Kinesio taping application in a pediatric patient with spinal muscular atrophy

Kinesio taping is one of the elastic bandage methods which has been quite popular in the last 20 years and has been applied in various musculoskeletal conditions. Although the mechanism of action is not clear, many theories have been suggested so far. In this case report, we aimed to present the results of kinesiotape application for back pain of the patient with spinal muscular atrophy which is one of the progressive muscular disorders. It was performed for three times with four days interval. Fascial technique B (Space technique) was applied. Reduce of pain was also observed during the subsequent applications. The application of kinesio taping could be beneficial on reducing the pain in patients with progressive muscle diseases. [Cukurova Med J 2016; 41(2.000): 386-389

Reactive Arthritis

Reactive arthritis is an acute, sterile, non-suppurative and inflammatory arthropaty which has occured as a result of an infectious processes, mostly after gastrointestinal and genitourinary tract infections. Reiter syndrome is a frequent type of reactive arthritis. Both reactive arthritis and Reiter syndrome belong to the group of seronegative spondyloarthropathies, associated with HLA-B27 positivity and characterized by ongoing inflammation after an infectious episode. The classical triad of Reiter syndrome is defined as arthritis, conjuctivitis and urethritis and is seen only in one third of patients with Reiter syndrome. Recently, seronegative asymmetric arthritis and typical extraarticular involvement are thought to be adequate for the diagnosis. However, there is no established criteria for the diagnosis of reactive arthritis and the number of randomized and controlled studies about the therapy is not enough. [Archives Medical Review Journal 2013; 22(3.000): 283-299

Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy

Background: In breast cancer treatment, aromatase inhibitors (AI) and tamoxifen (Tmx) are frequently used. In this study, the relationship between the hormonal therapy and arthralgia in women with breast cancer was studied. Methods: Sixty-four patients of whom 32 taking AI and 32 taking Tmx were included into the study. VAS was used to determine the intensity of pain. Also five options Likert scale was applied to all patients to answer the question “what are your thoughts about the sources of your current pain?”. As laboratory parameters, CBC, BUN creatinine, ALT, AST, alkaline phosphatase, calcium, CRP, ESR, ANA, RF, and estradiol levels of the patients were analyzed. Results: The mean age of the AI group was 52.7 ± 8.2 years and in the Tmx group, it was 47.4 ± 6.5 years (p0.05, for each). Conclusion: In our study, more frequent and severe arthralgia has been observed in patients under AI treatment when compared to tamoxifen. One of the causes that leads to arthralgia in patients using AI may be low levels of estradiol. [Cukurova Med J 2013; 38(1.000): 78-85

Serum eosinophil cationic protein levels in Behcet's disease and its relation to clinical activity

WOS: 000325120000010PubMed ID: 23517396Background: Eosinophil cationic protein (ECP) is a matrix protein of eosinophils and has been reported to reflect eosinophil activity. Few studies have examined the role of eosinophils in the pathogenesis of Behcet's disease. Objective: The purpose of the present study was to investigate the serum ECP levels in BD and its relation to clinical activity. Methods: Forty-seven consecutive patients with BD (22 active, 25 inactive), 21 age and sex matched patients with allergic rhinitis and 21 healthy controls were evaluated cross-sectionally. The serum ECP levels were measured by the flourescein enzyme immunoassay method. Results: Mean serum ECP levels of active patients with BD (34.28 +/- 23.43 mu g/L) were found to be significantly lower than those of the inactive patients (65.69 +/- 46.32 mu g/L, p <0.05) and the controls (62.92 +/- 30.49 mu g/L, p <0.01). Behcet patients with oral aphthous lesions had significantly lower mean serum ECP levels (n=21, 38.82 +/- 33.38 mu g/L) than those without aphthous lesions (n=26, 60.81 +/- 43.21 mu g/L) (p = 0.041). Similarly patients with arthritis had lower serum ECP values (n=6, 22.12 +/- 9.47 mu g/L) than those without arthritis (n = 41, 55.21 +/- 41.35 mu g/L) (p =0.029). Conclusions: Lower ECP levels in the active phase of the disease may be a result of decreased production due to the activation of Th1 cytokines.Cukurova University Researh FundCukurova University [TF.00.U.32]The study was funded by Cukurova University Researh Fund, project number TF.00.U.32

Charcot's neuroarthropathy of the hand in a patient with diabetes mellitus

WOS: 000384674200014PubMed ID: 27075802Charcot's neuroarthropathy (CNA) is a destructive disease associated with a reduced proprioceptive sensation. Diabetes mellitus (DM) is one of the most common etiological factor for CNA which typically affects ankles and small joints of feet. Neuroarthropathy seen in upper extremity in patients with DM is a rare clinical condition.In this report, we presented a case of CNA with hand involvement who had type-II DM. Neuroarthropathy was rapidly progressed and destructive changes were observed in right hand joints after a minor trauma in current case.Charcot's neuroarthropathy may rarely occur in the joints of hand in patients with DM. Early diagnosis of CNA is important in order to protect joints and avoid further disability

