3 research outputs found
Molecular models of human P-glycoprotein in two different catalytic states
P-glycoprotein belongs to the family of ATP-binding cassette proteins which hydrolyze ATP to catalyse the translocation of their substrates through membranes. This protein extrudes a large range of components out of cells, especially therapeutic agents causing a phenomenon known as multidrug resistance. Because of its clinical interest, its activity and transport function have been largely characterized by various biochemical studies. In the absence of a high-resolution structure of P-glycoprotein, homology modeling is a useful tool to help interpretation of experimental data and potentially guide experimental studies.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe
Study by molecular modelling and simulations of twoABC exporters: P-gp and SAV1866
info:eu-repo/semantics/nonPublishe
Study of Conformational States of ABC exporters by Computer Modeling and Molecular Dynamics Simulations
info:eu-repo/semantics/nonPublishe