Role of sintering temperature dependent crystallization of bioactive glasses on erythrocyte and cytocompatibility

Bioglass (BG) was prepared by sol-gel method and the role of sintering temperatures (600, 700 and 800 °C) on crystalline phase changes, bioactivity, erythrocyte and MG-63 cell line compatibility was investigated. Increase in sintering temperature from 600 to 800 °C led to the secondary phase formation that was confirmed through structural analysis. Micrographics revealed the formation of nanorods (700 °C) and nanoflake like (800 °C) morphologies. Biocompatibility assay showed that, BG sintered at 600 °C had optimal biocompatibility while better mechanical property was noted at 700 °C. Altogether, the study demonstrated that increasing the sintering temperature will result in increased crystallinity which in turn resulted in the optimal biomineralization but decreased the biocompatibility. Hence, we demonstrated the importance of temperature during the processing of BG for various applications, as it affects many properties including bioactivity and compatibility

A Review of Electroactive Nanomaterials in the Detection of Nitrogen-Containing Organic Compounds and Future Applications

Electrochemical and impedimetric detection of nitrogen-containing organic compounds (NOCs) in blood, urine, sweat, and saliva is widely used in clinical diagnosis. NOC detection is used to identify illnesses such as chronic kidney disease (CKD), end-stage renal disease (ESRD), cardiovascular complications, diabetes, cancer, and others. In recent years, nanomaterials have shown significant potential in the detection of NOCs using electrochemical and impedimetric sensors. This potential is due to the higher surface area, porous nature, and functional groups of nanomaterials, which can aid in improving the sensing performance with inexpensive, direct, and quick-time processing methods. In this review, we discuss nanomaterials, such as metal oxides, graphene nanostructures, and their nanocomposites, for the detection of NOCs. Notably, researchers have considered nanocomposite-based devices, such as a field effect transistor (FET) and printed electrodes, for the detection of NOCs. In this review, we emphasize the significant importance of electrochemical and impedimetric methods in the detection of NOCs, which typically show higher sensitivity and selectivity. So, these methods will open a new way to make embeddable electrodes for point-of-detection (POD) devices. These devices could be used in the next generation of non-invasive analysis for biomedical and clinical applications. This review also summarizes recent state-of-the-art technology for the development of sensors for on-site monitoring and disease diagnosis at an earlier stage