: La, Ce, Pr, and Nd)
We have investigated the resistivity (), thermoelectric power (TEP) and
Hall coefficient () on high quality single crystals of
REFeP. TEP in CeFeP is extremely large (
0.5mV/K at 290K) with a peak of 0.75mV/K at around 65K. The Hall
mobility also shows a peak at 65K, suggesting carriers with heavy masses
developed at lower temperatures related with the f-hybridized band. Both Pr-
and Nd- systems exhibit an apparent increase of with decreasing
temperature far above their magnetic transition temperatures. In the same
temperature ranges, TEP exhibits unusually large absolute values of -50V/K
for PrFeP and -15V/K for NdFeP, respectively.
For PrFeP, such anomalous transport properties suggest an unusual
ground state, possibly related with the Quadrupolar Kondo effect.Comment: 5 pages, 8 figure
Evidence for a common physical description of non-Fermi-liquid behavior in f-electron systems
The non-Fermi-liquid (NFL) behavior observed in the low temperature specific
heat and magnetic susceptibility of f-electron systems is
analyzed within the context of a recently developed theory based on Griffiths
singularities. Measurements of and in the systems
, , and (M = Pd,
Pt) are found to be consistent with predicted by this model with in the NFL regime.
These results suggest that the NFL properties observed in a wide variety of
f-electron systems can be described within the context of a common physical
picture.Comment: 4 pages, 4 figure
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