498 research outputs found
Cross-Layer Optimization of Fast Video Delivery in Cache-Enabled Relaying Networks
This paper investigates the cross-layer optimization of fast video delivery
and caching for minimization of the overall video delivery time in a two-hop
relaying network. The half-duplex relay nodes are equipped with both a cache
and a buffer which facilitate joint scheduling of fetching and delivery to
exploit the channel diversity for improving the overall delivery performance.
The fast delivery control is formulated as a two-stage functional non-convex
optimization problem. By exploiting the underlying convex and quasi-convex
structures, the problem can be solved exactly and efficiently by the developed
algorithm. Simulation results show that significant caching and buffering gains
can be achieved with the proposed framework, which translates into a reduction
of the overall video delivery time. Besides, a trade-off between caching and
buffering gains is unveiled.Comment: 7 pages, 4 figures; accepted for presentation at IEEE Globecom, San
Diego, CA, Dec. 201
Cache-Aided Non-Orthogonal Multiple Access
In this paper, we propose a novel joint caching and non-orthogonal multiple
access (NOMA) scheme to facilitate advanced downlink transmission for next
generation cellular networks. In addition to reaping the conventional
advantages of caching and NOMA transmission, the proposed cache-aided NOMA
scheme also exploits cached data for interference cancellation which is not
possible with separate caching and NOMA transmission designs. Furthermore, as
caching can help to reduce the residual interference power, several decoding
orders are feasible at the receivers, and these decoding orders can be flexibly
selected for performance optimization. We characterize the achievable rate
region of cache-aided NOMA and investigate its benefits for minimizing the time
required to complete video file delivery. Our simulation results reveal that,
compared to several baseline schemes, the proposed cache-aided NOMA scheme
significantly expands the achievable rate region for downlink transmission,
which translates into substantially reduced file delivery times.Comment: Accepted for presentation at IEEE ICC 201
Social Media and the perfect crime: Towards the death of reality, representation and the murder of resistance.
Master'sMASTER OF ART
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Metastatic Renal Cell Carcinoma to the Sinonasal Cavity: A Case Series
Objectives: To describe the presentation, work-up, and management of patients with metastatic renal cell carcinoma (RCC) to the sinonasal cavity and skull base, and to describe our current treatment algorithm of endoscopic surgical resection followed by radiation therapy. Design: Retrospective review of two recent cases from our institution over a 1-year period, with a relevant review of the literature. Setting: A large regional tertiary care facility. Participants: Consecutive cases of RCC with metastases to the sinonasal cavity presenting to our institution. Main Outcome Measures: Preoperative and postoperative sinonasal outcome test (SNOT)-22 scores, duration of hospital stay, complications, and local disease control Results: Patients in this series underwent preoperative embolization followed by endoscopic resection without complication. Postoperatively they were treated with radiation therapy. They experienced improvement in their SNOT-22 scores and are currently free of local disease. Conclusion: Metastatic RCC to the sinonasal cavity can be safely treated with preoperative embolization followed by endoscopic surgical resection and radiation therapy, which can result in improvement in sinonasal quality of life and is a potential adjunct for local control of disease
Implantation Serine Proteinases heterodimerize and are critical in hatching and implantation
BACKGROUND: We have recently reported the expression of murine Implantation Serine Proteinase genes in pre-implantation embryos (ISP1) and uterus (ISP1 and ISP2). These proteinases belong to the S1 proteinase family and are similar to mast cell tryptases, which function as multimers. RESULTS: Here, we report the purification and initial characterization of ISP1 and 2 with respect to their physico-chemical properties and physiological function. In addition to being co-expressed in uterus, we show that ISP1 and ISP2 are also co-expressed in the pre-implantation embryo. Together, they form a heterodimer with an approximate molecular weight of 63 kD. This complex is the active form of the enzyme, which we have further characterized as being trypsin-like, based on substrate and inhibitor specificities. In addition to having a role in embryo hatching and outgrowth, we demonstrate that ISP enzyme is localized to the site of embryo invasion during implantation and that its activity is important for successful implantation in vivo. CONCLUSION: On the basis of similarities in structural, chemical, and functional properties, we suggest that this ISP enzyme complex represents the classical hatching enzyme, strypsin. Our results demonstrate a critical role for ISP in embryo hatching and implantation
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