2 research outputs found
Fundus topographical distribution patterns of ocular toxoplasmosis
BACKGROUND: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions. METHODS: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed. RESULTS: 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola. CONCLUSION: The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease
Fundus Topographical Distribution Patterns of Ocular Toxoplasmosis
Background: To establish topographic maps and determine fundus distribution patterns of ocular toxoplasmosis (OT) lesions.Methods: In this retrospective study, patients who presented with OT to ophthalmology clinics from four countries (Argentina, Turkey, UK, USA) were included. Size, shape and location of primary (1°)/recurrent (2°) and active/inactive lesions were converted into a two-dimensional retinal chart by a retinal drawing software. A final contour map of the merged image charts was then created using a custom Matlab programme. Descriptive analyses were performed.Results: 984 lesions in 514 eyes of 464 subjects (53% women) were included. Mean area of all 1° and 2° lesions was 5.96±12.26 and 5.21±12.77 mm2, respectively. For the subset group lesions (eyes with both 1° and 2° lesions), 1° lesions were significantly larger than 2° lesions (5.52±6.04 mm2 vs 4.09±8.90 mm2, p=0.038). Mean distances from foveola to 1° and 2° lesion centres were 6336±4267 and 5763±3491 µm, respectively. The majority of lesions were found in temporal quadrant (p<0.001). Maximum overlap of all lesions was at 278 µm inferotemporal to foveola.Conclusion: The 1° lesions were larger than 2° lesions. The 2° lesions were not significantly closer to fovea than 1° lesions. Temporal quadrant and macular region were found to be densely affected underlining the vision threatening nature of the disease.Keywords: Choroid; Imaging; Infection; Inflammation; RetinaFil: Hasanreisoglu, Murat. Koc University School of Medicine; TurquÃa. Gazi University School of Medicine; TurquÃaFil: Halim, Muhammad Sohail. Ocular Imaging Research and Reading Center; Estados UnidosFil: Cakar Ozdal, Pinar. University of Health Sciences Ankara Ulucanlar Eye Training and Research Hospital; TurquÃaFil: Ormaechea, Maria Soledad. Universidad Catolica de Las Misiones. Facultad de Cs. de la Salud; ArgentinaFil: Kesim, Cem. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Ozdemir, Huseyin Baran. Universidad Austral. Hospital Universitario Austral. Departamento de CirugÃa. Servicio de Oftalmologia.; ArgentinaFil: Uludag, Gunay. University of Stanford; Estados UnidosFil: Sredar, Nripun. University of Stanford; Estados UnidosFil: Cankurtaran, Mahmut. University of Health Sciences Ankara Ulucanlar Eye Training and Research Hospital; TurquÃaFil: Liu, Xiaoxuan. University Hospitals Birmingham NHS Foundation Trust; Reino Unido. University Of Birmingham; . Moorfields Eye Hospital NHS Foundation Trust; Reino UnidoFil: Denniston, Alastair Keith. University Hospitals Birmingham NHS Foundation Trust; Reino Unido. University Of Birmingham; . Moorfields Eye Hospital NHS Foundation Trust; Reino UnidoFil: Rudzinski, Marcelo Nicolas. Universidad Catolica de Las Misiones; Argentina. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Colombero, Daniel N.. Universidad Nacional de Rosario; ArgentinaFil: Schlaen, Bernardo Ariel. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Keane, Pearse Andrew. Moorfields Eye Hospital NHS Foundation Trust; Estados UnidosFil: Pavesio, Carlos. Moorfields Eye Hospital NHS Foundation Trust; Estados Unidos. University of Lincoln; Reino UnidoFil: Nguyen, Quan Dong. University of Stanford; Estados Unido