Occurrence of Porphyromonas gingivalis, Bacteroides forsythus, and Treponema denticola in Periodontally Healthy and Diseased Subjects as Determined by an ELISA Technique

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142036/1/jper0018.pd

In Vivo and In Vitro Accuracy Analysis of Static Computer-Assisted Implant Surgery in an Edentulous Patient

Background: Recently, intraoral scanning (IOS) has been proposed as a new tool to evaluate the accuracy of static computer-assisted implant surgery (s-CAIS); however, further research is needed to improve the precision of IOS for full-arch impressions. The purpose of the study was to assess the accuracy of s-CAIS in an edentulous patient either in vivo or in vitro with two different evaluation techniques and to investigate if their results are comparable. Methods: A patient with terminal dentition was selected and four implants were placed using s-CAIS with a bone-supported stackable template. Segmentation used for designing a template was 3D printed, and then four implants were placed in the model following the same protocol as for s-CAIS. The model then underwent cone beam computed tomography (CBCT) and laboratory scanning to evaluate its accuracy. Data were uploaded to specific software, and accuracy values were automatically generated. Results: A statistical analysis was not attempted since all measurements were performed on the same patient and model. When descriptively comparing the accuracy of the two methods of treatment evaluation in the in vitro scenario, comparable results were obtained between IOS and CBCT, except for the angle. Conclusions: As the intraoral scanning procedure in fully edentulous patients is not yet clinically validated, utilizing CBCT can still be recommended for the accurate evaluation of computer-assisted implant placement

Could early rheumatoid arthritis resolve after periodontitis treatment only?

Rheumatoid arthritis (RA) is an immune-mediated polyarthritis; currently no pathogenic agent has been identified as a disease trigger. A patient with RA, presumably caused by periodontal infection, whose remission has been observed after periodontitis treatment in absence of specific RA therapy, is reported here for the first time, to our knowledge. A 61-year-old male patient presented migrant arthritis associated with antibodies against citrullinated protein antigens positivity. The clinical features allowed to make RA diagnosis according to the 2010 European League against Rheumatism/American College of Rheumatology RA classification criteria. X-ray of the second upper molar showed chronic apical periodontitis. After its treatment, arthritis remission has been observed in the absence of specific RA therapy. It has been suggested that periodontitis may have a trigger role in RA pathogenesis. This could be explained by the enzymatic action of Porphyromonas gingivalis, probably leading to break tolerance to collagen. The identification and subsequent treatment of periodontitis should therefore be considered pivotal in RA prophylaxis and management

N-3 fatty acids in patients with multiple cardiovascular risk factors

BACKGROUND: Trials have shown a beneficial effect of n-3 polyunsaturated fatty acids in patients with a previous myocardial infarction or heart failure. We evaluated the potential benefit of such therapy in patients with multiple cardiovascular risk factors or atherosclerotic vascular disease who had not had a myocardial infarction. METHODS: In this double-blind, placebo-controlled clinical trial, we enrolled a cohort of patients who were followed by a network of 860 general practitioners in Italy. Eligible patients were men and women with multiple cardiovascular risk factors or atherosclerotic vascular disease but not myocardial infarction. Patients were randomly assigned to n-3 fatty acids (1 g daily) or placebo (olive oil). The initially specified primary end point was the cumulative rate of death, nonfatal myocardial infarction, and nonfatal stroke. At 1 year, after the event rate was found to be lower than anticipated, the primary end point was revised as time to death from cardiovascular causes or admission to the hospital for cardiovascular causes. RESULTS: Of the 12,513 patients enrolled, 6244 were randomly assigned to n-3 fatty acids and 6269 to placebo. With a median of 5 years of follow-up, the primary end point occurred in 1478 of 12,505 patients included in the analysis (11.8%), of whom 733 of 6239 (11.7%) had received n-3 fatty acids and 745 of 6266 (11.9%) had received placebo (adjusted hazard ratio with n-3 fatty acids, 0.97; 95% confidence interval, 0.88 to 1.08; P=0.58). The same null results were observed for all the secondary end points. CONCLUSIONS: In a large general-practice cohort of patients with multiple cardiovascular risk factors, daily treatment with n-3 fatty acids did not reduce cardiovascular mortality and morbidity. Copyright © 2013 Massachusetts Medical Society