Hsp70 in mitochondrial biogenesis

The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non-native conformations at distinct stages during their life in the cell. In this paper we review work pertaining to the functions of hsp70 proteins in chaperoning mitochondrial protein biogenesis. Hsp70 proteins function in protein synthesis, protein translocation across mitochondrial membranes, protein folding and finally the delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix

Unifying Thread-Level Speculation and Transactional Memory ⋆

Abstract. The motivation of this work is to ask whether Transactional Memory (TM) and Thread-Level Speculation (TLS), two prominent concurrency paradigms usually considered separately, can be combined into a hybrid approach that extracts untapped parallelism and speed-up from common programs. We show that the answer is positive by describing an algorithm, called TLSTM, that leverages an existing TM with TLS capabilities. We also show that our approach is able to achieve up to a 48 % increase in throughput over the base TM, on read dominated workloads of long transactions in a multi-threaded application.