13 research outputs found
508 STEROIDOGENIC PROPERTIES OF PROSTATE CANCER CELL-LINES: PROOF FOR INTRACRINE ANDROGEN METABOLISM?
Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer
Natural Products as Starting Materials for Development of Second Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells
An analysis of the binding of the 8 O N tert butoxycarbonyl 12 aminododecanoyl derivative of 8 O debutanoylthapsigargin to the target molecule, the SERCA pump, has revealed the importance of the length and flexibility of the side chain attached to O 8. Based on the analysis a series of analogues to the 2 unsubstituted analogue trilobolide has been constructed and shown to be equipotent with thapsigargin as SERCA inhibitors. Only the 12 Boc aminododecaonoyl derivative, however, was found to be apoptoti