Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials

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Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials

Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be suitable. We describe our experience of engaging patient advisors to identify an optimal model of consent for the PREP-IT trials. This paper also examines surrogate measures of success for the selected model of consent. Methods: The PREP-IT program consists of two multi-center cluster randomized crossover trials that engaged patient advisors to determine an optimal model of consent. Patient advisors and stakeholders met regularly and reached consensus on decisions related to the trial design including the model for consent. Patient advisors provided valuable insight on how key decisions on trial design and conduct would be received by participants and the impact these decisions will have. Results: Patient advisors, together with stakeholders, reviewed the pros and cons and the requirements for the traditional model of consent, deferred consent, and waiver of consent. Collectively, they agreed upon a deferred consent model, in which patients may be approached for consent after their fracture surgery and prior to data collection. The consent rate in PREP-IT is 80.7%, and 0.67% of participants have withdrawn consent for participation. Discussion: Involvement of patient advisors in the development of an optimal model of consent has been successful. Engagement of patient advisors is recommended for other large trials where the traditional model of consent may not be optimal

Measurement of the impact-parameter dependent azimuthal anisotropy in coherent ρ0 photoproduction in Pb–Pb collisions at √sNN = 5.02 TeV

The first measurement of the impact-parameter dependent angular anisotropy in the decay of coherently photoproduced ρ0 mesons is presented. The ρ0 mesons are reconstructed through their decay into a pion pair. The measured anisotropy corresponds to the amplitude of the cos(2ϕ) modulation, where ϕ is the angle between the two vectors formed by the sum and the difference of the transverse momenta of the pions, respectively. The measurement was performed by the ALICE Collaboration at the LHC using data from ultraperipheral Pb−Pb collisions at a center-of-mass energy of sNN−−−√ = 5.02 TeV per nucleon pair. Different impact-parameter regions are selected by classifying the events in nuclear-breakup classes. The amplitude of the cos(2ϕ) modulation is found to increase by about one order of magnitude from large to small impact parameters. Theoretical calculations, which describe the measurement, explain the cos(2ϕ) anisotropy as the result of a quantum interference effect at the femtometer scale that arises from the ambiguity as to which of the nuclei is the source of the photon in the interaction

Investigating strangeness enhancement in jet and medium via ϕ\phi(1020) production in p−-Pb collisions at sNN\sqrt{s_{\rm NN}} = 5.02 TeV

International audienceThis work aims to differentiate strangeness produced from hard processes (jet-like) and softer processes (underlying event) by measuring the angular correlation between a high-momentum trigger hadron (h) acting as a jet-proxy and a produced strange hadron ($\phi(1020)$ meson). Measuring h$-\phi$ correlations at midrapidity in p$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV as a function of event multiplicity provides insight into the microscopic origin of strangeness enhancement in small collision systems. The jet-like and the underlying-event-like strangeness production are investigated as a function of event multiplicity. They are also compared between a lower and higher momentum region. The evolution of the per-trigger yields within the near-side (aligned with the trigger hadron) and away-side (in the opposite direction of the trigger hadron) jet is studied separately, allowing for the characterization of two distinct jet-like production regimes. Furthermore, the h$-\phi$ correlations within the underlying event give access to a production regime dominated by soft production processes, which can be compared directly to the in-jet production. Comparisons between h$-\phi$ and dihadron correlations show that the observed strangeness enhancement is largely driven by the underlying event, where the $\phi/\mathrm{h}$ ratio is significantly larger than within the jet regions. As multiplicity increases, the fraction of the total $\phi(1020)$ yield coming from jets decreases compared to the underlying event production, leading to high-multiplicity events being dominated by the increased strangeness production from the underlying event

Measurement of Λ3H{}_{\Lambda}^{3}\mathrm{H} production in Pb-Pb collisions at sNN\sqrt{s_{\mathrm{NN}}} = 5.02 TeV

International audienceThe first measurement of $_{\Lambda}^{3}\mathrm{H}$ and $^3_ {\overline{\Lambda}}\overline{\mathrm{H}}$ differential production with respect to transverse momentum and centrality in Pb$-$Pb collisions at $\sqrt{s_{\mathrm{NN}}}=5.02$~TeV is presented. The $_{\Lambda}^{3}\mathrm{H}$ has been reconstructed via its two-charged-body decay channel, i.e., $_{\Lambda}^{3}\mathrm{H} \rightarrow {}^{3}\mathrm{He} + \pi^{-}$. A Blast-Wave model fit of the $p_{\rm T}$-differential spectra of all nuclear species measured by the ALICE collaboration suggests that the $_{\Lambda}^{3}\mathrm{H}$ kinetic freeze-out surface is consistent with that of other nuclei. The ratio between the integrated yields of $_{\Lambda}^{3}\mathrm{H}$ and $^3\mathrm{He}$ is compared to predictions from the statistical hadronisation model and the coalescence model, with the latter being favoured by the presented measurements

Investigating Λ\Lambda baryon production in p-Pb collisions in jets and underlying event using angular correlations

International audienceFirst measurements of hadron(h)$-\Lambda$ azimuthal angular correlations in p$-$Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV using the ALICE detector at the LHC are presented. These correlations are used to separate the production of associated $\Lambda$ baryons into three different kinematic regions, namely those produced in the direction of the trigger particle (near-side), those produced in the opposite direction (away-side), and those whose production is uncorrelated with the jet-axis (underlying event). The per-trigger associated $\Lambda$ yields in these regions are extracted, along with the near- and away-side azimuthal peak widths, and the results are studied as a function of associated particle $p_{\rm T}$ and event multiplicity. Comparisons with the DPMJET event generator and previous measurements of the $\phi(1020)$ meson are also made. The final results indicate that strangeness production in the highest multiplicity p$-$Pb collisions is enhanced relative to low multiplicity collisions in the jet-like regions, as well as the underlying event. The production of $\Lambda$ relative to charged hadrons is also enhanced in the underlying event when compared to the jet-like regions. Additionally, the results hint that strange quark production in the away-side of the jet is modified by soft interactions with the underlying event

Measurement of the production cross section of prompt Ξ0c baryons in p–Pb collisions at √sNN = 5.02 TeV

The transverse momentum (pT) differential production cross section of the promptly-produced charm-strange baryon Ξ0c (and its charge conjugate Ξ0c¯¯¯¯¯¯) is measured at midrapidity via its hadronic decay into π+Ξ− in p−Pb collisions at a centre-of-mass energy per nucleon−nucleon collision sNN−−−√ = 5.02 TeV with the ALICE detector at the LHC. The Ξ0c nuclear modification factor (RpPb), calculated from the cross sections in pp and p−Pb collisions, is presented and compared with the RpPb of Λ+c baryons. The ratios between the pT-differential production cross section of Ξ0c baryons and those of D0 mesons and Λ+c baryons are also reported and compared with results at forward and backward rapidity from the LHCb Collaboration. The measurements of the production cross section of prompt Ξ0c baryons are compared with a model based on perturbative QCD calculations of charm-quark production cross sections, which includes only cold nuclear matter effects in p−Pb collisions, and underestimates the measurement by a factor of about 50. This discrepancy is reduced when the data is compared with a model in which hadronisation is implemented via quark coalescence. The pT-integrated cross section of prompt Ξ0c-baryon production at midrapidity extrapolated down to pT = 0 is also reported. These measurements offer insights and constraints for theoretical calculations of the hadronisation process. Additionally, they provide inputs for the calculation of the charm production cross section in p−Pb collisions at midrapidity