Electromagnetic counterparts of high-frequency gravitational waves having additional polarization states: distinguishing and probing tensor-mode, vector-mode and scalar-mode gravitons

GWs from extra dimensions, very early universe, and some high-energy astrophysical process, might have at most six polarizations: plus- and cross-type (tensor-mode gravitons), x-, y-type (vector-mode), and b-, l-type (scalar-mode). Peak or partial peak regions of some of such GWs are just distributed in GHz or higher frequency band, which would be optimal band for electromagnetic(EM) response. In this paper we investigate EM response to such high-frequency GWs(HFGWs) having additional polarizations. For the first time we address:(1)concrete forms of analytic solutions for perturbed EM fields caused by HFGWs having all six possible polarizations in background stable EM fields; (2)perturbed EM signals of HFGWs with additional polarizations in three-dimensional-synchro-resonance-system(3DSR system) and in galactic-extragalactic background EM fields. These perturbative EM fields are actually EM counterparts of HFGWs, and such results provide a novel way to simultaneously distinguish and display all possible six polarizations. It is also shown: (i)In EM response, pure cross-, x-type and pure y-type polarizations can independently generate perturbative photon fluxes(PPFs, signals), while plus-, b- and l-type polarizations produce PPFs in different combination states. (ii) All such six polarizations have separability and detectability. (iii)In EM response to HFGWs from extra-dimensions, distinguishing and displaying different polarizations would be quite possible due to their very high frequencies, large energy densities and special properties of spectrum. (iv)Detection band(10^8 to 10^12 Hz or higher) of PPFs by 3DSR and observation range(7*10^7 to 3*10^9 Hz) of PPFs by FAST (Five-hundred-meter-Aperture-Spherical Telescope, China), have a certain overlapping property, so their coincidence experiments will have high complementarity.Comment: 27 pages, 16 figure

Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis

Background: Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the clinical variables would improve the prediction of mortality in sepsis. Methods: This retrospective study included 157 septic patients (112 patients with sepsis; 45 patients with septic shock). Procalcitonin (PCT), presepsin, galectin-3, and soluble suppression of tumorigenicity 2 (sST2) concentrations were analyzed in relation to the 30-day all-cause mortality. Their value added on top of Sequential (Sepsis-related) Organ Failure Assessment (SOFA) score, high-sensitivity C-reactive protein, and white blood cells was also analyzed. Results: PCT could not predict 30-day mortality. Univariate hazard ratio [HR with 95% confidence interval (CI)] of the other dichotomized variables was: 1.33 (0.55–3.194) for presepsin; 7.87 (2.29–26.96) for galectin-3; 1.55 (0.71–3.38) for sST2; and 2.18 (1.01–4.75) for SOFA score. The risk of 30-day mortality increased stepwise as the number of biomarkers above optimal cutoff values increased, and the highest risk was observed when all four biomarkers and SOFA score increased (HR = 14.5). Multi-marker approach predicted 30-day mortality better than SOFA score [area under the curves (95% CI), 0.769 (0.695–0.833) vs. 0.615 (0.535–0.692)]. In reclassification analyses, adding biomarkers to clinical variables improved the prediction of mortality. Conclusion: This study demonstrated a possible prognostic utility of PCT, presepsin, galectin-3, and sST2 in sepsis. Multi-marker approach could be beneficial for an optimized management of patients with sepsis

4,4′-Azinodibenzoic acid

The title compound, C14H10N2O4, shows crystallographic inversion symmetry and has one half-mol­ecule in the asymmetric unit. In the crystal, mol­ecules are linked into chains running along the cell diagonal by O—H⋯O hydrogen-bonding inter­actions

A Study on Trust of E-commerce Market Based on Multi-agents Model

The process of the trust production and transfer is both stochastic and rational. In this article, we analyze the characters of this process in consumer’s social networks, by dividing consumers and merchants into two types: Risk-aversion type and Risk-neutral type for consumers, high-grade and low-grade for merchants respectively. Based on multi-agent NETLogo system, three kinds of virtual social networks are constructed, which are the risk-neutral without institution, risk-aversion without institution, risk-aversion but with good institution. The rules of the production and transfer of trust in consumer-to-consumer and merchant-to-consumers are defined. Based on a series of computational experiments and statistical comparison, we draw a conclusion that the characters of consumers do not change the trend of e-business market scale, but only change the equilibrium value. On the other hand, a risk-aversion with good institutional society can boost market to have a highly upward trend and be self-stable. Consequentially, this article indirectly proved of the essentials for establishing the institution-based trust

HIF-1α Contributes to Hypoxia-induced Invasion and Metastasis of Esophageal Carcinoma via Inhibiting E-cadherin and Promoting MMP-2 Expression

Hypoxia-inducible factor-1α (HIF-1α) has been found to enhance tumor invasion and metastasis, but no study has reported its action in esophageal carcinoma. The goal of this study was to explore the probable mechanism of HIF-1α in the invasion and metastasis of esophageal carcinoma Eca109 cells in vitro and in vivo. mRNA and protein expression of HIF-1α, E-cadherin and matrix metalloproteinase-2 (MMP-2) under hypoxia were detected by RT-PCR and Western blotting. The effects of silencing HIF-1α on E-cadherin, MMP-2 mRNA and protein expression under hypoxia or normoxia were detected by RT-PCR and Western blotting, respectively. The invasive ability of Eca109 cells was tested using a transwell chambers. We established an Eca109-implanted tumor model and observed tumor growth and lymph node metastasis. The expression of HIF-1α, E-cadherin and MMP-2 in xenograft tumors was detected by Western blotting. After exposure to hypoxia, HIF-1α protein was up-regulated, both mRNA and protein levels of E-cadherin were down-regulated and MMP-2 was up-regulated, while HIF-1α mRNA showed no significant change. SiRNA could block HIF-1α effectively, increase E-cadherin expression and inhibit MMP-2 expression. The number of invading cells decreased after HIF-1α was silenced. Meanwhile, the tumor volume was much smaller, and the metastatic rate of lymph nodes and the positive rate were lower in vivo. Our observations suggest that HIF-1α inhibition might be an effective strategy to weaken invasion and metastasis in the esophageal carcinoma Eca109 cell line