PREPARATION AND EVALUATION OF MODIFIED TAMARIND SEED GUM AS A NOVEL SUPERDISINTEGRANT

The aim of present study was to preparation and evaluation of modified Tamarind seed as natural superdisintegrant. The extracted gum from the Tamarind seed was modified chemically by carboxymethylation of extracted gum was done to improve the hydrophilic nature of the gum. Futher, carboxymethylated gum was complexed by using calcium chloride to enhances  the wetting capacity of the gum. The modification in functional group of extracted gum, carboxymethyled gum, Calcium complexed gum was studied by FT-IR spectrophotometer. The DSC studies shows that the changes in melting point of the carboxymethyled gum and the calcium complexed gum as compared to the extracted gum without undergoing chemical modification. The modified gum was then subjected to different studies like color, pH of gum solution, swelling indexetc. The dummy tablet prepared with calcium complexed modified Tamarind seed gum to check its disintegration effect of the tablet. The various pre-compression parameters of the tablet blend was determined like bulk density, tapped density, Carr's index, angle of repose and Hausner's ratio. The disintegration time of these dummy tablet carry the calcium complexed tamarind seed gum was compared to formulate tablet with marketed superdisintegrant i.e. sodium starch glycolate . The disintegration time of calcium complexed Tamarind seed gum was observed to be 1 min. approx. 32.5 sec. -35.2 sec. showing good disintegrating property. It can be concluded that Fast disintegrating tablet using modified Tamarind seed gum as natural superdisintegrant improves the disintegration time of the tablet. Keywords: FDT tablet, Tamarind seed gum, Sodium starch glycolate, Swelling time.&nbsp

PREPARATION OF CONTROLLED RELEASE METFORMIN HYDROCHLORIDE LOADED CHITOSAN MICROSPHERES AND EVALAUTION OF FORMULATION PARAMETERS

In this work an attempt was made for the preparation and evaluation of controlled release chitosan microspheres using anti-diabetes drug Metformin hydrochloride. The microspheres were prepared by Ionotropic gelation method using chitosan as polymer and Sodium Tripolyphosphate (TPP) as crosslinking agent. The compatibility of drug and polymer is analyzed by using FTIR and DSC method. There was no interaction detected by FTIR and DSC study. Further the prepared microspheres were evaluated for particle size, drug entrapment efficiency, surface morphology, drug content, drug loading and in vitro drug release. Amongst all the formulation batch 7 shows the best release when compared to other batch. SEM (Scanning electron microscopy) revealed that microspheres were spherical and porous. Finally it was concluded that Metformin hydrochloride loaded chitosan – TPP microspheres have been found suitable for controlled release formulation due to its bioavailability and biodegradability and thus lead to improved patient compliance. Keywords: Microspheres, Metformin hydrochloride, Ionotropic gelation method, chitosan