REVIEW ON OCULAR INSERT DRUG DELIVERY SYSTEM

An ocular insert represents an advanced technology in eye disease therapy. Designing and development of an ocular insert is a challenge ever faced by Pharmaceutical researchers or manufacturer. In the ophthalmology; eye drop have ever found to be an easy remedy from the administration point of view. In case of conventional dosage forms the fast precorneal loss of drug has been a major difficulty. To improve ocular drug bioavailability, there are significant guidelines have been directed towards newer drug delivery systems for ophthalmic administration. By means of ocular insert, the researcher has always taken efforts to release the drug at controlled rate to avoid frequent administration of drug. The ocular insert consist of controlled, delayed or sustained release biodegradable implantable components of different material in multiple layers. The inserts can be classified in various classes like Insoluble, soluble or biodegradable as per its solubility. The release of drug from the insert depends upon the diffusion, osmosis, and bioerosion of the drug. Keyword: Ocular inserts, bioerosion, osmosis, bioerodible implant

In-Vitro Anti-Fungal Activity and Phytochemical Screening of Stem Bark Extracts from Ventilago denticulata

The objective of the present study was to assess the antifungal activity of pet. Ether extract, acetone extract, ethyl acetate, and ethanol bark extract of Ventilago denticulata (VD).The material was dried in shade made to a coarse powder and weighted quantity of the powder   (1000 g) was subjected to hot percolation in a soxhlet apparatus using petroleum ether, ethyl acetate, acetone and ethanol, at a temperature range of 40-800C. Phytochemical tests were done in presence of phytoconstituents like glycosides, alkaloids, tannins, steroids, flavonoids. The anti-fungal activity was carried out by using cup method using Sabraud’s agar as medium. Plates were incubated at 250C for 42hr and later observed for zones of inhibition. The effect of the extracts on fungal isolates was compared with Griseofluvin at a concentration of 10 mg/ml. The Ethyl acetate extract at low as well as high doses gives antifungal effect. Pet-ether extract, acetone extract and ethanolic extract did not produce any antifungal effect at both doses. Ethyl acetate extract shows zone of inhibition at low dose (T1 10 mg/ml) 10 mm and at high dose (T2  20 mg/ml) 16 mm. Keyword: Ventilago denticulata, Anti- fungal, Griseofluvin