Electric field effects on the dynamics of bubble detachment from an inclined surface

An experimental apparatus to study bubble detachment from an inclined surface under the action of electric forces is described. It consists of a container filled with FC72 at room temperature and pressure where a train of gas bubbles is injected from an orifice. An electrostatic field can be imposed around the bubble, while the cell can be tilted from 0 to 90°. It is possible to study interface growth with the aid of high-speed cinematography. Since the interface is asymmetrical, a mirror system allowed to acquire, in the same frame, two images at 90° of the bubble. Different inclinations, injection rates and voltages were tested in order to couple the effects of shear gravity and electric field. Curvature and contact angles have been derived with appropriate interpolation methods of the profile. Force balances on the bubble were checked, finding an electric force, which, at first pulls the bubbles from the orifice, then pushes it against the surface. The motion of the center of gravity confirms this behaviour. A power balance has been developed to determine the energy contributions, revealing that surface growth incorporates both the effects of inlet power and electric field

Modulation of STAT3 signaling, cell redox defenses and cell cycle checkpoints by β-caryophyllene in cholangiocarcinoma cells: possible mechanisms accounting for doxorubicin chemosensitization and chemoprevention

Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes. In the attempt to identify new therapeutic strategies for CCA, we studied the antiproliferative activity of a combination between doxorubicin and the natural sesquiterpene β-caryophyllene in cholangiocarcinoma Mz-ChA-1 cells and nonmalignant H69 cholangiocytes, under both long-term and metronomic schedules. The modulation of STAT3 signaling, oxidative stress, DNA damage response, cell cycle progression and apoptosis was investigated as possible mechanisms of action. β-caryophyllene was able to synergize the cytotoxicity of low dose doxorubicin in Mz-ChA-1 cells, while producing cytoprotective effects in H69 cholangiocytes, mainly after a long-term exposure of 24 h. The mechanistic analysis highlighted that the sesquiterpene induced a cell cycle arrest in G2/M phase along with the doxorubicin-induced accumulation in S phase, reduced the γH2AX and GSH levels without affecting GSSG. ROS amount was partly lowered by the combination in Mz-ChA-1 cells, while increased in H69 cells. A lowered expression of doxorubicin-induced STAT3 activation was found in the presence of β-caryophyllene in both cancer and normal cholangiocytes. These networking effects resulted in an increased apoptosis rate in Mz-ChA-1 cells, despite a lowering in H69 cholangiocytes. This evidence highlighted a possible role of STAT3 as a final effector of a complex network regulated by β-caryophyllene, which leads to an enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and a lowered chemotherapy toxicity in nonmalignant cholangiocytes, thus strengthening the interest for this natural sesquiterpene as a dual-acting chemosensitizing and chemopreventive agent

Resurgence and 1/N Expansion in Integrable Field Theories

In theories with renormalons the perturbative series is factorially divergent even after restricting to a given order in 1/N, making the 1/N expansion a natural testing ground for the theory of resurgence. We study in detail the interplay between resurgent properties and the 1/N expansion in various integrable field theories with renormalons. We focus on the free energy in the presence of a chemical potential coupled to a conserved charge, which can be computed exactly with the thermodynamic Bethe ansatz (TBA). In some examples, like the first 1/N correction to the free energy in the non-linear sigma model, the terms in the 1/N expansion can be fully decoded in terms of a resurgent trans-series in the coupling constant. In the principal chiral field we find a new, explicit solution for the large N free energy which can be written as the median resummation of a trans-series with infinitely many, analytically computable IR renormalon corrections. However, in other examples, like the Gross-Neveu model, each term in the 1/N expansion includes non-perturbative corrections which can not be predicted by a resurgent analysis of the corresponding perturbative series. We also study the properties of the series in 1/N. In the Gross-Neveu model, where this is convergent, we analytically continue the series beyond its radius of convergence and show how the continuation matches with known dualities with sine-Gordon theories

Beyond Income and Inequlity: The Role of Socio-Political Factors for Alleviating Energy Poverty in Europe

In each country, the occurrence of energy poverty among resident households is usually related to low income and its unequal distribution. Like other manifestations of material deprivation, however, such a phenomenon is likely to be also correlated with some internal socio-political factors that allow its persistence by preventing effective solutions. In this paper, we build and analyse a dataset for European countries by assessing the role of the perceived quality of internal public governance on different measures of energy deprivation. Specifically, we rely on the Worldwide Governance Indicators provided by the World Bank and estimate an array of panel models. After controlling for income, income inequality, energy prices, and weather conditions, we find that high government effectiveness, good regulatory quality, widespread property rights, contract enforcement, and corruption control are significantly associated with lower energy poverty. In addition, we consider the policy implications of this broader perspective on energy deprivation

