In vitro synergism between estrogens and cytotoxic agents

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Effect of an homo-aza-steroidal ester on estrogen receptor

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

In vitro testing of cytotoxic compounds in hormone-dependent and -independent breast cancer cell lines

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Effect of CB 154 (2-Br-α-Ergocryptine) on MXT mammary tumor growth

This work analyses the effect of the potent prolactin secretion inhibitor 2 Br-alpha-ergocryptine (CB 154) on both the acceptance and the growth of the mouse transplantable MXT ovarian-dependent mammary tumor. CB 154 was injected at doses of 25 mg/kg and 50 mg/kg subcutaneously for 10 weeks. This treatment did not decrease the tumor acceptance but delayed the appearance of palpable tumor nodules. Furthermore estimation of the change in tumor surface area (TS) expressed in sq mm revealed that the drug reduced tumor growth. This effect became significant after 8 weeks. Tumor death was also significantly delayed (7 surviving mice in controls versus 13 in the 25 mg/kg group, and 12 in the 50 mg/kg group). The present data suggest that the MXT mouse mammary tumor is sensitive to prolactin. This property associated with the known ovarian hormone sensitivity makes this tumor a valuable experimental model for assessing hormone dependence of mammary carcinomas.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Estrogen-induced protein in the human breast cancer cell line MCF7

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Absence of antitumor activity of ORG 5895, a 11 β-aziridinylmethyl derivative of estradiol, on the MXT mammary tumor and the P388 leukemia

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Guide-lines in the design of new antiestrogens and cytotoxic-linked estrogens for the treatment of breast cancer

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Antagonism of cyclofenil and nafoxidine in the growth of the human breast cancer cell line MCF-7

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Tritiated actinomycin-D staining method: A valuable tool to study oestrogen receptor-induced modifications of transcriptional activity in normal and neoplastic cells

SCOPUS: ar.jinfo:eu-repo/semantics/publishe