Nevus sebaceus of Jadassohn: an unusual case report with review of literature

A 16-year-old girl presented with a new, rapidly growing, raised, hypopigmented, cerebriform plaque on the scalp. The skin lesion was brown coloured and with a waxy aspect. The diagnosis 'nevus sebaceus' was established. Nevus sebaceous of Jadassohn is a hamartoma with a combination of abnormalities of the epidermis, hair follicles, and sebaceous and apocrine glands. Herein, we report a case along with detailed review of literature of this unusual disease

γδ T-cell lymphoma: a rare entity mimicking hemophagocytic syndrome-report of two cases

γδ T-cell lymphoma is a rare extranodal and systemic neoplasm which accounts for less than 1% of all NHL having peak incidence in adolescents and young adults with a male predominance. Study report two cases, 29 and 25 years male presented with fever, abdominal pain and pancytopenia; one had hepatosplenomegaly while other had marked splenomegaly respectively and both showing feature of hemophagocytosis. Both underwent splenectomy. On gross examination, the spleen was markedly enlarged and shows a deep brown cut-surface. Histologically the normal structure of the spleen is totally effaced by a monotonous lymphoid population consisting of medium-large sized lymphoid cells with vesicular chromatin and small eosinophilic nucleolus with tumor cells showing moderate amount of eosinophilic cytoplasm. Liver biopsy showed regenerative changes in parenchyma and sinusoidal involvement by tumour cells. Peripheral smear revealed atypical lymphocytes with pancytopenia. Bone marrow aspiration showed moderate neoplastic infiltrate by lymphoid cells. Immunophenotypic study showed tumour cells expressing CD3, CD56, CD 2 (dim), TIA-1, TCR-gamma. The tumour cells were immunonegative for CD20, CD5, CD4, CD8, granzyme B, CD7, CD10 and CD 23. Immunophenotypic study is must for diagnosis of   γδ T-cell lymphoma which can mimic hemophagocytic syndrome

Role of semen analysis in the diagnosis of infertility at a tertiary care centre in Western India: a prospective study

Background: The prevalence of infertility in the general population is 15%-20%. Of this, the male factor is responsible for 20%-40%. In Indian couples seeking treatment, the male factor is the cause in approximately 23%. Semen analysis is an indispensable diagnostic tool in the evaluation of the male partners of infertile couples. Careful evaluation of the ejaculate parameters may suggest the possible causes of infertility and their identification could help to institute appropriate therapy, if available.Methods: Semen samples were analyzed by manual method. An analysis for volume, viscosity, sperm concentration, motility, and morphology, according to WHO guidelines on semen analysis was done.Results: This study, done at a tertiary care center at Western India, at M.G.M hospital has demonstrated that abnormal semen quality is a major factor contributing to infertility in couples.28% males had volume <2 ml, 70% had sperm count <20 million/ml and 72% had sperms with abnormal morphology.Conclusions: Semen analysis remains a significant contribution in the overall diagnosis of infertility in our environment and semen analysis is an indispensable diagnostic tool in the evaluation of the male partners of infertile couples. Males contribute towards infertility in couples significantly and further study and assessment is required to accurately predict the importance of this

OSPE as a Method of Learning and Assessment for Undergraduate Practical Pathology versus Traditional Learning and Assessment

Introduction: Objective Structured Practical Examination (OSPE) is an effective method for formative and summative assessment of undergraduate students during practical examination. Aim: The aim of the study was to study the effectiveness of OSPE in the subject of Pathology and to evaluate them on the basis of these parameters, provide feedback on performance, evaluate on basis of practical skills and measure minimal competences. Materials and methods: This study was conducted among a total of 120 M.B.B.S. students during their second year of MBBS course. OSPE based practical examination was carried out followed by a close ended questionnaire to evaluate student’s perception regarding the same. Results: OSPE was seen as a useful exercise by 83 % of the students. Feedback from the undergraduate students put forward that 17 % students felt that OSPE was an objective tool in evaluating practical skills. Conclusion: OSPE is a more valid and beneficial learning tool according to the students as well as faculty. Keywords: Objective structured practical examination, Pathology, Medical education, Teaching too

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era

Nevus sebaceus of Jadassohn: an unusual case report with review of literature

A 16-year-old girl presented with a new, rapidly growing, raised, hypopigmented, cerebriform plaque on the scalp. The skin lesion was brown coloured and with a waxy aspect. The diagnosis nevus sebaceus was established. Nevus sebaceous of Jadassohn is a hamartoma with a combination of abnormalities of the epidermis, hair follicles, and sebaceous and apocrine glands. Herein, we report a case along with detailed review of literature of this unusual disease. [Int J Res Med Sci 2016; 4(5.000): 1772-1774