MAGIC Upper Limits for two Milagro-detected, Bright Fermi Sources in the Region of SNR G65.1+0.6

We report on the observation of the region around supernova remnant G65.1+0.6 with the stand-alone MAGIC-I telescope. This region hosts the two bright GeV gamma-ray sources 1FGL J1954.3+2836 and 1FGL J1958.6+2845. They are identified as GeV pulsars and both have a possible counterpart detected at about 35 TeV by the Milagro observatory. MAGIC collected 25.5 hours of good quality data, and found no significant emission in the range around 1 TeV. We therefore report differential flux upper limits, assuming the emission to be point-like (<0.1 deg) or within a radius of 0.3 deg. In the point-like scenario, the flux limits around 1 TeV are at the level of 3 % and 2 % of the Crab Nebula flux, for the two sources respectively. This implies that the Milagro emission is either extended over a much larger area than our point spread function, or it must be peaked at energies beyond 1 TeV, resulting in a photon index harder than 2.2 in the TeV band.Comment: 8 pages, 3 figures, 1 tabl

The pragmatic-semiotic construction of male identities in contemporary advertising of male grooming products

[EN] This article aims to unveil how male identities are constructed in a corpus of male toiletry TV ads through a pragmatic and multimodal analysis of a set of implicit assumptions conveyed about the male participants in the ads. The validity of these assumptions is first empirically tested with a group of 10 male informants and then those implied meanings are bundled into thematic cores for their qualitative and quantitative description. Findings reveal that these ads still rely on stereotypical constructs and traditional discourses of what it takes to be a man. For example, men are invited to consume grooming products but reminded to do it the men's way. Men are also reminded of their sexual power to seduce and attract women with the aid of the product. Likewise, by portraying male ad personae in traditional manly activities while emphasizing their toughness and body strength, or their resourcefulness when faced with challenging situations, the ads portray a rather skewed view of contemporary men, which fails to take into account the myriad roles a modern man can play in contemporary societies.I am really grateful to the reviewers for their insightful comments and also to the editor of the journal.Saz Rubio, MMD. (2019). The pragmatic-semiotic construction of male identities in contemporary advertising of male grooming products. Discourse & Communication. 13(2):192-227. https://doi.org/10.1177/1750481318817621S192227132Alexander, S. M. (2003). Stylish Hard Bodies: Branded Masculinity in Men’s Health Magazine. Sociological Perspectives, 46(4), 535-554. doi:10.1525/sop.2003.46.4.535Attwood, F. (2005). ‘Tits and ass and porn and fighting’. International Journal of Cultural Studies, 8(1), 83-100. doi:10.1177/1367877905050165Rubio, M. D. S. (2018). A multimodal approach to the analysis of gender stereotypes in contemporary British TV commercials: «women and men at work». Poznan Studies in Contemporary Linguistics, 54(2), 185-221. doi:10.1515/psicl-2018-0008Del Saz-Rubio, M. M. (2018). Female identities in TV toiletries ads: A pragmatic and multimodal analysis of implied meanings. Journal of Pragmatics, 136, 54-78. doi:10.1016/j.pragma.2018.07.009Barthel, D. (s. f.). When Men put on Appearances: Advertising and the Social Construction of Masculinity. Men, Masculinity, and the Media, 138-153. doi:10.4135/9781483326023.n10Benwell, B. (2003). Introduction: Masculinity and men’s Lifestyle Magazines. The Sociological Review, 51(1_suppl), 6-29. doi:10.1111/j.1467-954x.2003.tb03600.xBrandth, B. (1995). Rural masculinity in transition: Gender images in tractor advertisements. Journal of Rural Studies, 11(2), 123-133. doi:10.1016/0743-0167(95)00007-aBrandth, B., & Haugen, M. S. (2000). From lumberjack to business manager: masculinity in the Norwegian forestry press. Journal of Rural Studies, 16(3), 343-355. doi:10.1016/s0743-0167(00)00002-4Caldas-Coulthard, C. R., & van Leeuwen, T. (2002). 