THE IMPACT OF INCREASING ENROLLMENT ON FACULTY WORKLOAD AND STUDENT SATISFACTION OVER TIME

Detailed daily records of instructor effort in an established asynchronous online course over a three and one-half year period are analyzed. Student satisfaction data acquired from course evaluation surveys over the same period are also examined. In response to a three-fold increase in enrollment over the period, instructors realized a twelve percent gain in efficiency. Contrary to expectations, a modest economy of scale was achieved with no discernible decrease in student satisfaction

Longitudinal Trends in All Healthcare-Associated Infections through Comprehensive Hospital-wide Surveillance and Infection Control Measures over the Past 12 Years: Substantial Burden of Healthcare-Associated Infections Outside of Intensive Care Units and “Other” Types of Infection

OBJECTIVE Targeted surveillance has focused on device-associated infections and surgical site infections (SSIs) and is often limited to healthcare-associated infections (HAIs) in high-risk areas. Longitudinal trends in all HAIs, including other types of HAIs, and HAIs outside of intensive care units (ICUs) remain unclear. We examined the incidences of all HAIs using comprehensive hospital-wide surveillance over a 12-year period (2001–2012). METHODS This retrospective observational study was conducted at the University of North Carolina (UNC) Hospitals, a tertiary care academic facility. All HAIs, including 5 major infections with 14 specific infection sites as defined using CDC criteria, were ascertained through comprehensive hospital-wide surveillance. Generalized linear models were used to examine the incidence rate difference by infection type over time. RESULTS A total of 16,579 HAIs included 6,397 cases in ICUs and 10,182 cases outside ICUs. The incidence of overall HAIs decreased significantly hospital-wide (−3.4 infections per 1,000 patient days), in ICUs (−8.4 infections per 1,000 patient days), and in non-ICU settings (−1.9 infections per 1,000 patient days). The incidences of bloodstream infection, urinary tract infection, and pneumonia in hospital-wide settings decreased significantly, but the incidences of SSI and lower respiratory tract infection remained unchanged. The incidence of Clostridium difficile infection (CDI) increased remarkably. The outcomes were estimated to include 700 overall HAIs prevented, 40 lives saved, and cost savings in excess of $10 million. CONCLUSIONS We demonstrated success in reducing overall HAIs over a 12-year period. Our data underscore the necessity for surveillance and infection prevention interventions outside of the ICUs, for non–device-associated HAIs, and for CDI. Infect Control Hosp Epidemiol 2015;36(10):1139–114

The GIS Professional Ethics Project: Practical Ethics Education for GIS Professionals

Teaching GIS involves teaching ethical and moral thinking as a distinct engagement with the use, applications, and responsibilities of GIS professionals. Over the past 20 years scholars (particularly those affiliated with the discipline of Geography) have contributed critiques of the instrumental nature of GIS as well as reflective case studies that seek to demonstrate how the technology can be used to promote social justice. During the same period a profession of GIS developed as governmental and private use of GIS burgeoned; a marker for the professionalization of GIS in the United States can be found in the observation that by mid-2009 over 4,500 individuals had earned certification as GIS professionals. Requirements for professional certification in the U.S. include practitioners’ commitment to adhere with a formal Code of Ethics and Rules of Conduct. Meanwhile, U.S. higher education institutions have rushed to develop practice-oriented certificate and degree programs in response to the increasing demand for qualified GIS professionals in industry and government. Professional programs differ from academic degree programs in that most are designed to produce practitioners rather than scholars. In general, the rich literature in GIS and Society and Critical GIS is more useful to students and instructors in academic programs than those in professional programs. The objective of the National Science Foundation-funded GIS Professional Ethics Project (http://gisprofessionalethics.org) we describe in this chapter is to provide pedagogical practice and resources for American students and academics. The project combines the perspectives and experience of GIS educators and applied ethicists. The project has produced open educational resources (especially formal case studies with explicit linkages to the Code and Rules) to help professional GIS higher education programs prepare current and future practitioners to recognize and engage ethical problems.This is an author's manuscript, as accepted by the publisher. The published chapter [14] is copyrighted by John Wiley & Sons, Inc

