4 research outputs found
Homocysteine levels and the risk of osteoporotic fracture
BACKGROUND: Very high plasma homocysteine levels are characteristic of
homocystinuria, a rare autosomal recessive disease accompanied by the
early onset of generalized osteoporosis. We therefore hypothesized that
mildly elevated homocysteine levels might be related to age-related
osteoporotic fractures. METHODS: We studied the association between
circulating homocysteine levels and the risk of incident osteoporotic
fracture in 2406 subjects, 55 years of age or older, who participated in
two separate prospective, population-based studies. In the Rotterdam
Study, there were two independent cohorts: 562 subjects in cohort 1, with
a mean follow-up period of 8.1 years; and 553 subjects in cohort 2, with a
mean follow-up period of 5.7 years. In the Longitudinal Aging Study
Amsterdam, there was a single cohort of 1291 subjects, with a mean
follow-up period of 2.7 years. Multivariate Cox proportional-hazards
regression mode