Dataset for Pilot Randomized Trial to Reduce Urinary Bisphenols in Women With Obesity

Background: Bisphenol exposure is widespread and correlated with diabetes and cardiovascular disease. Previous intervention studies have effectively lowered bisphenol exposure among women of normal-weight. The purpose of this pilot study was to test the hypothesis that a 3-week bisphenol intervention would decrease urinary bisphenol A (BPA) bisphenol S (BPS), and bisphenol F (BPF) in women with obesity. Methods: Thirty women with obesity (31.1 ± 5.6 kg/m2, 21.1 ± 3.1 yrs) were randomly assigned to an intervention or control. The intervention included weekly face-to-face meetings to reduce bisphenol exposures from food, cosmetics, and packaged products. Fasting urinary bisphenols, creatinine, and weight were assessed at study entry and after 3-weeks. Results: From study entry to 3-weeks, there was a significant treatment x time (P0.05) effects on creatinine-corrected urinary BPA, BPF, and weight. Conclusion: In women with obesity, a 3-week intervention decreased urinary BPS concentrations. Future large-scale clinical trials are needed to confirm these result and determine whether intervention reductions in bisphenols positively impact diabetes and cardiovascular disease risk markers