A rare cause of cutanous vasculitis: Anastrosole

Breast cancer is the most frequently diagnosed type of cancer and the foremost reason of the death of women from cancer. Hormone receptor positive breast cancer is the most frequent type of breast cancer. Anastrosole is one of the aromatase inhibitors which is indicated for early stage of hormone receptor positive breast cancer of postmenopausal women. A 67-year-old woman was refered to Rheumatology Department from Medical Oncology Department for skin rashes which have started 3 months ago. In her medical history, she was diagnosed as infiltrative ductal carcinoma grade-2 in the right breast. She had a modified radical mastectomy operation for the right breast and subsequently, anastrosole was started as her hormone receptor was found positive in histopathological examination. The drug was stopped after 5 years by her oncologist however she went on using the drug on her own demand. Three months before her referral, non-itchy, painless reddish rash was started on legs and arms. After careful physical and laboratory examination and histopathologic alevaluation, she was diagnosed as middle-vessel necrotising vasculitis. Anastrosole was stopped. Steroid and azathyoprine were started. On the fifth month of therapy, all skin lesions were resolved with postinflammatory hyperpigmentation. No additional problem was met. This case report is suggesting that, anastrosole which is a frequently preferred agent in recentyears, could also cause leucocytoclastic vasculits. Very rare cases with cutanous vasculitis were previously presented. This case report suggests that, during the management of patients under anastrosole therapy, cutanous vasculitis should be monitored carefully. [Cukurova Med J 2014; 39(2.000): 369-372

Evaluation of Doxorubicin Cardiomyopathy by Signal Averaged Electrocardiography

BACKGROUND: Signal-averaged electrocardiography detects low-amplitude signals designated as late potentials which are strongly related to myocardial damage. We aimed to search for the possible relation between the myocardial effects of doxorubicin and signal-averaged electrocardiographic parameters. METHODS: Fortyeight patients who received doxorubicin included chemotherapy were enrolled. Signal-averaged electrocardiographic parameters were detected by using 3 parameters; filtered QRS (fQRS), the square root of the voltage obtained during the last 40 milliseconds of the duration of fQRS (RMS40), the duration starting from the last 40 miliseconds of fQRS till the decrease of voltage under 40 microvolts. (HFLA40). Ejection fractions of the patients were measured by echocardiographic evaluation. RESULTS: Median age was 44 (27-70) years. Mean cumulative doxorubicin dosage was 475.56&#177;98.45 mg. Mean values of the measured signal-averaged electrocardiographic parameters were as follows; fQRS: 78.27&#177;10.74 miliseconds, RMS40:115.10&#177;50.23 and HFLA was 21.95&#177;8.39 microvolts . The doses of doxorubicin showed a positive correlation with fQRS (r=0.28, p=0.02) and a negative correlation with RMS40 (r=-.31,p=0.03). There was no correlation between the doxorubicin dosage and the ejection fraction of the patients (r=.18, p=0.22). CONCLUSION: Our results suggested that significant correlations are present between fQRS and RMS40 and cumulative doxorubicin dosages. Therefore, signal-averaged electrocardiographic parameters may be of value for predicting the prognosis of the patients who have received doxorubicin included chemotherapy. [Cukurova Med J 2013; 38(2.000): 241-249

Severe Respiratory Failure in the Coexistence of Polymyositis and Hypothyroidism: A Case Report

Polymyositis is a systemic, inflammatory muscle disease. Respiratory insufficiency as a result of respiratory muscle involvement could also be observed. Here we report a fortyone-year-old man who attended to the hospital with the complaints of shortness of breath and chest pain that have suddenly started. Physical examination has revealed proximal muscle weakness. Serum creatinine phosphokinase level has increased, ANA was positive and the electromyographic examination has revealed myopathic changes. Deltoid muscle biopsy was in accordance with polymyositis. Methyl-prednisolone 1 gram iv pulse therapy was given during the first 5 days. He was started with 25 mg/week parenteral methotrexate. Laboratory tests suggested hypothyroidism and levothyroxine replacement therapy was started. The clinical findings have improved concomitant with the reduction in the muscle enzymes and thyroid stimulant hormone levels into the normal ranges. He was discharged with the recommendation of the NIMV device application during night-time. The clinical symptoms are more severe in the presence of alveolar hypoventilation due to polymyositis and coincidantal hypothyroidism. [Cukurova Med J 2013; 38(4.000): 744-750

Periodic Fever and Hyperimmunoglobulin D Syndrome in a Boy with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Group A beta-Hemolytic Streptococcus

WOS: 000319256600011PubMed ID: 23647138

KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR GENOTYPE DISTRIBUTION IN FAMILIAL MEDITERRANEAN FEVER: NO ASSOCIATION WITH DISEASE PHENOTYPE AND RENAL AMYLOIDOSIS

52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation -- MAY 28-31, 2015 -- London, ENGLANDWOS: 000361215101452…European Renal Assoc, European Dialysis & Transplant Asso