Some Aspects of Nutritional and Toxic Liver Injury

Based upon a Dissertation on “Hepatic Cirrhosis” given before the Society on Friday, 31st January 1958.The problem of nutritional liver damage and cirrhosis has been made easier and at the same time more difficult as a result of animal experiments and attempts to apply them to man. The clinical syndromes of nutritional liver injury are best classified according to the method of Sherlock:1. The Tropical and Subtropical Clinical Syndromes—The Kwashiorkor Syndrome.2. Alcoholic Liver Injury.3. Liver Injury caused by Protein Deficiency secondary to other disease.The experiments carried out on rats in the field of nutritional liver damage are well known. For this reason, and also because their aetiological relationship to dietary liver injury in man seems to be limited, a brief resume of these will suffice

Polycythaemia

Though strictly speaking polycythaemia means an increase in all three formed elements in the peripheral blood the term is usually used to describe an increase above normal in the number of circulating red cells per unit volume of blood. The polycythaemia may be relative, due to a fall in the plasma volume, or true or absolute when the total number of red cells in the body, the red cell mass, is increased. Such an increase in the mass of circulating red cells could in theory be produced by a prolongation of the average life span of red cells beyond the normal value of about no days, or by an increased output of red cells by the haemopoietic system. Present evidence indicates that in the majority of true polvcythacinic syndromes, it is the latter which occurs (Pike 1958)

Res Medica, Spring 1958, Volume 1, Number 2

TABLE OF CONTENTSTHE ROYAL MEDICAL SOCIETY TO-DAYTHE CONCEPTUAL BASIS OF MODERN SURGERY: Professor John Bruce, C.B.E., T.D., P. R.C.S.E., F.A.C.S. (HONS.)SOME PATHOLOGICAL ASPECTS OF DISSECTING ANEURYSM: M. J.MacLeanCHANGING FASHIONS IN DIABETES: Professor D. M. Dunlop, B.A., M.D., F. R.C. P. F. , F.R.C.P.OPERA OCCULTA: C. Vaughan RuckleySOME ASPECTS OF NUTRITIONAL AND TOXIC LIVER INJURY: A. W. DellipianiSIR JAMES YOUNG SIMPSON: William L.FordTHE AETIOLOGY OF DISSEMINATED SCLEROSIS: J. G. TurnbullHAZARDS OF RADIATION: Andrew Gun

Res Medica, Spring 1967, Volume V, Number 3

EDITORIALNEUROLOGICAL EXAMINATION: JB Stanton, F.R.C.P.E., F.R.C.P., D.P.M. CIRCULATORY STABILITY: N.C.H. Stott, B.S.c., M.B.Ch.B.          CHANGING CONCEPTS OF THE AETIOLOGY OF DIABETES MELLITUSDIAGNOSTIC PROBLEMPOLYCYTHAEMIA: A. W. DELLIPIANI, M.B., M.R.C.P.E.           THE CONTRIBUTORSRESEARCH TOPIC: N.BAKERELECTRON MICROSCOPY IN GLOMERULONEPHRITIS: M. K. McDONALD, M.B., Ch.B., F.R.C.P.(Ed.)THE STRUCTURE AND FUNCTION OF IMMUNOGLOBULINS: J. A. HABESHAW, B.Sc., M.B., Ch.B.           THE SOCIETYBOOK REVIEW