Effects of Bulk Viscosity on Cosmological Evolution

The effect of bulk viscisity on the evolution of the homogeneous and isotropic cosmological models is considered. Solutions are found, with a barotropic equation of state, and a viscosity coefficient that is proportional to a power of the energy density of the universe. For flat space, power law expansions, related to extended inflation are found as well as exponential solutions, related to old inflation; also a solution with expansion that is an exponential of an exponential of the time is found.Comment: 8 pages, latex, no figure

On the Proof of Dark Matter, the Law of Gravity and the Mass of Neutrinos

We develop a new method to predict the density associated with weak lensing maps of (un)relaxed clusters in a range of theories interpolating between GR and MOND (General Relativity and Modified Newtonian Dynamics). We apply it to fit the lensing map of the bullet merging cluster 1E0657-56, in order to constrain more robustly the nature and amount of collisionless matter in clusters {\it beyond} the usual assumption of spherical equilibrium (Pointecouteau & Silk 2005) and the validity of GR on cluster scales (Clowe et al. 2006). Strengthening the proposal of previous authors we show that the bullet cluster is dominated by a collisionless -- most probably non-baryonic -- component in GR as well as in MOND, a result consistent with the dynamics of many X-ray clusters. Our findings add to the number of known pathologies for a purely baryonic MOND, including its inability to fit the latest data from the Wilkinson Microwave Anisotropy Probe. A plausible resolution of all these issues and standard issues of Cold Dark Matter with galaxy rotation curves is the "marriage" of MOND with ordinary hot neutrinos of 2eV. This prediction is just within the GR-independent maximum of neutrino mass from current $\beta$-decay experiments, and is falsifiable by the Karlsruhe Tritium Neutrino (KATRIN) experiment by 2009. Issues of consistency with strong lensing arcs and the large relative velocity of the two clusters comprising the bullet cluster are also addressed.Comment: 4 pages, 1 figure, accepted for publication in ApJL. Added a simple model of the bullet cluster's high velocity in TeVeS, and discussions of sterile neutrinos and of non-uniqueness of the lensing deprojectio

Effect of the Diesel, Inhibitor, and CO 2

In order to determine the diesel contribution in the coadsorption process of the oil-soluble inhibitors, electrochemical impedance spectroscopy measurements have been carried out to study the performance of oil-soluble inhibitors in both presence and absence of diesel and CO2. The results showed that the presence of the oil phase provides some protection to the steel because the water-soluble fractions are capable of being adsorbed on the steel surface thereby reducing the corrosion rate. The oily phase does not contribute to the adsorption process of the inhibitor because the inhibitor is absorbed into the water-soluble fractions. The oil-soluble inhibitors are effective only when the solution is saturated with CO2. CO2 saturation causes a decrease in the pH of the solution causing both an increase of the inhibitor solubility and a better dispersion of the inhibitor into the electrolyte

Secukinumab demonstrates superiority over narrow-band ultraviolet B phototherapy in new-onset moderate to severe plaque psoriasis patients: Week 52 results from the STEPIn study.

Biologic treatments have been studied mainly in patients with a long-term history of psoriasis and previous treatment failures. The purpose of this primary analysis of the STEPIn study is to determine whether early intervention with secukinumab in patients with new-onset moderate to severe plaque psoriasis is superior to standard of care treatment with narrow band ultraviolet B (nb-UVB) phototherapy. The STEPIn study is a randomized, open-label, multicentre study to investigate early intervention with 52 weeks of secukinumab 300 mg administered subcutaneously versus standard treatment with nb-UVB phototherapy in patients with new-onset (≤12 months) moderate to severe plaque psoriasis (NCT03020199). The primary and additional secondary endpoints were ≥90% improvement in Psoriasis Area and Severity Index (PASI 90) at Week 52 and Investigator's Global Assessment (IGA mod 2011) 0/1 response at Week 52, respectively. In the secukinumab and nb-UVB study arms, 77/80 and 76/80 randomized patients received at least one dose of study treatment, respectively. The primary endpoint was achieved: 91.1% (70/77) of patients achieved a PASI 90 response at Week 52 in the secukinumab arm versus 42.3% (32/76) in the nb-UVB arm (p < 0.0001, odds ratio [OR] estimate [95% confidence intervals, CI] = 16.3 [5.6, 46.9]). The additional secondary endpoint was also achieved: 85.7% of patients achieved an IGA 0/1 response at Week 52 in the secukinumab arm versus 36.8% in the nb-UVB arm (p < 0.0001). The safety data were consistent with the safety profiles of secukinumab and nb-UVB with no new or unexpected safety signals. Secukinumab was superior to nb-UVB in treating patients with new-onset moderate to severe plaque psoriasis. The high and sustained skin clearance observed indicates that biologic treatment for psoriasis may be more effective if used early in the disease course

In silico selection and in vitro evaluation of new molecules that inhibit the adhesion of Streptococcus mutans through Antigen I/II

Streptococcus mutans is the main early colonizing cariogenic bacteria because it recognizes salivary pellicle receptors. The Antigen I/II of S. mutans is one of the most important adhesins in this process, is involved in the adhesion to the tooth surface and the bacterial co-aggregation in the early stage of biofilm formation. However, this protein has not been used as a target in a virtual strategy search for inhibitors. Based on the predicted binding affinities, drug-like properties and toxicity, molecules were selected and evaluated for their ability to reduce S. mutans adhesion. A virtual screening of 883,551 molecules was conducted, cytotoxicity analysis on fibroblast cells, S. mutans adhesion studies, scanning electron microscopy analysis for bacterial integrity and molecular dynamics simulation were also performed. We have found three molecules (ZI-187, ZI-939, ZI-906) without cytotoxic activity, which inhibited about 90% the adhesion of S. mutans to polystyrene microplates. Molecular dynamic simulation by 300 nanoseconds showed stability of the interaction between ZI-187 and Ag I/II (PDB: 3IPK). This work provides new molecules that targets Ag I/II and have the capacity to inhibit in vitro the S. mutans adhesion on polystyrene microplates

Bianchi I Quantum cosmology in the Bergmann-Wagoner theory

The Wheeler-DeWitt equation is considered in the context of generalized scalar-tensor theories of gravitation for Bianchi type I cosmology. Exact solutions are found for two selfinteracting potentials and arbitary coupling function. The WKB wavefunctions are obtained and a family of solutions satisfying the Hawking-Page regularity conditions of wormholes are found.Comment: 12 pages, Latex fil

Feminist Pedagogy in the STEM Research Laboratory: an Intersectional Approach

The research laboratory is a crucial and indispensable classroom for STEM education. It is where we practice science as a craft and test the ideas that awaken our curiosity, allowing us to create knowledge. It is also a space where challenges await and struggles are imminent. Thus, supporting mentees through their traineeship in a research lab requires an intersectional approach and lens to provide equitable mentorship and guidance. The concept of intersectionality, initially devised by Black feminist professor Kimberlé W. Crenshaw, can be employed to generate practices and frameworks that democratize laboratory culture and provide trainees with a space in which they shape the laboratory culture while helping them recognize their positionality. This critical commentary provides insights and experiences when incorporating feminist frameworks to sustain equitable working environments in the research lab setting, specifically in leading a research group composed predominantly of Puerto Rican women

Hypertrophic Cardiomyopathy Diagnosis and Treatment in High- and Low-Income Countries: A Narrative Review

Hypertrophic cardiomyopathy (HCM) is a hereditary cardiac condition characterized by unexplained left ventricular hypertrophy without a hemodynamic cause. This condition is prevalent in the United States, resulting in various clinical manifestations, including diastolic dysfunction, left ventricular outflow obstruction, cardiac ischemia, and atrial fibrillation. HCM is associated with several genetic mutations, with sarcomeric mutations being the most common and contributing to a more complex disease course. Early diagnosis of HCM is essential for effective management, as late diagnosis often requires invasive treatments and creates a substantial financial burden. Disparities in HCM diagnosis and treatment exist between highincome and low-income countries. High-income countries have more resources to investigate and implement advanced diagnostic and treatment modalities. In contrast, low-income countries face challenges in accessing diagnostic equipment, trained personnel, and affordable medications, leading to a lower quality of life and life expectancy for affected individuals. Diagnostic tools for HCM include imaging studies such as 2D echocardiography, cardiovascular magnetic resonance (CMR), and electrocardiograms (ECGs). CMR is considered the gold standard but remains inaccessible to a significant portion of the world\u27s population, especially in low-income countries. Genetics plays a crucial role in HCM, with numerous mutations identified in various genes. Genetic counseling is essential but often limited in low-income countries due to resource constraints. Disparities in healthcare access and adherence to treatment recommendations exist between high-income and low-income countries, leading to differences in patient outcomes. Addressing these disparities is essential to improve the overall management of HCM on a global scale. In conclusion, this review highlights the complex nature of HCM, emphasizing the importance of early diagnosis, genetic counseling, and access to appropriate diagnostic and therapeutic interventions. Addressing healthcare disparities is crucial to ensure that all individuals with HCM receive timely and effective care, regardless of their geographic location or socioeconomic status

Mineralisation of surfactants using ultrasound and the Advanced Fenton Process

The destruction of the surfactants, sodium dodecylbenzene sulfonate (DBS) and dodecyl pyridinium chloride (DPC), using an advanced oxidation process is described. The use of zero valent iron (ZVI) and hydrogen peroxide at pH = 2.5 (the advanced Fenton process), with and without, the application of 20 kHz ultrasound leads to extensive mineralisation of both materials as determined by total organic carbon (TOC)measurements. For DBS, merely stirring with ZVI and H2O2 at 20°C leads to a 51% decrease in TOC, but using 20 kHz ultrasound at 40°C, maintaining the pH at 2.5 throughout and adding extra amounts of ZVI and H2O2 during the degradation, then the extent of mineralisation of DBS is substantially increased to 93%. A similar result is seen for DPC where virtually no degradation occurs at 20°C, but if extra amounts of both ZVI and hydrogen peroxide are introduced during the reaction at 40°C and the pH is maintained at 2.5, then an 87% mineralisation of DPC is obtained. The slow latent remediation of both surfactants and the mechanism of degradation are also discussed