Venous Thromboembolism Within Professional American Sport Leagues.

Background: Numerous reports have described players in professional American sports leagues who have been sidelined with a deep vein thrombosis (DVT) or a pulmonary embolism (PE), but little is known about the clinical implications of these events in professional athletes. Purpose: To conduct a retrospective review of injury reports from the National Hockey League (NHL), Major League Baseball (MLB), the National Basketball Association (NBA), and the National Football League (NFL) to take a closer look at the incidence of DVT/PE, current treatment approaches, and estimated time to return to play in professional athletes. Study Design: Descriptive epidemiology study. Methods: An online search of all team injury and media reports of DVT/PE in NHL, MLB, NBA, and NFL players available for public record was conducted by use of Google, PubMed, and SPORTDiscus. Searches were conducted using the professional team name combined with blood clot, pulmonary embolism, and deep vein thrombosis. Results: A total of 55 venous thromboembolism (VTE) events were identified from 1999 through 2016 (NHL, n = 22; MLB, n = 16; NFL, n = 12; NBA, n = 5). Nineteen athletes were reported to have an upper extremity DVT, 15 had a lower extremity DVT, 15 had a PE, and 6 had DVT with PE. Six athletes sustained more than 1 VTE. The mean age at time of VTE was 29.3 years (range, 19-42 years). Mean (±SD) time lost from play was 6.7 ± 4.9 months (range, 3 days to career end). Seven athletes did not return to play. Players with upper extremity DVT had a faster return to play (mean ± SD, 4.3 ± 2.7 months) than those with lower extremity DVT (5.9 ± 3.8 months), PE (10.8 ± 6.8 months), or DVT with PE (8.2 ± 2.6 months) (F = 5.69, P = .002). No significant difference was found regarding time of return to play between sports. Conclusion: VTE in professional athletes led to an average of 6.7 months lost from play. The majority of athletes were able to return to play after a period of anticoagulation or surgery. Those with an upper extremity DVT returned to play faster than those with other types of VTE. Further study is needed to look into modifiable risk factors for these events and to establish treatment and return-to-play guidelines to ensure the safety of these athletes

Management of Elbow Dislocations in the National Football League.

Background: Although much literature exists regarding the treatment and management of elbow dislocations in the general population, little information is available regarding management in the athletic population. Furthermore, no literature is available regarding the postinjury treatment and timing of return to play in the contact or professional athlete. Purpose: To review the clinical course of elbow dislocations in professional football players and determine the timing of return to full participation. Study Design: Case series; Level of evidence, 4. Methods: All National Football League (NFL) athletes with elbow dislocations from 2000 through 2011 who returned to play during the season were identified from the NFL Injury Surveillance System (NFL ISS). Roster position, player activity, use of external bracing, and clinical course were reviewed. Mean number of days lost until full return to play was determined for players with elbow dislocations who returned in the same season. Results: From 2000 to 2011, a total of 62 elbow dislocations out of 35,324 injuries were recorded (0.17%); 40 (64.5%) dislocations occurred in defensive players, 12 (19.4%) were in offensive players; and 10 (16.1%) were during special teams play. Over half of the injuries (33/62, 53.2%) were sustained while tackling, and 4 (6.5%) patients required surgery. A total of 47 (75.8%) players who sustained this injury were able to return in the same season. For this group, the mean number of days lost in players treated conservatively (45/47) was 25.1 days (median, 23.0 days; range, 0.0-118 days), while that for players treated operatively (2/47) was 46.5 days (median, 46.5 days; range, 29-64 days). Mean return to play based on player position was 25.8 days for defensive players (n = 28; median, 21.5 days; range, 3.0-118 days), 24.1 days for offensive players (n = 11; median, 19 days; range, 2.0-59 days), and 25.6 days for special teams players (n = 8; median, 25.5 days; range, 0-44 days). Conclusion: Elbow dislocations comprise less than a half of a percent of all injuries sustained in the NFL. Most injuries occur during the act of tackling, with the majority of injured athletes playing a defensive position. Players treated nonoperatively missed a mean of 25.1 days, whereas those managed operatively missed a mean of 46.5 days

