Gravitationally enhanced depolarization of ultracold neutrons in magnetic-field gradients

Trapped ultracold neutrons (UCN) have for many years been the mainstay of experiments to search for the electric dipole moment (EDM) of the neutron, a critical parameter in constraining scenarios of new physics beyond the Standard Model. Because their energies are so low, UCN preferentially populate the lower region of their physical enclosure, and do not sample uniformly the ambient magnetic field throughout the storage volume. This leads to a substantial increase in the rate of depolarization, as well as to shifts in the measured frequency of the stored neutrons. Consequences for EDM measurements are discussed

The Many Faces of Mitochondrial Autophagy: Making Sense of Contrasting Observations in Recent Research

Research into the selective autophagic degradation of mitochondria—mitophagy—has intensified in recent years, yielding significant insights into the function, mechanism, and regulation of this process in the eukaryotic cell. However, while some molecular players in budding yeast, such as Atg32p, Uth1p, and Aup1p, have been identified, studies further interrogating the mechanistic and regulatory features of mitophagy have yielded inconsistent and sometimes conflicting results. In this review, we focus on the current understanding of mitophagy mechanism, induction, and regulation in yeast, and suggest that differences in experimental conditions used in the various studies of mitophagy may contribute to the observed discrepancies. Consideration and understanding of these differences may help place the mechanism and regulation of mitophagy in context, and further indicate the intricate role that this essential process plays in the life and death of eukaryotic cells

A Fluorescence Microscopy Assay for Monitoring Mitophagy in the Yeast Saccharomyces cerevisiae

Autophagy is important for turnover of cellular components under a range of different conditions. It serves an essential homeostatic function as well as a quality control mechanism that can target and selectively degrade cellular material including organelles1-4. For example, damaged or redundant mitochondria (Fig. 1), not disposed of by autophagy, can represent a threat to cellular homeostasis and cell survival. In the yeast, Saccharomyces cerevisiae, nutrient deprivation (e.g., nitrogen starvation) or damage can promote selective turnover of mitochondria by autophagy in a process termed mitophagy 5-9

On track to achieve No Net Loss of forest at Madagascar’s biggest mine

Meeting the Sustainable Development Goals requires reconciling development with biodiversity conservation. Governments and lenders increasingly call for major industrial developments to offset unavoidable biodiversity loss, but there are few robust evaluations of whether offset interventions ensure No Net Loss (NNL) of biodiversity. We focus on the biodiversity offsets associated with the high-profile Ambatovy mine in Madagascar and evaluate their effectiveness at delivering NNL of forest. As part of their efforts to mitigate biodiversity loss, Ambatovy compensate for forest clearance at the mine site by slowing deforestation driven by small-scale agriculture elsewhere. Using a range of methods, including extensive robustness checks exploring 116 alternative model specifications, we show that the offsets are on track to avert as much deforestation as was caused by the mine. This encouraging result shows that biodiversity offsetting can contribute towards mitigating environmental damage from a major industrial development, even within a weak state, but there remain important caveats with broad application. Our approach could serve as a template to facilitate other evaluations and so build a stronger evidence-base of the effectiveness of No Net Loss interventions

The assembly of yeast mitochondrial ATP synthase: subunit depletion in vivo suggests ordered assembly of the stalk subunits b, OSCP and d

AbstractThe abundance in vivo of each of three subunits b, OSCP and d, components of the stalk region of the yeast mitochondrial ATP synthase complex, was manipulated by a controlled depletion strategy. Western blots of whole cell lysates were used to study the effect of depletion of each of these subunits on the cellular levels of other subunits of the enzyme complex. A hierarchy of subunit stability was determined and interpreted to indicate the order of assembly of these three subunits of the stalk region. Thus, subunit b is assembled first, followed by OSCP and then by subunit d

Lagrangian statistics of particle pairs in homogeneous isotropic turbulence

We present a detailed investigation of the particle pair separation process in homogeneous isotropic turbulence. We use data from direct numerical simulations up to Taylor's Reynolds number 280 following the evolution of about two million passive tracers advected by the flow over a time span of about three decades. We present data for both the separation distance and the relative velocity statistics. Statistics are measured along the particle pair trajectories both as a function of time and as a function of their separation, i.e. at fixed scales. We compare and contrast both sets of statistics in order to gain an insight into the mechanisms governing the separation process. We find very high levels of intermittency in the early stages, that is, for travel times up to order ten Kolmogorov time scales. The fixed scale statistics allow us to quantify anomalous corrections to Richardson diffusion in the inertial range of scales for those pairs that separate rapidly. It also allows a quantitative analysis of intermittency corrections for the relative velocity statistics.Comment: 16 pages, 16 figure

What did HERA teach us about the structure of the proton?

Starting in 2008 the H1 and ZEUS experiments have been combining their data in order to provide the most complete and accurate set of deep-inelastic data as the legacy of HERA. The present review presents these combinations, both published and preliminary, and explores how they have been used to give information on the structure of the proton. The HERAPDF parton distribution functions (PDFs) are presented and compared with other current PDFs and with data from the Tevatron and LHC colliders.Comment: 49 pages, 49 figures, to be published in J.Phys.

Search for the disappearance of muon antineutrinos in the NuMI neutrino beam

We report constraints on muon antineutrino oscillation parameters that were obtained by using the two MINOS detectors to measure the 7% antineutrino component of the NuMI neutrino beam. In the Far Detector, we select 130 events in the charged-current muon antineutrino sample, compared to a prediction of 136.4 +/- 11.7(stat) ^{+10.2}_{-8.9}(syst) events under the assumption |dm2bar|=2.32x10^-3 eV^2, snthetabar=1.0. A fit to the two-flavor oscillation approximation constrains |dm2bar|<3.37x10^-3 eV^2 at the 90% confidence level with snthetabar=1.0