Показатели развития городских образовательных институтов как факторов экономического и пространственного развития города и городской агломерации, с опорой на результаты международных исследований, посвященных данной проблематике

In the current economic situation, both in the Russian Federation and in the developed countries of the world, the education system is increasingly becoming a factor in successful economic and spatial development

Дата-грамостность и наука о данных: Образовательные подходы и решения

In the context of fundamental changes in the economy and the labor market, the introduction of educational programs in the field of data analysis and machine learning at all levels of education with the priority of integrating mathematical, natural science and socio-humanitarian knowledge becomes important. An overview and analysis of foreign experience and main discussion topics in the development of educational modules for data science and machine learning for adolescents and adolescents is presented

Crimean-Congo haemorrhagic fever virus in Kazakhstan (1948-2013)

AbstractCrimean-Congo haemorrhagic fever (CCHF) is a pathogenic and often fatal arboviral disease with a distribution spanning large areas of Africa, Europe and Asia. The causative agent is a negative-sense single-stranded RNA virus classified within the Nairovirus genus of the Bunyaviridae family.Cases of CCHF have been officially recorded in Kazakhstan since the disease was first officially reported in modern medicine. Serological surveillance of human and animal populations provide evidence that the virus was perpetually circulating in a local enzoonotic cycle involving mammals, ticks and humans in the southern regions of the country. Most cases of human disease were associated with agricultural professions such as farming, shepherding and fruit-picking; the typical route of infection was via tick-bite although several cases of contact transmission associated with caring for sick patients have been documented.In total, 704 confirmed human cases of CCHF have been registered in Kazakhstan from 1948-2013 with an overall case fatality rate of 14.8% for cases with a documented outcome.The southern regions of Kazakhstan should be considered endemic for CCHF with cases reported from these territories on an annual basis. Modern diagnostic technologies allow for rapid clinical diagnosis and for surveillance studies to monitor for potential expansion in known risk areas

Biosurveillance in Central Asia: Successes and Challenges of Tick-Borne Disease Research in Kazakhstan and Kyrgyzstan

Central Asia is a vast geographic region that includes five former Soviet Union republics: Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. The region has a unique infectious disease burden, and a history that includes Silk Road trade routes and networks that were part of the anti-plague and biowarfare programs in the former Soviet Union. Post Soviet Union biosurveillance research in this unique area of the world has met with several challenges, including lack of funding and resources to independently conduct hypothesis driven, peer-review quality research. Strides have been made, however, to increase scientific engagement and capability. Kazakhstan and Kyrgyzstan are examples of countries where biosurveillance research has been successfully conducted, particularly with respect to especially dangerous pathogens. In this review we describe in detail the successes, challenges and opportunities of conducting biosurveillance in Central Asia as exemplified by our recent research activities on ticks and tick-borne diseases in Kazakhstan and Kyrgyzstan

Data Literacy as a meta-skill: options for Data Science curriculum implementation

Data science is affecting an increasingly wide area of everyday life but general education in Russia has not yet reacted to the new challenges associated with this aspect of digitalization. The changes in technologies, the economy, and society over the last two decades have formed a new agenda for teaching mathematics and information technologies, as well as media education and social sciences. Education in all these fields requires a reconsideration of the content and methods of teaching due to the increasing importance of data science and artificial intelligence in the context of fundamental changes in the economy and the labor market. As many areas of human life are changing, there is a need to formulate new types and kinds of educational results, at which modern pedagogy should be aimed. A modern way of meeting such challenges is to distinguish new literacies (media literacy, environmental literacy, functional literacy, etc.). The article deals with the concept of data literacy, examines its content and composition, and substantiates its relevance as an educational result consistent with digitalization trends that one can observe in modern society. A distinction is made between approaches to in-depth and general studies of data science. A description is given of various types of tasks aimed at developing data literacy among students in the context of their setting on different educational material. The authors consider possible ways of deploying programs aimed at mastering data science by students without the need to formalize it into a separate discipline or school subject

Data-gravity and Data Science: Educational Approaches and Solutions

In the context of fundamental changes in the economy and the labor market, the introduction of educational programs in the field of data analysis and machine learning at all levels of education with the priority of integrating mathematical, natural science and socio-humanitarian knowledge becomes important. An overview and analysis of foreign experience and main discussion topics in the development of educational modules for data science and machine learning for adolescents and adolescents is presented

Indicators of the Development of Urban Educational Institutions As Factors of the Economic and Spatial Development of the City and Urban Agglomeration, Based on the Results of International Studies Devoted to This Issue

In the current economic situation, both in the Russian Federation and in the developed countries of the world, the education system is increasingly becoming a factor in successful economic and spatial development

Targeting Multiple Homeostasis-Maintaining Systems by Ionophore Nigericin Is a Novel Approach for Senolysis

Within the present study we proposed a novel approach for senolysis based on the simultaneous disturbance of the several homeostasis-maintaining systems in senescent cells including intracellular ionic balance, energy production and intracellular utilization of damaged products. Of note, we could not induce senolysis by applying ouabain, amiloride, valinomycin or NH4Cl—compounds that modify each of these systems solely. However, we found that ionophore nigericin can disturb plasma membrane potential, intracellular pH, mitochondrial membrane potential and autophagy at once. By affecting all of the tested homeostasis-maintaining systems, nigericin induced senolytic action towards stromal and epithelial senescent cells of different origins. Moreover, the senolytic effect of nigericin was independent of the senescence-inducing stimuli. We uncovered that K+ efflux caused by nigericin initiated pyroptosis in senescent cells. According to our data, the higher sensitivity of senescent cells compared to the control ones towards nigericin-induced death was partially mediated by the lower intracellular K+ content in senescent cells and by their predisposition towards pyroptosis. Finally, we proposed an interval dosing strategy to minimize the negative effects of nigericin on the control cells and to achieve maximal senolytic effect. Hence, our data suggest ionophore nigericin as a new senotherapeutic compound for testing against age-related diseases