Classifying continuous, real-time e-nose sensor data using a bio-inspired spiking network modelled on the insect olfactory system

In many application domains, conventional e-noses are frequently outperformed in both speed and accuracy by their biological counterparts. Exploring potential bio-inspired improvements, we note a number of neuronal network models have demonstrated some success in classifying static datasets by abstracting the insect olfactory system. However, these designs remain largely unproven in practical settings, where sensor data is real-time, continuous, potentially noisy, lacks a precise onset signal and accurate classification requires the inclusion of temporal aspects into the feature set. This investigation therefore seeks to inform and develop the potential and suitability of biomimetic classifiers for use with typical real-world sensor data. Taking a generic classifier design inspired by the inhibition and competition in the insect antennal lobe, we apply it to identifying 20 individual chemical odours from the timeseries of responses of metal oxide sensors. We show that four out of twelve available sensors and the first 30 s(10%) of the sensors’ continuous response are sufficient to deliver 92% accurate classification without access to an odour onset signal. In contrast to previous approaches, once training is complete, sensor signals can be fed continuously into the classifier without requiring discretization. We conclude that for continuous data there may be a conceptual advantage in using spiking networks, in particular where time is an essential component of computation. Classification was achieved in real time using a GPU-accelerated spiking neural network simulator developed in our group

Polarization morphology of SiO masers in the circumstellar envelope of the AGB star R Cassiopeiae

Silicon monoxide maser emission has been detected in the circumstellar envelopes of many evolved stars in various vibrationally-excited rotational transitions. It is considered a good tracer of the wind dynamics close to the photosphere of the star. We have investigated the polarization morphology in the circumstellar envelope of an AGB star, R Cas. We mapped the linear and circular polarization of SiO masers in the v=1, J=1-0 transition. The linear polarization is typically a few tens of percent while the circular polarization is a few percent. The fractional polarization tends to be higher for emission of lower total intensity. We found that, in some isolated features the fractional linear polarization appears to exceed 100%. We found the Faraday rotation is not negligible but is ~15 deg., which could produce small scale structure in polarized emission whilst total intensity is smoother and partly resolved out. The polarization angles vary considerably from feature to feature but there is a tendency to favour the directions parallel or perpendicular to the radial direction with respect to the star. In some features, the polarization angle abruptly flips 90 deg. We found that our data are in the regime where the model of Goldreich et al (1973) can be applied and the polarization angle flip is caused when the magnetic field is at close to 55 deg. to the line of sight. The polarization angle configuration is consistent with a radial magnetic field although other configurations are not excluded.Comment: 14 pages, 15 figures. Accepted for publication in MNRA

A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis

The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F) of the West Nile virus (WNV) E protein domain I-II hinge that regulates virus breathing. The T198F mutation resulted in a ~70-fold increase in sensitivity to neutralization by a monoclonal antibody targeting a cryptic epitope in the fusion loop. Increased exposure of this otherwise poorly accessible fusion loop epitope was accompanied by reduced virus stability in solution at physiological temperatures. Introduction of a mutation at the analogous residue of dengue virus (DENV), but not Zika virus (ZIKV), E protein also increased accessibility of the cryptic fusion loop epitope and decreased virus stability in solution, suggesting that this residue modulates the structural ensembles sampled by distinct flaviviruses at equilibrium in a context dependent manner. Although the T198F mutation did not substantially impair WNV growth kinetics in vitro, studies in mice revealed attenuation of WNV T198F infection. Overall, our study provides insight into the molecular basis and the in vitro and in vivo consequences of flavivirus breathing

The opposites task: Using general rules to test cognitive flexibility in preschoolers

A brief narrative description of the journal article, document, or resource. Executive functions play an important role in cognitive development, and during the preschool years especially, children's performance is limited in tasks that demand flexibility in their behavior. We asked whether preschoolers would exhibit limitations when they are required to apply a general rule in the context of novel stimuli on every trial (the "opposites" task). Two types of inhibitory processing were measured: response interference (resistance to interference from a competing response) and proactive interference (resistance to interference from a previously relevant rule). Group data show 3-year-olds have difficulty inhibiting prepotent tendencies under these conditions, whereas 5-year-olds' accuracy is near ceiling in the task. (Contains 4 footnotes and 1 table.