The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish

Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses chromatin modifications on both the DNA and histones and is as important as the DNA sequence itself. Chromatin-modifying factors are playing an increasingly important role in tumorigenesis, particularly among pediatric rhabdomyosarcomas (RMS), revealing potential novel therapeutic targets. We performed an overexpression screen of chromatin-modifying factors in a KRASG12D-driven zebrafish model for RMS. Here, we describe the identification of a histone H3 lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal RMS formation in zebrafish. This suppression is specific to the histone methyltransferase activity of SUV39H1, as point mutations in the SET domain lacked the effect. SUV39H1-overexpressing and control tumors have a similar proliferation rate, muscle differentiation state, and tumor growth rate. Strikingly, SUV39H1-overexpressing fish initiate fewer tumors, which results in the observed suppressive phenotype. We demonstrate that the delayed tumor onset occurs between 5 and 7 days post fertilization. Gene expression profiling at these stages revealed that in the context of KRASG12D overexpression, SUV39H1 may suppress cell cycle progression. Our studies provide evidence for the role of SUV39H1 as a tumor suppressor

Reduction of Healthcare-Associated Infections by Exceeding High Compliance with Hand Hygiene Practices

Improving hand hygiene from high to very high compliance has not been documented to decrease healthcare-associated infections. We conducted longitudinal analyses during 2013–2015 in an 853-bed hospital and observed a significantly increased hand hygiene compliance rate (p<0.001) and a significantly decreased healthcare-associated infection rate (p = 0.0066)

THE GIS PROFESSIONAL ETHICS PROJECT: PRACTICAL ETHICS EDUCATION FOR GIS PROS

Abstract GIS professors and GIS professionals are separate but overlapping populations, in the U.S. at least. Both communities care about the moral and ethical implications of geospatial technologies and practices. They tend to express their concerns in different ways, however. Over the past 20 years scholars (particularly those affiliated with the discipline of Geography) have contributed critiques of the instrumental nature of GIS as well as reflective case studies that seek to demonstrate how the technology can be used to promote social justice. During the same period a profession of GIS coalesced; by mid-2009 over 4,500 individuals had earned certification as GIS Professionals. Requirements for professional certification in the U.S. include practitioners&apos; commitment to comply with a formal Code of Ethics and Rules of Conduct. Meanwhile, U.S. higher education institutions have rushed to develop practice-oriented certificate and degree programs in response to the increasing demand for qualified GIS professionals in industry and government. Professional programs differ from academic degree programs in that most are designed to produce practitioners rather than scholars. In general, the rich literature in GIS and Society and Critical GIS is more useful to students and instructors in academic programs than those in professional programs. The objective of the National Science Foundation-funded GIS Professional Ethics Project is to produce open educational resources (especially formal case studies with explicit linkages to the Code and Rules) that help professional programs prepare current and future practitioners to recognize ethical problems and to act with integrity. The project (http://gisprofessionalethics.org) combines the perspectives and experience of GIS educators and applied ethicists. The goal of this ICA paper is to promote widespread use of GIS-specific case studies and to invite international perspectives on applied ethics in the GIS profession

Invasive cutaneous rhizopus infections in an immunocompromised patient population associated with hospital laundry carts

Mucormycosis is an invasive fungal infection with high morbidity and mortality that most commonly occurs in immunocompromised hosts.1–5 Cutaneous mucormycosis is rare and can be acquired through direct contact of the fungi with non-intact skin or mucous membranes.3,4,7–9 Outbreaks of mucormycosis associated with contaminated adhesive bandages, ostomy supplies, wooden tongue depressors, and linen have been published.1,6–9 This is a report of a cluster of cutaneous mucormycosis with Rhizopus that occurred in 4 immunocompromised inpatients housed primarily in the same intensive care unit (ICU) prior to infection

Timeline of health care–associated infections and pathogens after burn injuries

Infections are an important cause of morbidity and mortality after burn injuries. Here, we describe the timeline of infections and pathogens after burns