Orthodontic mini-implants: A systematic review.

 AbstractPurposeTo compile and analyze the literature regarding orthodontic mini-implants (MIs) placement, clinical applications, success rate, adverse effects and patients’ pain experience in clinical practice.MethodologyPublications about orthodontic MIs variables were systematically searched from PubMed, Science Direct, and Google Scholar Beta electronic data bases using “orthodontic in conjunction with implant, microimplant, screw, miniscrew, screw implant, mini-implant, and temporary anchorage” as keywords. Data from selected articles were extracted and compiled to produce a summarized report. ResultsSeveral areas are suitable for MI placement. However; the region between second premolar and first molar is the safest. The MI success rate ranges from 77.7% to 93.43%. The pain associated with MIs is far less than tooth extraction and significantly lower than patients’ expectation. Root resorption is among the adverse effects and gonial angle pattern influences the MI success rate. ConclusionMIs offer a wide range of clinical anchorage application due to their minimal anatomical location limitation. The success rate of MI is reliably high. The pain caused by orthodontics MI is significantly lower than patients’ expectation. &nbsp

The Antidepressant Effect of Angelica sinensis

Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive impairments. However, until recently, few studies had explored its antidepressant effect. The current study attempts to investigate the effect of AS extracts on chronic unpredictable mild stress- (CUMS-) induced depression in rats. Male SD rats were exposed to a CUMS-inducing procedure for 5 weeks, resulting in rodent depressive behaviors that included reduced sucrose consumption and lessened sucrose preference ratios in sucrose preference test, prolonged immobility times and decreased struggling time in force swim test, and decreased locomotor activity in open field test. Moreover, the expression of brain derived neurotrophic factor (BDNF) and the phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal-regulated protein kinase (ERK 1/2) were markedly decreased in the hippocampus in depressed rats. However, chronically treating the depressed rats with AS (1 g/kg) normalized their depression-related behaviors and molecular profiles. In conclusion, in the present study, we show that AS extracts exerted antidepressant effects that were mediated by the BDNF signaling pathway: in AS-treated depressed rats, the expression of the BDNF protein and the phosphorylation of its downstream targets (ERK 1/2, CREB) were upregulated in the hippocampus

Achievements and challenges in bioartificial kidney development

Bioartificial kidneys (BAKs) combine a conventional hemofilter in series with a bioreactor unit containing renal epithelial cells. The epithelial cells derived from the renal tubule should provide transport, metabolic, endocrinologic and immunomodulatory functions. Currently, primary human renal proximal tubule cells are most relevant for clinical applications. However, the use of human primary cells is associated with many obstacles, and the development of alternatives and an unlimited cell source is one of the most urgent challenges. BAKs have been applied in Phase I/II and Phase II clinical trials for the treatment of critically ill patients with acute renal failure. Significant effects on cytokine concentrations and long-term survival were observed. A subsequent Phase IIb clinical trial was discontinued after an interim analysis, and these results showed that further intense research on BAK-based therapies for acute renal failure was required. Development of BAK-based therapies for the treatment of patients suffering from end-stage renal disease is even more challenging, and related problems and research approaches are discussed herein, along with the development of mobile, portable, wearable and implantable devices

A Systematic Survey of Control Techniques and Applications: From Autonomous Vehicles to Connected and Automated Vehicles

Vehicle control is one of the most critical challenges in autonomous vehicles (AVs) and connected and automated vehicles (CAVs), and it is paramount in vehicle safety, passenger comfort, transportation efficiency, and energy saving. This survey attempts to provide a comprehensive and thorough overview of the current state of vehicle control technology, focusing on the evolution from vehicle state estimation and trajectory tracking control in AVs at the microscopic level to collaborative control in CAVs at the macroscopic level. First, this review starts with vehicle key state estimation, specifically vehicle sideslip angle, which is the most pivotal state for vehicle trajectory control, to discuss representative approaches. Then, we present symbolic vehicle trajectory tracking control approaches for AVs. On top of that, we further review the collaborative control frameworks for CAVs and corresponding applications. Finally, this survey concludes with a discussion of future research directions and the challenges. This survey aims to provide a contextualized and in-depth look at state of the art in vehicle control for AVs and CAVs, identifying critical areas of focus and pointing out the potential areas for further exploration