Dreams

https://digitalcommons.library.umaine.edu/mmb-vp/4188/thumbnail.jp

In Twilight Town

https://digitalcommons.library.umaine.edu/mmb-vp/3628/thumbnail.jp

Darby And Joan

https://digitalcommons.library.umaine.edu/mmb-vp/1270/thumbnail.jp

I Want A Girl From Home Sweet Home

https://digitalcommons.library.umaine.edu/mmb-vp/1702/thumbnail.jp

Study of Laminar-Turbulent Transition Modeled by Amplification Factor Transport Within the LAVA Solver

The Amplification Factor Transport (AFT) transition model proposed by Coder and Maughmer is implemented in the unstructured and curvilinear Reynolds-Averaged Navier-Stokes (RANS) solvers of the Launch Ascent and Vehicle Aerodynamics (LAVA) platform. It is coupled to the Spalart-Allmaras (SA) turbulence model through a modified intermittency variable. As part of the model verification and validation phase, laminar-turbulent transition is studied over 2D flat plates, wind turbine and general aviation airfoils, as well as a 3D inclined prolate spheroid and the JAXA Standard Model (JSM). This work will analyze the sensitivity of the results to grid refinement, grid paradigm, flow conditions and numerical schemes. The numerical efficiency of the unstructured and curvilinear solvers will be compared and convergence acceleration techniques will be explored to address a broad range of aerodynamics applications

Comparative analysis of homology models of the Ah receptor ligand binding domain: Verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the biological and toxic effects of a wide variety of structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). While significant interspecies differences in AHR ligand binding specificity, selectivity, and response have been observed, the structural determinants responsible for those differences have not been determined, and homology models of the AHR ligand-binding domain (LBD) are available for only a few species. Here we describe the development and comparative analysis of homology models of the LBD of 16 AHRs from 12 mammalian and nonmammalian species and identify the specific residues contained within their ligand binding cavities. The ligand-binding cavity of the fish AHR exhibits differences from those of mammalian and avian AHRs, suggesting a slightly different TCDD binding mode. Comparison of the internal cavity in the LBD model of zebrafish (zf) AHR2, which binds TCDD with high affinity, to that of zfAHR1a, which does not bind TCDD, revealed that the latter has a dramatically shortened binding cavity due to the side chains of three residues (Tyr296, Thr386, and His388) that reduce the amount of internal space available to TCDD. Mutagenesis of two of these residues in zfAHR1a to those present in zfAHR2 (Y296H and T386A) restored the ability of zfAHR1a to bind TCDD and to exhibit TCDD-dependent binding to DNA. These results demonstrate the importance of these two amino acids and highlight the predictive potential of comparative analysis of homology models from diverse species. The availability of these AHR LBD homology models will facilitate in-depth comparative studies of AHR ligand binding and ligand-dependent AHR activation and provide a novel avenue for examining species-specific differences in AHR responsiveness. © 2013 American Chemical Society

Awareness, Co-operation, Tackling to Stop Sexual Bullying: An empowerment pack for young people and the people working with them (The ACT Pack).

Available in English, Bulgarian, Slovenian and Italia

Assessing maternal anxiety in pregnancy with the State-Trait Anxiety Inventory (STAI): Issues of validity, location and participation

The State Trait Anxiety Inventory (STAI) has been widely used in research with pregnant women. However, few studies have examined its validity for this group. In this paper the content validity of the STAI, the impact of location and consequences for further participation of higher STAI scores are investigated for 215 pregnant women who completed the STAI at hospital or community based clinics. The study participants answered the open ended question, 'How do you feel about your pregnancy?' and whether or not they would be willing to take part in further research. Results indicated that STAI state scores reflected the nature of women's spontaneous comments regarding their pregnancy, with lower anxiety related to more 'positive' comments. The state scores were also found to be sensitive to the risk level associated with the clinic where the inventory was completed; higher scores related to high-risk localities. Women with the highest levels of state or trait anxiety were also less likely to wish to take part in further research. The study concludes that the STAI does reflect the anxiety-related experiences of pregnant women and that its use with pregnant women is appropriate in this respect; however, we recommend that future research notes the issue of potential recruitment biases. 2010 Society for Reproductive and Infant Psychology.CIHR28pub183