A MERLIN Study of 6 GHz Excited-state OH & 6.7 GHz Methanol Masers in ON1

MERLIN observations of 6.668-GHz methanol and both 6.031- and 6.035-GHz hydroxyl (OH) emission from the massive star-formation region ON1 are presented. These are the first methanol observations made in full polarization using 5 antennas of MERLIN, giving high resolution and sensitivity to extended emission. Maser features are found to lie at the southern edge of the ultra-compact HII region, following the known distribution of ground-state OH masers. The masers cover a region ~1 arcsec in extent, lying perpendicular to the H13CO+ bipolar outflow. Excited-state OH emission demonstrates consistent polarization angles across the strongest linearly polarized features which are parallel to the overall distribution. The linear polarizations vary between 10.0 and 18.5 per cent, with an average polarization angle of -60 deg +/- 28 deg. The strongest 6.668-GHz methanol features provide an upper limit to linear polarization of ~1 per cent. Zeeman splitting of OH shows magnetic fields between -1.1 to -5.8 mG, and a tentative methanol magnetic field strength of -18 mG is measured.Comment: 10 Pages, 5 Figure

Vitamin D in Australia : issues and recommendations

BACKGROUND A significant number of Australians and people from specific groups within the community are suffering from vitamin D deficiency. It is no longer acceptable to assume that all people in Australia receive adequate vitamin D from casual exposure to sunlight.OBJECTIVE This article provides information on causes, consequences, treatment and prevention of vitamin D deficiency in Australia. DISCUSSION People at high risk of vitamin D deficiency include the elderly, those with skin conditions where avoidance of sunlight is required, dark skinned people (particularly women during pregnancy or if veiled) and patients with malabsorption, eg. coeliac disease. For most people, deficiency can be prevented by 5&ndash;15 minutes exposure of face and upper limbs to sunlight 4&ndash;6 times per week. If this is not possible then a vitamin D supplement of at least 400 IU* per day is recommended. In cases of established vitamin D deficiency, supplementation with 3000-5000 IU per day for at least 1 month is required to replete body stores. Increased availability of larger dose preparations of cholecalciferol would be a useful therapy in the case of severe deficiencies. * 40 IU (international units) = 1 &micro;g<br /

Reconnection in a Weakly Stochastic Field

We examine the effect of weak, small scale magnetic field structure on the rate of reconnection in a strongly magnetized plasma. This affects the rate of reconnection by reducing the transverse scale for reconnection flows, and by allowing many independent flux reconnection events to occur simultaneously. Allowing only for the first effect and using Goldreich and Sridhar's model of strong turbulence in a magnetized plasma with negligible intermittency, we find that the lower limit for the reconnection speed is the Alfven speed times the Lundquist number to the power (-3/16). The upper limit on the reconnection speed is typically a large fraction of Alfven speed. We argue that generic reconnection in turbulent plasmas will normally occur at close to this upper limit. The fraction of magnetic energy that goes directly into electron heating scales as Lundquist number to the power (-2/5) and the thickness of the current sheet scales as the Lundquist number to the power (-3/5). A significant fraction of the magnetic energy goes into high frequency Alfven waves. We claim that the qualitative sense of these conclusions, that reconnection is fast even though current sheets are narrow, is almost independent of the local physics of reconnection and the nature of the turbulent cascade. As the consequence of this the Galactic and Solar dynamos are generically fast, i.e. do not depend on the plasma resistivity.Comment: Extended version accepted to ApJ, 44pages, 2 figure

The 43GHz SiO maser in the circumstellar envelope of the AGB star R Cassiopeiae

We present multi-epoch, total intensity, high-resolution images of 43GHz, v=1, J=1-0 SiO maser emission toward the Mira variable R Cas. In total we have 23 epochs of data for R Cas at approximate monthly intervals over an optical pulsation phase range from 0.158 to 1.78. These maps show a ring-like distribution of the maser features in a shell, which is assumed to be centred on the star at a radius of 1.6 to 2.3 times the stellar radii. It is clear from these images that the maser emission is significantly extended around the star. At some epochs a faint outer arc can be seen at 2.2 stellar radii. The intensity of the emission waxes and wanes during the stellar phase. Some maser features are seen infalling as well as outflowing. We have made initial comparisons of our data with models by Gray et. al. (2009).Comment: 12 pages, 14 figure

Host cell-intrinsic innate immune recognition of SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of 2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical investigations indicate that severe forms of COVID-19 are due in part to dysregulated immune responses to virus infection. The innate immune system is the first line of host defense against most virus infections, with pathogen recognition receptors detecting SARS-CoV-2 RNA and protein components and initiating pro-inflammatory and antiviral responses. Notwithstanding this response, SARS-CoV-2 proteins evade, inhibit, and skew innate immune signaling early in infection. In this review, we highlight the components of cell-based recognition of SARS-CoV-2 infection and the mechanisms employed by the virus to modulate these innate immune host defense pathways