4. Stunning, shimmering, iridescent. Discourse Approaches to Politics, Society and Culture, 91-108. doi:10.1075/dapsac.2.05calCarrigan, T., Connell, B., & Lee, J. (1985). Toward a new sociology of masculinity. Theory and Society, 14(5), 551-604. doi:10.1007/bf00160017Connell, R. W., & Messerschmidt, J. W. (2005). Hegemonic Masculinity. Gender & Society, 19(6), 829-859. doi:10.1177/0891243205278639Craig, S. (s. f.). Considering Men and the Media. Men, Masculinity, and the Media, 2-7. doi:10.4135/9781483326023.n1An, D., & Kim, S. (2007). Relating Hofstede’s masculinity dimension to gender role portrayals in advertising. International Marketing Review, 24(2), 181-207. doi:10.1108/02651330710741811Dick, A., Chakravarti, D., & Biehal, G. (1990). Memory-Based Inferences during Consumer Choice. Journal of Consumer Research, 17(1), 82. doi:10.1086/208539Feasey, R. (2009). Spray more, get more: masculinity, television advertising and the Lynx effect. Journal of Gender Studies, 18(4), 357-368. doi:10.1080/09589230903260027Featherstone, M. (s. f.). The Body in Consumer Culture. The Body: Social Process and Cultural Theory, 170-196. doi:10.4135/9781446280546.n6Firat, A. F., & Venkatesh, A. (1993). Postmodernity: The age of marketing. International Journal of Research in Marketing, 10(3), 227-249. doi:10.1016/0167-8116(93)90009-nFollo, G. (2002). A hero’s journey: young women among males in forestry education. Journal of Rural Studies, 18(3), 293-306. doi:10.1016/s0743-0167(02)00006-2Franzoi, S. L. (1995). The body-as-object versus the body-as-process: Gender differences and gender considerations. Sex Roles, 33(5-6), 417-437. doi:10.1007/bf01954577Gill, R. (2003). Power and the Production of Subjects: A Genealogy of the New Man and the New Lad. The Sociological Review, 51(1_suppl), 34-56. doi:10.1111/j.1467-954x.2003.tb03602.xGill, R., Henwood, K., & McLean, C. (2005). Body Projects and the Regulation of Normative Masculinity. Body & Society, 11(1), 37-62. doi:10.1177/1357034x05049849Grisot, C. (2017). A quantitative approach to conceptual, procedural and pragmatic meaning: Evidence from inter-annotator agreement. Journal of Pragmatics, 117, 245-263. doi:10.1016/j.pragma.2017.06.020Hakala U (2003) Quantitative and qualitative methods of analysing advertising: Content analysis and semiotics. Series Discussion and Working Papers 5. Turku: Turku School of Economics and Business Administration, p. 51.Hall, M., Gough, B., & Seymour-Smith, S. (2012). «I’m METRO, NOT Gay!»: A Discursive Analysis of Men’s Accounts of Makeup Use on YouTube. The Journal of Men’s Studies, 20(3), 209-226. doi:10.3149/jms.2003.209Halliwell, E., & Dittmar, H. (2003). A Qualitative Investigation of Women’s and Men’s Body Image Concerns and Their Attitudes Toward Aging. Sex Roles, 49(11/12), 675-684. doi:10.1023/b:sers.0000003137.71080.97Hanke, R. (1998). Theorizing Masculinity With/In the Media. Communication Theory, 8(2), 183-201. doi:10.1111/j.1468-2885.1998.tb00217.xHarrison, C. (2008). Real men do wear mascara: advertising discourse and masculine identity. Critical