Мониторинг опасных геологических процессов на территории г. Томска

International audienceTo assess the accuracy and signal quality of axial length measurements by partial coherence laser interferometry (PCI) for optical biometry in eyes with conventional (SO) or heavy silicone oil (HSO) as endotamponade

Synthetic lethal therapies for cancer: what's next after PARP inhibitors?

The genetic concept of synthetic lethality has now been validated clinically through the demonstrated efficacy of poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of cancers in individuals with germline loss-of-function mutations in either BRCA1 or BRCA2. Three different PARP inhibitors have now been approved for the treatment of patients with BRCA-mutant ovarian cancer and one for those with BRCA-mutant breast cancer; these agents have also shown promising results in patients with BRCA-mutant prostate cancer. Here, we describe a number of other synthetic lethal interactions that have been discovered in cancer. We discuss some of the underlying principles that might increase the likelihood of clinical efficacy and how new computational and experimental approaches are now facilitating the discovery and validation of synthetic lethal interactions. Finally, we make suggestions on possible future directions and challenges facing researchers in this field

Glaucoma surgery in children

Goniotomy has been established as the standard procedure in the treatment of congenital glaucoma for more than 50 years. This article presents the current indications for the different antiglaucomatous procedures in children with success rates and specific complications. A selective literature search was carried out and a report of the consensus meeting 2013 concerning congenital glaucoma and personal experiences are presented. Primary surgical treatment for primary congenital glaucoma mainly consists of trabeculotomy and its modifications but also of goniotomy. A widespread and increasing use of drainage device surgery can be seen in complicated types of pediatric glaucoma, such as secondary glaucoma due to aphakia, uveitis or Sturge-Weber-Krabbe syndrome. The visual prognosis following glaucoma surgery generally depends on successful control of the intraocular pressure as well as on amblyopia treatment

Revision surgery in episcleral glaucoma drainage devices

Episcleral glaucoma drainage devices (e.g., Ahmed or Baerveldt drainage device) are often used at a late stage in the care of glaucoma patients. At this stage other surgical techniques, such as trabeculectomy or viscocanaloplasty, have failed. However, the trend towards earlier implant surgery is supported by large randomized trials. Physicians should be aware of typical complications and, if possible, these should already be avoided by careful surgical technique. In this review article, we focus on postoperative hypotension, postoperative pressure increases, implant exposure, and possible corneal decompensation