A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11

Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes. Haploidization is achieved via two successive rounds of chromosome segregation, meiosis I and II. In mammals, during prophase of meiosis I, homologous chromosomes align and synapse through a recombination-mediated mechanism initiated by the introduction of DNA double-strand breaks (DSBs) by the SPO11 protein. In male mice, if SPO11 expression and DSB number are reduced below heterozygosity levels, chromosome synapsis is delayed, chromosome tangles form at pachynema, and defective cells are eliminated by apoptosis at epithelial stage IV at a spermatogenesis-specific endpoint. Whether DSB levels produced in Spo11 +/− spermatocytes represent, or approximate, the threshold level required to guarantee successful homologous chromosome pairing is unknown. Using a mouse model that expresses Spo11 from a bacterial artificial chromosome, within a Spo11 −/− background, we demonstrate that when SPO11 expression is reduced and DSBs at zygonema are decreased (approximately 40 % below wild-type level), meiotic chromosome pairing is normal. Conversely, DMC1 foci number is increased at pachynema, suggesting that under these experimental conditions, DSBs are likely made with delayed kinetics at zygonema. In addition, we provide evidences that when zygotene-like cells receive enough DSBs before chromosome tangles develop, chromosome synapsis can be completed in most cells, preventing their apoptotic elimination

Cation-Responsive and Photocleavable Hydrogels from Noncanonical Amphiphilic DNA Nanostructures.

Funder: Imperial College LondonThanks to its biocompatibility, versatility, and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering, and drug delivery. Of particular importance for in vivo applications is the possibility of making such nanomaterials responsive to physiological stimuli. Here, we demonstrate how combining noncanonical DNA G-quadruplex (G4) structures with amphiphilic DNA constructs yields nanostructures, which we termed "Quad-Stars", capable of assembling into responsive hydrogel particles via a straightforward, enzyme-free, one-pot reaction. The embedded G4 structures allow one to trigger and control the assembly/disassembly in a reversible fashion by adding or removing K+ ions. Furthermore, the hydrogel aggregates can be photo-disassembled upon near-UV irradiation in the presence of a porphyrin photosensitizer. The combined reversibility of assembly, responsiveness, and cargo-loading capabilities of the hydrophobic moieties make Quad-Stars a promising candidate for biosensors and responsive drug delivery carriers

Stampa di tavolette tattili per il Festival di Astronomia di Castellaro Lagusello

L’astronomia è uno dei campi del sapere che più affascina e attrae tutte le persone: chiunque può interrogarsi su come si è formato l’Universo, o cosa accadrà quando si spegnerà il Sole, o se esiste vita su altri pianeti. E tutti dovrebbero avere l’opportunità di conoscere le risposte a queste domande, almeno per quanto gli scienziati hanno scoperto finora. Per questa ragione l’Istituto Nazionale di Astrofisica sta perseguendo, da vari anni, strategie per rendere i suoi materiali didattici idonei anche a un pubblico di persone ipovedenti o non vedenti. Le risorse tipicamente disponibili per presentare concetti astronomici a persone con difficoltà visive sono limitate a figure tridimensionali, figure piane tattili e alcune lezioni in Braille. Alcune istituzioni accademiche, luoghi pubblici e musei hanno una selezione limitata di materiali adatti che possono essere utilizzati per elaborare concetti di astronomia e sono disponibili per l'uso da parte di visitatori e studenti ipovedenti. Imparare a presentare i concetti di astronomia secondo le esigenze individuali in questo modo non solo migliora l'apprezzamento individuale dei concetti e l'accesso alla conoscenza scientifica, ma promuove anche una cultura del rispetto per le differenze degli altri. Questo documento si pone come obiettivo quello di raccogliere e descrivere le prime esperienze di stampa 3D con la stampante Stratasys j55 volte e realizzare una serie di modelli tattili di galassie e costellazioni che saranno utilizzati durante la terza edizione del Festival di Astronomia di Castellaro Lagusello

Evaluating Machine-Learning Techniques for Detecting Smart Ponzi Schemes

International audienceEthereum is one of the most popular platforms for exchanging cryptocurrencies as well as the most established for peer to peer programming and smart contracts publishing [3]. The versatility of the Solidity language allows developers to program general-purpose smart contracts. Among the various smart contracts, there may be some fraudulent ones, whose purpose is to steal Ether from the network participants. A notorious example of such cases are Ponzi schemes, i.e. a financial frauds that require investors to be repaid through the investments of others who have just entered the scheme. Within the Ethereum blockchain, several contracts have been identified as being Ponzi schemes. The paper proposes a machine learning model that uses textual classification techniques to recognize contracts emulating the behavior of a Ponzi scheme. Starting from a contracts dataset containing exclusively Ponzi schemes uploaded between 2016 and 2018, we built models able to properly classify Ponzi schemes contracts. We tested several models, some of which returned an overall accuracy of 99% on classification. The best model turned out to be the linear Support Vector Machine and the Multinomial Naive Bayes model, which provides the best results in terms of metrics evaluation