Thermal equation of state of polarized fermions in one dimension via complex chemical potentials

We present a nonperturbative computation of the equation of state of polarized, attractively interacting, nonrelativistic fermions in one spatial dimension at finite temperature. We show results for the density, spin magnetization, magnetic susceptibility, and Tan's contact. We compare with the second-order virial expansion, a next-to-leading-order lattice perturbation theory calculation, and interpret our results in terms of pairing correlations. Our lattice Monte Carlo calculations implement an imaginary chemical potential difference to avoid the sign problem. The thermodynamic results on the imaginary side are analytically continued to obtain results on the real axis. We focus on an intermediate- to strong-coupling regime, and cover a wide range of temperatures and spin imbalances

Immune phenotypes predict survival in patients with glioblastoma multiforme

Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patients with GBM. Methods: Immune phenotypes and plasma biomarkers of GBM patients were determined at the time of diagnosis using flow cytometry and ELISA, respectively. Results: Using descriptive statistics, we found that immune anomalies were distinct in individual patients. Defined marker profiles proved highly relevant for survival. A remarkable relation between activated NK cells and improved survival in GBM patients was in contrast to increased CD39 and IL-10 in patients with a detrimental course and very short survival. Recursive partitioning analysis (RPA) and Cox proportional hazards models substantiated the relevance of absolute numbers of CD8 cells and low numbers of CD39 cells for better survival. Conclusions: Defined alterations of the immune system may guide the course of disease in patients with GBM and may be prognostically valuable for longitudinal studies or can be applied for immune intervention

Aligned-spin neutron-star–black-hole waveform model based on the effective-one-body approach and numerical-relativity simulations

After the discovery of gravitational waves from binary black holes (BBHs) and binary neutron stars (BNSs) with the LIGO and Virgo detectors, neutron-star black holes (NSBHs) are the natural next class of binary systems to be observed. In this work, we develop a waveform model for aligned-spin NSBHs combining a BBH baseline waveform (available in the effective-one-body approach) with a phenomenological description of tidal effects (extracted from numerical-relativity simulations) and correcting the amplitude during the late inspiral, merger and ringdown to account for the NS tidal disruption. In particular, we calibrate the amplitude corrections using NSBH waveforms obtained with the numerical-relativity spectral Einstein code (SpEC) and the SACRA code. The model was calibrated using simulations with NS masses in the range 1.2–1.4  M⊙, tidal deformabilities up to 4200 (for a 1.2  M⊙ NS), and dimensionless BH spin magnitude up to 0.9. Based on the simulations used and on checking that sensible waveforms are produced, we recommend our model to be employed with a NS mass in the range 1–3  M⊙, tidal deformability 0–5000, and (dimensionless) BH spin magnitude up to 0.9. We also validate our model against two new, highly accurate NSBH waveforms with BH spin 0.9 and mass ratios 3 and 4, characterized by tidal disruption, produced with SpEC, and find very good agreement. Furthermore, we compute the unfaithfulness between waveforms from NSBH, BBH, and BNS systems, finding that it will be challenging for the Advanced LIGO-Virgo detector network at design sensitivity to distinguish different source classes. We perform a Bayesian parameter-estimation analysis on a synthetic numerical-relativity signal in zero noise to study parameter biases. Finally, we reanalyze GW170817, with the hypothesis that it is a NSBH. We do not find evidence to distinguish the BNS and NSBH hypotheses; however, the posterior for the mass ratio is shifted to less equal masses under the NSBH hypothesis

Contemporary geomorphological activity throughout the proglacial area of an alpine catchment

Quantification of contemporary geomorphological activity is a fundamental prerequisite for predicting the effects of future earth surface process and landscape development changes. However, there is a lack of high-resolution spatial and temporal data on geomorphological activity within alpine catchments, which are especially sensitive to climate change, human impacts and which are amongst the most dynamic landscapes on Earth. This study used data from repeated laser scanning to identify and quantify the distribution of contemporary sediment sources and the intensity of geomorphological activity within the lower part of a glaciated alpine catchment; Ödenwinkelkees, central Austria. Spatially, geomorphological activity was discriminated by substrate class. Activity decreased in both areal extent and intensity with distance from the glacier, becoming progressively more restricted to the fluvially-dominated valley floor. Temporally, geomorphological activity was identified on annual, seasonal, weekly and daily timescales. Activity became more extensive with increasing study duration but more intense over shorter timescales, thereby demonstrating the importance of temporary storage of sediment within the catchment. The mean volume of material moved within the proglacial zone was 4400m.yr, which suggests a net surface lowering of 34mm.yr in this part of the catchment. We extrapolate a minimum of 4.8mm.yr net surface lowering across the whole catchment. These surface lowering values are approximately twice those calculated elsewhere from contemporary measurements of suspended sediment flux, and of rates calculated from the geological record, perhaps because we measure total geomorphological activity within the catchment rather than overall efflux of material. Repeated geomorphological surveying therefore appears to mitigate the problems of hydrological studies underestimating sediment fluxes on decadal-annual time-scales. Further development of the approach outlined in this study will enable the quantification of geomorphological activity, alpine terrain stability and persistence of landforms

An aligned-spin neutron-star--black-hole waveform model based on the effective-one-body approach and numerical-relativity simulations