An Experimental Investigation into the Effect of Flap Angles for a Piezo-Driven Wing

This article presents a comparison of results from six degree of freedom force and moment measurements and Particle Image Velocimetry (PIV) data taken on the Air Force Institute of Technology\u27s (AFIT) piezoelectrically actuated, biomimetically designed Hawkmoth, Manduca Sexta, class engineered wing, at varying amplitudes and flapping frequencies, for both trimmed and asymmetric flapping conditions to assess control moment changes. To preserve test specimen integrity, the wing was driven at a voltage amplitude 50% below the maximum necessary to achieve the maximal Hawkmoth total stroke angle. 86 and 65 stroke angles were achieved for the trimmed and asymmetric tests respectively. Flapping tests were performed at system structural resonance, and at 10% off system resonance at a single amplitude, and PZT power consumption was calculated for each test condition. Two-dimensional PIV visualization measurements were taken transverse to the wing planform, recorded at the mid-span, for a single frequency and amplitude setting, for both trimmed and asymmetric flapping to correlate with the 6-DoF balance data. Linear velocity data was extracted from the 2-D PIV imagery at 1/2 and 1 chord locations above and below the wing, and the mean velocities were calculated for four separate wing phases during the flap cycle. The mean forces developed during a flap cycle were approximated using a modification of the Rankine-Froude axial actuator disk model to calculate the transport of momentum flux as a measure of vertical thrust produced during a static hover flight condition. Values of vertical force calculated from the 2-D PIV measurements were within 20% of the 6-DOF force balance experiments. Power calculations confirmed flapping at system resonance required less power than at off resonance frequencies, which is a critical finding necessary for future vehicle design considerations

Changing our brains and minds: exploring the effects of individual differences in bilingual language experience on brain structure, function, and cognition

Current research suggests that bilingualism affects both the structure of the brain and several cognitive processes. However, few studies have specifically examined effects of individual differences in bilingual language use on domain-general control processes and their neural correlates. This thesis project assesses the hypothesis that specific language use factors within the bilingual experience will alter neural activity and plasticity in regions implicated in language/executive control. Three studies are run. The first study is longitudinal, examining effects of long-term linguistic immersion on neural plasticity in highly proficient non-native (L2) speakers of English. Data from this study shows adaptations in brain structure related to increased efficiency of language processing and control and modulated by the length of L2 use prior to the study. The second and third studies are cross-sectional, examining effects of specific language use factors on 1) neural structure and intrinsic functional connectivity and 2) performance and neural activation patterns on executive function tasks. Factors related to duration of L2 use correlate to neurocognitive adaptations suggesting increased efficiency in language control. Factors related to extent of L2 use correlate to neurocognitive adaptations suggesting increased language control demands. Considered together, the data suggest that the brain constantly strives to be maximally effective and efficient in language processing control, which in turn affects domain-general cognitive processes. Crucially, the data highlight the necessity of considering specific, individual language experiences in assessing neurocognitive effects of bilingualism

Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides

CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D). A series of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides have been synthesised using an efficient synthetic route and shown to be potent inhibitors of CYP24A1 (IC50 0.11–0.35 μM) compared with the standard ketoconazole. Molecular modelling using our CYP24A1 homology model showed the inhibitors to fill the hydrophobic binding site, forming key transition metal interaction between the imidazole nitrogen and the haem Fe3+ and multiple interactions with the active site amino acid residues

Detecting biological network organization and functional gene orthologs

SUMMARY: We developed a package TripletSearch to compute relationships within triplets of genes based on Roundup, an orthologous gene database containing >1500 genomes. These relationships, derived from the coevolution of genes, provide valuable information in the detection of biological network organization from the local to the system level, in the inference of protein functions and in the identification of functional orthologs. To run the computation, users need to provide the GI IDs of the genes of interest