The effect of resveratrol on sphingosine-1 and oxidative/ nitrosative stress in an experimental heart ischemia reperfusion model

Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups. Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study

Laryngoscopic Examination During the COVID-19 Pandemic: Turkish Voice Speech and Swallowing Disorders Society and Turkish Professional Voice Society Recommendations

COVID-19 is highly transmissible and spreads rapidly in the population. This increases the occupational risk for health care workers. In otolaryngology clinic practice, patients with upper respiratory tract infection symptoms are common. Also, routine head and neck examinations such as oral cavity examination, nasal/nasopharyngeal examination, or video laryngostroboscopic evaluation are highly risky because of the aerosol formation. To emphasize this issue, two leading otolaryngology organizations in Turkey; 'Voice Speech and Swallowing Disorders Society', and 'Professional Voice Society' gathered a task force. This task force aimed to prepare a consensus report that would provide practical recommendations of the safety measurements during routine clinical care of laryngology patients. To fulfill this, universal aim, on the 2nd and 9th of May 2020, two web-based meetings were conducted by 20 expert physicians. This eighteen items list was prepared as an output

Evaluation of the relationship between insulin resistance and 8-iso prostaglandin levels in obesity children

Introduction: The rising rate of childhood obesity and the serious health problems it causes are gaining increasing attention in medical research and health policy. Aim: This study aimed to evaluate the relationship between insulin resistance and the oxidative stress biomarker 8-iso-prostaglandin F2α levels in obese children. Materials and methods: Forty-four children in total (21 boys and 23 girls) aged between 6 and 15 years and diagnosed with obesity who attended the Pediatric Endocrinology Unit between December 2020 and June 21 were enrolled in our study. Forty children (20 boys and 20 girls) without systemic diseases were selected as controls. From the percentile curves determined for Turkish children, percentile values of obese children and control group were calculated based on sex and age. In addition, the insulin resistance values (HOMA-IR) in the homeostasis model were calculated. The relationship between the variables was examined with the Pearson and Spearman correlation tests. Children between the 5th and 85th percentile were defined as the control group, and those above the 95th percentile were defined as the obese group. Systolic and diastolic blood pressure, triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol, fasting blood sugar (glucose), insulin, and 8-iso-PGF2α concentrations were measured in all children included in the study. Results: There were significant differences between the two groups in terms of age, body mass index, and systolic and diastolic blood pressures (p<0.05). Glucose, triglyceride, insulin, 8-iso-PGF2α and HOMA-IR levels were found to be statistically significantly higher in obese children than the levels in the control group (p<0.05). In addition, significant positive correlations were found between insulin levels and glucose, triglyceride and HOMA-IR values in obese patients (p<0.05). In obese children, 8-iso-PGF2α concentrations were found to be statistically significantly higher than those in the control group (p<0.01). ROC analysis had a good diagnostic value for 8-iso-PGF2α where the area under the curve was 1.0. A direct, positive, statistically significant correlation was found between insulin resistance and the 8-iso-PGF2α values (r=0.420, p=0.037). Conclusions: 8-iso-PGF2α concentrations were found to be higher in obese children than in the control group. It was observed that increased insulin resistance raised 8-iso-PGF2α levels. 8-iso-PGF2α is thought to be particularly important for the diagnosis and treatment of these patients, with 99% sensitivity and specificity