10 research outputs found
Association between Apert Syndrome and Atrial Septal Defect
Apert syndrome, craniosynostosis, mid-face hypoplasia, symmetric syndactyly of the hands and feet, and varying degrees of mental retardation, and is characterized by congenital heart defects. Although the mode of inheritance is autosomal dominant, it creates new mutations in the majority of cases. In this study, an atrial septal defect cases of Apert syndrome, concomitant potential for congenital heart defects, in order to emphasize further investigation, we were willing to offer
Myopericarditis mimicking acute coronary syndrome in children
Akut miyoperikardit perimyokardiyumun inflamasyonuyla seyreden tabloyu tanımlar. Bu tablodaperikardit genellikle, aynı etyolojik ajanları paylaşmaları nedeniyle, kardiyak troponin değerlerindeartışla kendini gösteren çeşitli derecelerde miyokard tutulumu ile birliktedir. Etyolojide enfeksiyöz,idyopatik ve immün nedenler sorumlu tutulur. En sık nedeni viral enfeksiyonlardır. Hastaların kliniğinimyokard tutulumunun derecesi belirler. Burada özellikle yatarken artan göğüs ağrısı yakınması ilebaşvuran, elektrokardiyografisinde yaygın ST segment elevasyonu ve kardiyak enzim yüksekliğisaptanan on altı yaşında bir myoperikardit olgusu sunuldu.Acute myopericarditis defines an inflammatory syndrome which affects perimyocardium. In this clinical event, pericarditis is often accompanied by some degree of myocardial involvement, which is generally manifested by elevation of cardiac troponins. Main etiologic factors are infectious, idiopathic and immune mediated agents. The most common causes are viral infections. The clinical presentation of myopericarditis reflects the degree of myopericardial involvement. This article reports a myopericarditis event diagnosed at sixteen years old patient who presented with chest pain that increases when lying down and ST segment elevations and elevated cardiac enzymes
Effects of gestational and pregestational diabetes mellitus on the foetal heart: a cross-sectional study
We examined the foetal cardiac structural and functional characteristics in diabetic pregnancies versus non-diabetic, healthy pregnancies. Between August 2015 and April 2016, 32 pregnant women with pregestational diabetes, 36 pregnant women with gestational diabetes, and 42 healthy pregnant women were scheduled to have foetal echocardiograms to assess cardiac structure and function. In the diabetic groups, the foetal interventricular septum (IVS) thickness was significantly greater than in non-diabetics (p2 SD from normal. The peak velocity of tricuspid E, and the E/A ratio were significantly lower in the diabetic groups (p.05). Interventricular septal hypertrophy is the most common structural abnormality in diabetic pregnancies. These changes do not pose a risk to the foetal unless they cause functional impairment. Thus, we believe that it is important for diabetic pregnant women to be monitored for foetal cardiac diastolic dysfunction.Impact statementWhat is already known on this subject? Pregestational insulin-dependent diabetes mellitus is a relatively common condition in pregnancy, affecting up to 0.5% of the pregnant population. Foetuses of diabetic mothers are at an increased risk of perinatal morbidity and death. Gestational diabetes mellitus is under-recognised and affects up to 4% of pregnancies. Although diabetes mellitus is known to increase the risk of cardiovascular defects and structural changes (myocardial hypertrophy and diastolic dysfunction) due to foetal hyperglycaemia and hyperinsulinism, similar data in women with gestational diabetes is scarce. Moreover, the effect of maternal hyperglycaemia on foetal cardiac structure and function is unclear because of discordant results from previous studies.What do the results of this study add? In this study, we have used foetal echocardiography, two-dimensional US, pulsed wave Doppler and TDI to characterise the foetal cardiac structure and function in normal pregnancies as well as in the pregnancies complicated by GDM, and pregestational DM. Interventricular septum thickness is increased in women with pregestational diabetes mellitus and impaired diastolic function. The dominant right ventricle of the foetal circulation was affected earlier than the left ventricle.What are the implications of these findings for clinical practice and/or further research? Large population-based studies are required to establish the absolute risk of congenital heart defects in patients with pregestational diabetes and pregestational diabetes in the utility of routine screening
Myopericarditis Mimicking Acute Coronary Syndrome in Children
Acute myopericarditis defines an inflammatory syndrome which affects perimyocardium. In this clinical event, pericarditis is often accompanied by some degree of myocardial involvement, which is generally manifested by elevation of cardiac troponins. Main etiologic factors are infectious, idiopathic and immune mediated agents. The most common causes are viral infections. The clinical presentation of myopericarditis reflects the degree of myopericardial involvement. This article reports a myopericarditis event diagnosed at sixteen years old patient who presented with chest pain that increases when lying down and ST segment elevations and elevated cardiac enzymes
Usefulness of soluble urokinase plasminogen activator receptor (suPAR) as an inflammatory biomarker in obese children
Conclusion: Our research did not demonstrate the usefulness of suPAR as an inflammatory biomarker and a predictive value for future atherosclerosis in obese children. Further studies with larger sample size are required to determine whether suPAR is useful as an inflammatory biomarker in childhood obesity. (C) 2016 Elsevier Ireland Ltd. All rights reserved
Salusin-α levels are negatively correlated with diastolic blood pressure in children with obesity
The Cost Analysis of Preterm Infants from a NICU of a State Hospital in Istanbul
Objective: The objective of this study was assessment of hospital costs
of 211 preterm babies admitted to NICU in a 12-month period. Methods:
Preterm babies with gestational age 28-37 GW hospitalized in Dr. L.
Kırdar Kartal Research and Training Hospital NICU between November
1st, 2006 to October 31st, 2007 were included in this retrospective
study. The financial records of the babies were plotted and
investigational, interventional, consumable costs, drugs and ancillary
costs were determined. The average daily cost of a preterm has been
determined. Group I and II consisted of babies with gestational ages
37-33 GW and 32-28 GWs respectively. The length of stay, ventilation
duration and costs of each group were compared. Findings: The mean
birth weight was 1689±497 gr. The mean length of hospital stay was
13.6±13.4 days. Hundred and four (49,5%) patients were found to be
ventilated. The median ventilation day was 3 days. We found a
statistically significant relation between length of hospital stay,
ventilation duration, presence of intervention, RDS, sepsis and
hospital costs. The mean total hospitalization cost and the daily cost
of a preterm was determined as 303 respectively. The highest
intensive care costs of preterm neonates were found to be paid for
interventional procedures, followed by NICU personnel salary and
ancillary costs. Between two groups statistically significant
difference was found for length of stay, duration of ventilation,
interventional and consumable costs (P=0.014, P=0.019, P=0,001, P=0.03
respectively). Conclusion: Strategies for prevention of prematurity and
early weaning from mechanical ventilation may shorten length of
hospital stay leading to decreased NICU costs