After the discovery of gravitational waves from binary black holes (BBHs) and binary neutron stars (BNSs) with the LIGO and Virgo detectors, neutron-star--black-holes (NSBHs) are the natural next class of binary systems to be observed. In this work, we develop a waveform model for aligned-spin neutron-star--black-holes (NSBHs) combining a binary black-hole baseline waveform (available in the effective-one-body approach) with a phenomenological description of tidal effects (extracted from numerical-relativity simulations), and correcting the amplitude during the late inspiral, merger and ringdown to account for the NS's tidal disruption. In particular, we calibrate the amplitude corrections using NSBH waveforms obtained with the numerical-relativity spectral Einstein code (SpEC) and the SACRA code. Based on the simulations used, and on checking that sensible waveforms are produced, we recommend our model to be employed with NS's mass in the range $1-3 M_\odot$, tidal deformability 0\mbox{-}5000, and (dimensionless) BH's spin magnitude up to $0.9$. We also validate our model against two new, highly accurate NSBH waveforms with BH's spin 0.9 and mass ratios 3 and 4, characterized by tidal disruption, produced with SpEC, and find very good agreement. Furthermore, we compute the unfaithfulness between waveforms from NSBH, BBH, and BNS systems, finding that it will be challenging for the advanced LIGO-Virgo--detector network at design sensitivity to distinguish different source classes. We perform a Bayesian parameter-estimation analysis on a synthetic numerical-relativity signal in zero noise to study parameter biases. Finally, we reanalyze GW170817, with the hypothesis that it is a NSBH. We do not find evidence to distinguish the BNS and NSBH hypotheses, however the posterior for the mass ratio is shifted to less equal masses under the NSBH hypothesis.Comment: 18 pages, 10 Figure

Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of ventilator-associated pneumonia (VAP). Patients with VAP have poorly functioning neutrophils, related to increased levels of the complement fragment C5a. The antibiotic linezolid has been useful in controlling MRSA-related VAP infections; however clinical benefit does not always correlate with antimicrobial effect, suggesting the possibility of immunomodulatory properties. Here the effects of linezolid on healthy and dysfunctional neutrophils (modelled by C5a-induced injury) was investigated. Functional assays (killing, phagocytosis, transmigration, and respiratory burst) were used to assess the effects of pre-, co- and post-incubating linezolid (0.4–40 mg/L) with healthy neutrophils relative to those with C5a-induced injury. C5a decreased neutrophil killing, and phagocytosis of MRSA. Furthermore, C5a significantly decreased neutrophil transmigration to IL-8, but did not affect respiratory burst. Co-incubation of linezolid significantly improved killing of MRSA by dysfunctional neutrophils, which was supported by concomitant increases in phagocytosis. Conversely linezolid impaired killing responses in healthy neutrophils. Pre- or post-incubation of linezolid prior or following C5a induced injury had no effect on neutrophil function. This study suggests that linezolid has immunomodulatory properties that protect human neutrophils from injury and provides insight into its mode of action beyond a basic antibiotic

Physical and mental effort disrupts the implicit sense of agency

We investigated the effect of effort on implicit agency ascription for actions performed under varying levels of physical effort or cognitive load. People are able to estimate the interval between two events accurately, but they underestimate the interval between their own actions and their outcomes. This effect is known as ‘intentional binding’, and may provide feedback regarding the consequences of our actions. Concurrently with the interval reproduction task, our participants pulled sports resistance bands at high and low resistance levels (Experiments 1 and 2), or performed a working memory task with high and low set-sizes (Experiment 3). Intentional binding was greater under low than high effort. When the effort was task-related (Experiment 1), this effect depended on the individual’s explicit appraisal of exertion, while the effect of effort was evident at the group level when the effort was task-unrelated (physical, Experiment 2; mental, Experiment 3). These findings imply that the process of intentional binding is compromised when cognitive resources are depleted, either through physical or mental strain. We discuss this notion in relation to the integration of direct sensorimotor feedback with signals of agency and other instances of cognitive resource depletion and action control during strain

On Dorsal Prothoracic Appendages in Treehoppers (Hemiptera: Membracidae) and the Nature of Morphological Evidence

A spectacular hypothesis was published recently, which suggested that the “helmet” (a dorsal thoracic sclerite that obscures most of the body) of treehoppers (Insecta: Hemiptera: Membracidae) is connected to the 1st thoracic segment (T1; prothorax) via a jointed articulation and therefore was a true appendage. Furthermore, the “helmet” was interpreted to share multiple characteristics with wings, which in extant pterygote insects are present only on the 2nd (T2) and 3rd (T3) thoracic segments. In this context, the “helmet” could be considered an evolutionary novelty. Although multiple lines of morphological evidence putatively supported the “helmet”-wing homology, the relationship of the “helmet” to other thoracic sclerites and muscles remained unclear. Our observations of exemplar thoraces of 10 hemipteran families reveal multiple misinterpretations relevant to the “helmet”-wing homology hypothesis as originally conceived: 1) the “helmet” actually represents T1 (excluding the fore legs); 2) the “T1 tergum” is actually the anterior dorsal area of T2; 3) the putative articulation between the “helmet” and T1 is actually the articulation between T1 and T2. We conclude that there is no dorsal, articulated appendage on the membracid T1. Although the posterior, flattened, cuticular evagination (PFE) of the membracid T1 does share structural and genetic attributes with wings, the PFE is actually widely distributed across Hemiptera. Hence, the presence of this structure in Membracidae is not an evolutionary novelty for this clade. We discuss this new interpretation of the membracid T1 and the challenges of interpreting and representing morphological data more broadly. We acknowledge that the lack of data standards for morphology is a contributing factor to misinterpreted results and offer an example for how one can reduce ambiguity in morphology by referencing anatomical concepts in published ontologies