The Distribution of the Photoreceptor Outer Segment Length in a Healthy Population

Purpose. To evaluate the effects of age and sex on the photoreceptor outer segment (PROS) length in healthy eyes, using spectral-domain optical coherence tomography (SD-OCT). Methods. A total of 97 eyes of 97 healthy participants (spherical equivalent < ±1 diopters [D]) were scanned with SD-OCT. The patients were divided into 3 groups by age: group 1 (0–20 years), group 2 (21–40 years), and group 3 (41–60 years). The PROS length was defined as the distance from the inner surface of IS/OS (inner segment/outer segment) band to the inner surface of retinal pigment epithelium (RPE). Results. The mean PROS length was 52.01 ± 3.79 μm in females and 53.41 ± 3.37 μm in males (p=0.061). The mean PROS length of the different groups was 53.70 ± 3.18 μm (0–20 years), 52.14 ± 3.64 μm (21–40 years), and 52.20 ± 3.95 μm (41–60 years) (p=0.155; ANOVA test). Multiple linear regression analysis revealed a −0.039 μm decline in PROS length per year (p=0.074) and a −1.408 μm decline in females (p=0.055). Conclusion. The difference in PROS length was not statistically significant neither for age nor for gender; females tended to have a lower PROS length than males, and PROS length was slightly higher in the first two decades of life