Biola Hour Highlights, 1976 - 08

The Way Out of Depression: Psalm 3 by Al Sanders Panel Discussion with Richard Chase, Charles Feinberg, and Samuel Sutherland History Panel with Richard Chase, James O. Henry, Ethel Rankin, Dietrick Buss Daniel by Lloyd Andersonhttps://digitalcommons.biola.edu/bhhs/1030/thumbnail.jp

Biola Hour Highlights, 1976 - 03

Ephesians 1:15 by Al Sanders Stress by Charles Swindoll Revelation by Lloyd Anderson Panel Discussions with Richard Chase, Charles Feinberg, and Samuel Sutherlandhttps://digitalcommons.biola.edu/bhhs/1025/thumbnail.jp

Prognostic factors in prostate cancer

Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical prostatectomy. Gleason score, tumour volume, surgical margins and Ki-67 index have the most significant prognosticators. Also the origins from the transitional zone, p53 status in cancer tissue, stage, and aneuploidy have shown prognostic significance. Progression-associated features include Gleason score, stage, and capsular invasion, but PSA is also highly significant. Progression can also be predicted with biological markers (E-cadherin, microvessel density, and aneuploidy) with high level of significance. Other prognostic features of clinical or PSA-associated progression include age, IGF-1, p27, and Ki-67. In patients who were treated with radiotherapy the survival was potentially predictable with age, race and p53, but available research on other markers is limited. The most significant published survival-associated prognosticators of prostate cancer with extension outside prostate are microvessel density and total blood PSA. However, survival can potentially be predicted by other markers like androgen receptor, and Ki-67-positive cell fraction. In advanced prostate cancer nuclear morphometry and Gleason score are the most highly significant progression-associated prognosticators. In conclusion, Gleason score, capsular invasion, blood PSA, stage, and aneuploidy are the best markers of progression in organ confined disease. Other biological markers are less important. In advanced disease Gleason score and nuclear morphometry can be used as predictors of progression. Compound prognostic factors based on combinations of single prognosticators, or on gene expression profiles (tested by DNA arrays) are promising, but clinically relevant data is still lacking

MHD electrode development. Quarterly report, April-June 30, 1980

Emphasis within this program is now being directed towards the engineering development of cold metallic electrodes, and in particular the identification and evaluation of alternatives to platinum for use as anodes. A literature search, concentrating on hot corrosion resistant alloys, has been undertaken and results are presented. In addition, results of platinum-copper diffusion studies and a preliminary evaluation of sputter coated specimens of TiB/sub 2/ clad copper are reported. Laboratory anode arc erosion studies have continued. A number of modifications incorporated in the test setup are described. This modified test arrangement has been used to obtain comparative data on a number of potential anode metal alloys. Further work is required to refine the test, particularly to provide a reliable method of applying corrodent to the specimens under test. No significant laboratory electrochemical corrosion tests were completed during this reporting period. Facility test operations were suspended upon completion of WESTF Test 49 during the prior quarter to permit basic facility modifications in support of the addition of a 3 Tesla magnet. The status of design, procurement and modification activities is presented