Neuronale und Genetische Algorithmen auf Parallelrechnern in der Genomforschung. Teilvorhaben: Neuronale und genetische Algorithmen zur Analyse von Protein- und Nucleinsequenzen und zur Proteinstrukturvorhersage Abschlussbericht

In this project new (connectionable) systems were developed to predict- in combination with Genetic Algorithms (GA) - the tertiary structur of proteins and to recognize signals in DNA and proteins. We are able to show the advantage of using Neuronal Network instead of using other analytical tools in this area. A main methodically request is the formulation and development of specialized software which can be used on parallized high performanced computers. One example is the software package DIANA (Dna Interactive Artifical Neural Network Analysis). DIANA is an analysis tool for predicting the positions of splice sites and coding regions in the human genes. The problem of protein folding can be separated in several subdivisions depending on the different detailled aspects you want to predict out of the sequence. We are able to predict the following: local loop geometries, water-accessible surface areas, approximate backbone geometries for proteins of medium-range sequence homology as well as protein domains and folding classes of proteins lacking significant sequence homology to proteins of known structure. All these problems were solved by using high power neuronal networks and a well fitted coding of the problem. It should be mentioned that all our results have a better accuracy than statistical and symbolic methods. In the third part of our project we minimized protein structures using Genetic Algorithms (GA). The main advantage of this method is that it predicts the global minimum of the structure and not only a local one as other well-known methods do. Prediction of protein structure was done for different kind of peptide analogues and for Met-Enkephalin. For the first group of proteines we were able to find the global minimum but the result for second group was not satisfying. (orig.)Available from TIB Hannover: F97B1099+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Genome Computing Resource - Bioinformatik-Infrastruktur des Deutschen Humangenomprojektes Schlussbericht

SIGLEAvailable from TIB Hannover: DtF QN1(90,48) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Weiterentwicklung verteilter, heterogener Datenbanksysteme und ihre Anwendung in der Genomforschung Abschlussbericht

Available from TIB Hannover: F97B1098+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Computerunterstuetztes Editieren genomischer Sequenzen Schlussbericht

Available from TIB Hannover: DtF QN1(89,19) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman