Formulation and in-vitro evaluation of theophylline sustained release tablet

The aim of present study was to prepare sustained release tablet of Theophylline so as to prolong its elimination time and at the same time to keep cost of the formulation minimum. In this study ethyl cellulose and Eudragit are used in the formulation to sustain the release of Theophylline. Ethyl cellulose and Eudragit are added at the granulation step to form a sustained release coating around each granule. Different batches were designed one after another on trial and error basis to get the optimum drug release upto 12 hours. Keywords: Theophylline, ethyl cellulose, Eudragit, sustained release, coating, tablet

Estimation of Labetalol Hydrochloride in bulk and formulation by UV-Spectrophotometric Area Under Curve.

The current work was carried out for estimation of labetalol hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve method (AUC) method .For this purpose the wavelength range 200-400 nm was selected .Distilled Water was used as a solvent throughout the work. The linearity was observed in concentration range 5-25 µg/ml (r2 =0.9788) for the method. The present was found which can be used for routine quality control analysis for spectrophotometric estimation of labetalol hydrochloride in bulk and dosage form. Keywords: Labetalol hydrochloride, Area under curve (AUC), Distilled Water, UV Spectrophotometric

Estimation of Nortriptyline hydrochloride in Bulk and Formulation by UV-Spectrophotometric Area Under Curve Method

The simple, precise and accurate UV-Spectrophotometric method has been developed and validated for the estimation of nortriptyline hydrochloride in bulk and dosage form. In that work was carried out for estimation of nortriptyline hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve (AUC) method. For this purpose the wavelength range 200-400nm was selected. DMSO was used as solvent throughout the work. Linearity was observed in concentration range 5-25µg/ml (R2 =0.996) for the method. The present method was found which can be used for routine quality control analysis for spectrophotometric estimation of Nortriptyline hydrochloride in bulk and dosage form. Keywords: Nortriptyline hydrochloride, Area under curve (AUC), DMSO, UV-Spectrophotometric

Extraction, Characterization and Evaluation of Okara Mucilage

Mucilage is the thick, gluey substances produced by nearly all plant and some microorganisms. Okra mucilage is extracted from the plant of the malavaceae [A. esculantus]. Which is originally from Egypt, but it also in cropped in southern Asia elsewhere for nutritional purposes. Their use as potential reinforcement in polymer composites requires the understanding of their microstructure and mechanical properties. This work investigates the extraction methods, solubility behavior, TLC, loss on drying, ash value, FTIR spectra, surface tension, organoleptic properties. Extracted mucilage is soluble in warm water while insoluble in organic solvents. This can shows that it safely used in dosage form without causing any adverse effect. Keywords: Okara Mucilage, Pharmaceutical Excipients, Controlled-Release Formulatio

The Enhancement of solubility and dissolution rate of saxagliptine hydrochloride by solid dispersion technique

Saxagliptine hydrochloride, PEG, polaxamer-407,ethyl cellulose were prepared to study the dissolution of sparingly water soluble Saxagliptine hydrochloride drug. solid dispersion of Saxagliptine hydrochloride were prepared using different ratios of PEG 6000 & Polaxamer-407.Some of the practical aspects to be considered for the preparation of solid dispersion such as selection of polymers ,methods of preparation solubility of drug and dissolution study of drug in solid dispersion are also discussed. The present research provides a there is increase in solubility of Saxagliptine hydrochloride and also solid dispersion complex of drug was giving better  dissolution profile as compared to other solid dispersions this imporove bioavailability. FT-IR , shows the compatability of drug & carrier. Keywords- solid dispersion, solubility enhancement, dissolution rat