Discourse Studies, 5(1), 55-74. doi:10.1080/17405900701768638Holt, D. B., & Thompson, C. J. (2004). Man-of-Action Heroes: The Pursuit of Heroic Masculinity in Everyday Consumption: Figure 1. Journal of Consumer Research, 31(2), 425-440. doi:10.1086/422120Jackson, P. (1994). Black male: Advertising and the cultural politics of masculinity. Gender, Place & Culture, 1(1), 49-59. doi:10.1080/09663699408721200Kacen, J. J. (2000). Girrrl power and boyyy nature: the past, present, and paradisal future of consumer gender identity. Marketing Intelligence & Planning, 18(6/7), 345-355. doi:10.1108/02634500010348932Kervin, D. (1990). Advertising Masculinity: The Representation of Males in Esquire Advertisements. Journal of Communication Inquiry, 14(1), 51-70. doi:10.1177/019685999001400106Kress, G. (2006). Reading Images. doi:10.4324/9780203619728Lee, D. H., & Olshavsky, R. W. (1995). Conditions and Consequences of Spontaneous Inference Generation: A Concurrent Protocol Approach. Organizational Behavior and Human Decision Processes, 61(2), 177-189. doi:10.1006/obhd.1995.1014Levinson, S. C. (2000). Presumptive Meanings. doi:10.7551/mitpress/5526.001.0001Luyt, R. (2012). Constructing hegemonic masculinities in South Africa: The discourse and rhetoric of heteronormativity. Gender and Language, 6(1). doi:10.1558/genl.v6i1.47McNeill, L. S., & Douglas, K. (2011). Retailing masculinity: Gender expectations and social image of male grooming products in New Zealand. Journal of Retailing and Consumer Services, 18(5), 448-454. doi:10.1016/j.jretconser.2011.06.009McNeill, L. S., & Firman, J. L. (2014). Ideal body image: A male perspective on self. Australasian Marketing Journal (AMJ), 22(2), 136-143. doi:10.1016/j.ausmj.2014.04.001Moeschler, J. (s. f.). 15. Conversational and conventional implicatures. Cognitive Pragmatics. doi:10.1515/9783110214215.405Morrison, T. G., Morrison, M. A., & Hopkins, C. (2003). Striving for bodily perfection? An exploration of the drive for muscularity in Canadian men. Psychology of Men & Masculinity, 4(2), 111-120. doi:10.1037/1524-9220.4.2.111Nixon, S. (1996). Hard Looks. doi:10.1007/978-1-349-61442-4Olivardia, R., Pope, H. G., Borowiecki, J. J., & Cohane, G. H. (2004). Biceps and Body Image: The Relationship Between Muscularity and Self-Esteem, Depression, and Eating Disorder Symptoms. Psychology of Men & Masculinity, 5(2), 112-120. doi:10.1037/1524-9220.5.2.112Pascoe, C. J. (2003). Multiple Masculinities? 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The Language of Cosmetics Advertising. doi:10.1057/978-1-137-55798-8Rohlinger, D. A. (2002). Sex Roles, 46(3/4), 61-74. doi:10.1023/a:1016575909173Rudy, R. M., Popova, L., & Linz, D. G. (2010). The Context of Current Content Analysis of Gender Roles: An Introduction to a Special Issue. Sex Roles, 62(11-12), 705-720. doi:10.1007/s11199-010-9807-1Schroeder, J. E., & Zwick, D. (2004). Mirrors of Masculinity: Representation and Identity in Advertising Images. Consumption Markets & Culture, 7(1), 21-52. doi:10.1080/1025386042000212383Tashakkori, A., & Creswell, J. W. (2007). Editorial: The New Era of Mixed Methods. Journal of Mixed Methods Research, 1(1), 3-7. doi:10.1177/2345678906293042Thompson, C. J., & Hirschman, E. C. (1995). Understanding the Socialized Body: A Poststructuralist Analysis of Consumers’ Self-Conceptions, Body Images, and Self-Care Practices. Journal of Consumer Research, 22(2), 139. doi:10.1086/209441THOMPSON, E. H., & PLECK, J. H. (1986). 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Pragmatics & Cognition, 15(1), 203-225. doi:10.1075/pc.15.1.13wo

