22 research outputs found
Symmetrical Skin Lesions on the Gluteal Region in a Patient with Anti-Laminin-332 Mucous Membrane Pemphigoid
Mucous membrane pemphigoid (MMP), previously
called cicatricial pemphigoid, is a rare subepidermal
immunobullous disorder that primarily affects
the mucous membranes (1,2). MMP is divided
into two major subtypes, anti-BP180-type MMP and
anti-laminin-332 (previously called laminin 5 or epiligrin)
MMP. Anti-laminin-332 MMP is known to be
associated with malignant tumors (3), which may
cause overexpression of autoantibodies and induce
autoimmunity to laminin-332 (4). MMP primarily affects
the mucous membranes, and widespread skin
lesions are rare. In MMP, circumscribed skin lesions
have been previously reported as occurring on the
head, neck, and upper trunk (5). We report a case of
anti-laminin-332 MMP presenting with symmetrical
skin lesions characteristic of MMP on the weightbearing
areas of the gluteal regio
Acrokeratosis neoplastica (Bazex syndrome): Report of two cases and literature review
The skin often reflects the presence of internal diseases. Acrokeratosis neoplastica (Bazex syndrome) is a unique skin manifestation characterized by its erythematous hyperkeratosis with yellowish, adherent scales on the palm, sole, or other acral locations. There is a potentially high association between Bazex syndrome and malignant pathology, especially squamous cell carcinomas (SCC). To date, various skin conditions have been recognized as diagnostic indicators of insidious malignancies. The recognition of paraneoplastic dermatoses has a strong potential for prompt cancer detection and early therapeutic intervention. Here we describe clinical and forensic cases of Bazex syndrome that are associated with SCC of the glottis and lung. Bazex syndrome has been reported to be associated with a variety of cancers in addition to SCC. We review the clinical manifestations of Bazex syndrome and include updated knowledge on disease pathogenesis
High rate of cardiac sarcoidosis presenting with cutaneous plaque type sarcoidosis in §ssup§18§esup§F-fluorodeoxyglucose positron emission tomography-computed tomography: A case series
PublisherINTRODUCTION: Myocardial sarcoidosis is known as a significant complication of sarcoidosis, but Holter electrocardiographic monitoring or echocardiograms might not be sensitive enough to detect cardiac involvement. While gallium scintigraphy has been recommended, 18F-fluorodeoxyglucose positron emission tomography-computed tomography might be more sensitive to detect sarcoidosis.
CASE PRESENTATIONS: This report comprises the cases of 12 Japanese patients. Two were male, and ten were female. Their age range was between 32 and 93 years. The average age of the patients was 63. We found internal involvement of sarcoidosis in eight (89%) of nine patients by positron emission tomography-computed tomography and in two (67%) of three patients by gallium scintigraphy. Myocardial sarcoidosis was detected in four (33%) of twelve patients, and specifically in three (75%) of four facial multiple plaque type sarcoidosis patients.
CONCLUSION: The myocardial lesions detected by positron emission tomography-computed tomography could not be detected with conventional