Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells <i>in vitro</i>

A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay. The results showed that the novel compound had antiproliferative activity toward MC-38 and HT-29 cells in a dose-dependent manner. The cell cycle analysis by flow cytometry indicated that compound 6 exerted in tumor cell proliferation inhibition by arresting HT-29 cells in the G2/M phase. In addition, cell death detected by propidium iodide staining showed that compound 6 efficiently induced cell apoptosis in a concentration-dependent manner. Moreover, the sensitivity of human fibroblast cells to compound 6 was far lower than that of tumor cells, suggesting the specific anti-tumor effect of 4-thio-5-(2′′-thienyl)uridine. Taken together, novel compound 6 effectively inhibits colon cancer cell proliferation, and hence would have potential value in clinical application as an antitumor agent

Phase diagram of a frustrated asymmetric ferromagnetic spin ladder

We perform a systematic investigation on the ground state of an asymmetric two-leg spin ladder (where exchange couplings of the legs are unequal) with ferromagnetic (FM) nearest-neighbor interaction and diagonal anti-ferromagnetic frustration using the Density Matrix Renormalization Group (DMRG) method. When the ladder is strongly asymmetric with moderate frustration, a magnetic canted state is observed between a FM state and a singlet dimerized state. The phase boundaries are dependent on the asymmetric strength $\alpha_{a}$. On the other hand, when the asymmetric strength is intermediate, a so-called spin-stripe state (spins align parallel on same legs, but antiparallel on rungs) is discovered, and the system experiences a first-order phase transition from the FM state to the spin-stripe state upon increasing frustration. We present numerical evidence to interpret the phase diagram in terms of frustration and the asymmetric strength.Comment: 14 pages, 8 figure

Understanding Mobile Traffic Patterns of Large Scale Cellular Towers in Urban Environment

Understanding mobile traffic patterns of large scale cellular towers in urban environment is extremely valuable for Internet service providers, mobile users, and government managers of modern metropolis. This paper aims at extracting and modeling the traffic patterns of large scale towers deployed in a metropolitan city. To achieve this goal, we need to address several challenges, including lack of appropriate tools for processing large scale traffic measurement data, unknown traffic patterns, as well as handling complicated factors of urban ecology and human behaviors that affect traffic patterns. Our core contribution is a powerful model which combines three dimensional information (time, locations of towers, and traffic frequency spectrum) to extract and model the traffic patterns of thousands of cellular towers. Our empirical analysis reveals the following important observations. First, only five basic time-domain traffic patterns exist among the 9,600 cellular towers. Second, each of the extracted traffic pattern maps to one type of geographical locations related to urban ecology, including residential area, business district, transport, entertainment, and comprehensive area. Third, our frequency-domain traffic spectrum analysis suggests that the traffic of any tower among the 9,600 can be constructed using a linear combination of four primary components corresponding to human activity behaviors. We believe that the proposed traffic patterns extraction and modeling methodology, combined with the empirical analysis on the mobile traffic, pave the way toward a deep understanding of the traffic patterns of large scale cellular towers in modern metropolis.Comment: To appear at IMC 201

Vertical vs. Adiabatic Ionization Energies in Solution and Gas-Phase: Probing Ionization-Induced Reorganization in Conformationally-Mobile Bichromophoric Actuators Using Photoelectron Spectroscopy, Electrochemistry and Theory

Ionization-induced structural and conformational reorganization in various π-stacked dimers and covalently linked bichromophores is relevant to many processes in biological systems and functional materials. In this work, we examine the role of structural, conformational, and solvent reorganization in a set of conformationally mobile bichromophoric donors, using a combination of gas-phase photoelectron spectroscopy, solution-phase electrochemistry, and density functional theory (DFT) calculations. Photoelectron spectral analysis yields both adiabatic and vertical ionization energies (AIE/VIE), which are compared with measured (adiabatic) solution-phase oxidation potentials (Eox). Importantly, we find a strong correlation of Eox with AIE, but not VIE, reflecting variations in the attendant structural/conformational reorganization upon ionization. A careful comparison of the experimental data with the DFT calculations allowed us to probe the extent of charge stabilization in the gas phase and solution and to parse the reorganizational energy into its various components. This study highlights the importance of a synergistic approach of experiment and theory to study ionization-induced structural and conformational reorganization

Selfishness in device-to-device communication underlaying cellular networks

In a device-to-device (D2D) communication underlaying cellular network, user equipments are required to operate cooperatively and unselfishly to transmit data as relays. However, most users behave in a more or less selfish way, which makes user selfishness a key factor that affects the performance of the whole communication system. We focus on the impact of node selfishness on D2D communications. By separating the user selfishness into two types in accordance with two D2D transmission modes – connected D2D transmission and opportunistic D2D transmission, we propose a time-varying graph model that characterizes the impacts of both individual and social selfishness on D2D communications. Simulation results obtained under the realistic networking settings indicate that the interaction between connected and opportunistic selfishness worsens the impairment caused by individual selfishness, while the harmful interaction caused by social selfishness can be alleviated

Characterization of behaviour and hazards of fire and deflagration for high-energy Li-ion cells by over-heating

Fire and deflagration are extreme manifestation of thermal runaway (TR) of Li-ion cells, and they are characterized for fully charged LiNiCoAlO2 (LNCA) 18650 cells in this investigation. The cells are over-heated using a cone calorimeter under different incident heat fluxes. When the cells are exposed to the incident heat flux larger than 35 kW m−2, both fire and deflagration present. The pressure valve opens when the temperature of the cell is higher than 132 °C. The fire occurs with the valve opening when the concentration of the venting vapour in the air is higher than the lower flammability limit. The deflagration happens after the cell temperature arrives about 200 °C, and is mainly arising from the cathode decomposition, the combustion of solvents and the anode relevant thermal reactions. The extreme temperatures of the cell and the flame during deflagration are over than 820 and 1035 °C, respectively. The production of COx, mass loss, heat release rate (HRR) are quantitative identified, and are found increase as the increasing incident heat flux. Based on revised oxygen consumption method, the HRR and liberated heat during the fire and deflagration for the cells are up to 11.8 ± 0.05 kW and 163.1 ± 1.5 kJ, respectively