Effectiveness of an mHealth intervention combining a smartphone app and smart band on body composition in an overweight and obese population: Randomized controlled trial (EVIDENT 3 study)

Background: Mobile health (mHealth) is currently among the supporting elements that may contribute to an improvement in health markers by helping people adopt healthier lifestyles. mHealth interventions have been widely reported to achieve greater weight loss than other approaches, but their effect on body composition remains unclear. Objective: This study aimed to assess the short-term (3 months) effectiveness of a mobile app and a smart band for losing weight and changing body composition in sedentary Spanish adults who are overweight or obese. Methods: A randomized controlled, multicenter clinical trial was conducted involving the participation of 440 subjects from primary care centers, with 231 subjects in the intervention group (IG; counselling with smartphone app and smart band) and 209 in the control group (CG; counselling only). Both groups were counselled about healthy diet and physical activity. For the 3-month intervention period, the IG was trained to use a smartphone app that involved self-monitoring and tailored feedback, as well as a smart band that recorded daily physical activity (Mi Band 2, Xiaomi). Body composition was measured using the InBody 230 bioimpedance device (InBody Co., Ltd), and physical activity was measured using the International Physical Activity Questionnaire. Results: The mHealth intervention produced a greater loss of body weight (–1.97 kg, 95% CI –2.39 to –1.54) relative to standard counselling at 3 months (–1.13 kg, 95% CI –1.56 to –0.69). Comparing groups, the IG achieved a weight loss of 0.84 kg more than the CG at 3 months. The IG showed a decrease in body fat mass (BFM; –1.84 kg, 95% CI –2.48 to –1.20), percentage of body fat (PBF; –1.22%, 95% CI –1.82% to 0.62%), and BMI (–0.77 kg/m2, 95% CI –0.96 to 0.57). No significant changes were observed in any of these parameters in men; among women, there was a significant decrease in BMI in the IG compared with the CG. When subjects were grouped according to baseline BMI, the overweight group experienced a change in BFM of –1.18 kg (95% CI –2.30 to –0.06) and BMI of –0.47 kg/m2 (95% CI –0.80 to –0.13), whereas the obese group only experienced a change in BMI of –0.53 kg/m2 (95% CI –0.86 to –0.19). When the data were analyzed according to physical activity, the moderate-vigorous physical activity group showed significant changes in BFM of –1.03 kg (95% CI –1.74 to –0.33), PBF of –0.76% (95% CI –1.32% to –0.20%), and BMI of –0.5 kg/m2 (95% CI –0.83 to –0.19). Conclusions: The results from this multicenter, randomized controlled clinical trial study show that compared with standard counselling alone, adding a self-reported app and a smart band obtained beneficial results in terms of weight loss and a reduction in BFM and PBF in female subjects with a BMI less than 30 kg/m2 and a moderate-vigorous physical activity level. Nevertheless, further studies are needed to ensure that this profile benefits more than others from this intervention and to investigate modifications of this intervention to achieve a global effect

Supplement: "Localization and broadband follow-up of the gravitational-wave transient GW150914" (2016, ApJL, 826, L13)

This Supplement provides supporting material for Abbott et al. (2016a). We briefly summarize past electromagnetic (EM) follow-up efforts as well as the organization and policy of the current EM follow-up program. We compare the four probability sky maps produced for the gravitational-wave transient GW150914, and provide additional details of the EM follow-up observations that were performed in the different bands

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study.

Peer reviewe

Localization and Broadband Follow-up of the Gravitational-wave Transient GW150914

A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams. </p

Multi-messenger Observations of a Binary Neutron Star Merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ∼ 1.7 {{s}} with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of {40}-8+8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 {M}ȯ . An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ∼ 40 {{Mpc}}) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ∼10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ∼ 9 and ∼ 16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta.</p

Coordinated responses of mitochondrial antioxidative enzymes, respiratory pathways and metabolism in Arabidopsis thaliana thioredoxin trxo1 mutants under salinity

Plant cells suffer alterations of their redox state and increase mitochondrial ROS generation during salinity. To avoid this, they activate several mitochondrial antioxidant and redox systems including the alternative oxidase (AOX), superoxide dismutase (SOD) and the ascorbate-glutathione (ASC-GSH) cycle components in a coordinated manner. The redox-sensitive mitochondrial thioredoxin (Trx) system may be responsible for this coordination through the redox regulation of target proteins. On top of this, metabolic perturbations induced by salinity may lead to alterations of the redox state of the Trx system. In order to explore the association between redox and metabolic changes occurring in mitochondria under saline conditions, we analyzed the salt-stress responses of mitochondrial antioxidant systems and metabolism in wild type (WT) and two knock-out (KO) AtTrxo1 lines. The activities of Mn-SOD and components of the ASC-GSH cycle were determined in isolated mitochondria, together with an evaluation of the AOX redox state, the oxidative stress, and catalase activity. Moreover, the in vivo activities of cytochrome (COX) and alternative mitochondrial respiratory pathways and primary metabolites profile were determined. Our results show that the lack of Trxo1 neither resulted in oxidative stress at the mitochondrial level nor in an upregulation of the antioxidant enzymes under salinity, although glutathione reductase (GR) maintained its high constitutive level as observed in control conditions. Moreover, the AOX was found invariably in its reduced monomeric state and displayed a reduction of its in vivo activity in all genotypes after the salt treatment, probably due to the mild severity of the treatment. Interestingly, trxo1 mutants displayed altered patterns in AOX isoforms and in the activities of the ASC-GSH cycle components and the electron partitioning to the AOX pathway indicating a reorganization of the different antioxidant systems. Furthermore, decreases on glucose and fructose levels in both trxo1 mutants coincided with an increased respiration through the COX pathway under control conditions. All these changes collaborate to maintain a low oxidative stress and the energy demand in both, control and salinity conditions and reflect the acclimation of all the genotypes to the applied stress

Biological nitrogen fixation improves production of ATP and nitrogen status in Lotus japonicus

1 página - Poster presentado en Iberian Plant Biology 2023. XVIII Portuguese-Spanish Congress on Plant Biology and the XXV Meeting of the Spanish Society of Plant Biology. 9-12 Julio 2023, Braga, Portugal.There is a lack of studies unravelling the effect of legume‐rhizobia interactions on plant respiratory energy efficiency. In plants, the existence of the alternative oxidase pathway (AOP) in the mETC confers metabolic flexibility by regulating the dissipation of reducing equivalents from TCA cycle, helping to maintain redox status and nutrient balance but decreasing yield of respiration. It is thought that carbon requirements of the symbiont and nitrogen transfer to the plant from nodules may affect the activities of both cytochrome oxidase pathway (COP) and AOP in plant organs for the benefit of plant yield in N poor soils. The main objective of this research was to create different plant N status by growing plants of WT Lotus japonicus at 5 mM and 10 mM KNO3, and in symbiosis with Mesorhizobium meliloti (0 mM KNO3). Besides, plants displaying spontaneous nodule formation (snf) mutations were grown at 1 mM KNO3. By isotope‐ratio mass spectrometry, we evaluated discrimination against 18O during respiration, and δ13C and δ14N in plant organs to determine ATP synthesis, changes in plant C economy, and N transfer from nodules. By high‐performance liquid chromatography (HPLC) and inductively coupled plasma (ICP) spectrometry, we also determined the content of NADH and nutrients as proxies of changes in TCA cycle activity and in plant nutrient economy. Our results indicated that nitrogen is vital in the modulation of respiratory metabolism, and that symbiosis improves production of ATP via COP, probably due to an incremented photosynthetic demand of symbiont for inorganic carbon and improved N status. Overall, our results shed some light into the complexity of legume‐rhizobia interactions involving plant respiration and essential plant nutrients