Distribution of fast radio burst dispersion measures in CHIME/FRB Catalog 1: implications on the origin of FRBs

Recently, CHIME/FRB project published its first fast radio burst (FRB) catalog (hereafter, Catalog 1), which totally contains 536 unique bursts. With the help of the latest set of FRBs in this large-size catalog, we aim to investigate the dispersion measure (DM) or redshift ($z$) distribution of the FRB population, and solution of this problem could be used to clarify the question of FRB origin. In this study, we adopted the M\&E 2018 model, to fit the observed $z$ distribution of FRBs in Catalog 1. In the M\&E 2018 model, we are mostly interested in the $\Phi(z)$ function, i.e., number of bursts per proper time per comoving volume, which is represented by the star formation rate (SFR) with a power-law index $n$. Our estimated value of $n$ is $0.0_{-0.0}^{+0.6}$ ($0.0_{-0.0}^{+2.1}$) at the 68 (95) per cent confidence level, implying that the FRB population evolves with redshift consistent with, or faster than, the SFR. Specially, the consistency of the $n$ values estimated by this study and the SFR provides a potential support for the hypothesis of FRBs originating from young magnetars.Comment: 7 pages, 2 figures, accepted for publication in Astronomy Report

The Mechanism of Downregulated Interstitial Fluid Drainage Following Neuronal Excitation.

The drainage of brain interstitial fluid (ISF) has been observed to slow down following neuronal excitation, although the mechanism underlying this phenomenon is yet to be elucidated. In searching for the changes in the brain extracellular space (ECS) induced by electrical pain stimuli in the rat thalamus, significantly decreased effective diffusion coefficient (DECS) and volume fraction (α) of the brain ECS were shown, accompanied by the slowdown of ISF drainage. The morphological basis for structural changes in the brain ECS was local spatial deformation of astrocyte foot processes following neuronal excitation. We further studied aquaporin-4 gene (APQ4) knockout rats in which the changes of the brain ECS structure were reversed and found that the slowed DECS and ISF drainage persisted, confirming that the down-regulation of ISF drainage following neuronal excitation was mainly attributable to the release of neurotransmitters rather than to structural changes of the brain ECS. Meanwhile, the dynamic changes in the DECS were synchronized with the release and elimination processes of neurotransmitters following neuronal excitation. In conclusion, the downregulation of ISF drainage following neuronal excitation was found to be caused by the restricted diffusion in the brain ECS, and DECS mapping may be used to track the neuronal activity in the deep brain

Acupuncture for chronic, stable angina pectoris and an investigation of the characteristics of acupoint specificity: study protocol for a multicenter randomized controlled trial

BACKGROUND: Chronic stable angina pectoris (CSAP) is a common cardiovascular condition that endangers a patient’s life quality and longevity. As demonstrated in several clinical trials, acupuncture is attested to be effective for CSAP. Current trials are not adequate enough to provide high-quality evidence for clinical decision making, as a result of inadequate methodology design and small sample size. Notably, stark controversy toward acupoint specificity also exists in the clinical acupuncture trials for CSAP. Therefore, we designed the present study as a randomized controlled trial primarily to investigate the effectiveness of acupuncture in addition to routine care among patients with CSAP. Meanwhile, we examined whether acupoint on the disease-affected meridian (DAM) is superior to either acupoint on the non-affected meridian (NAM) or non-acupoint (NA), to further investigate the meridian-based characteristics of acupoint specificity. METHODS/DESIGN: This study was a multicenter, assessor and statistician blinded, randomized controlled trial in China. In this study, 404 participants in sum will be randomly assigned to four groups through central randomization in a 1:1:1:1 ratio. The whole study period is 20 weeks including a 4-week baseline period, a 4-week treatment period and a 12-week follow-up. Participants in the DAM group receive acupuncture stimulation at acupoints on the disease-affected meridian, and three different control groups will undergo acupuncture stimulation at the NAM, the non-acupoint and no intervention respectively, in addition to basic treatment. Participants in the acupuncture groups will receive 12 sessions of acupuncture treatment over 4 weeks, while the wait-listed (WL) group would receive free acupuncture treatment after the completion of the study. The outcome measures in this trial include the frequency of angina attack during 4 weeks as the primary outcome and eight other secondary outcomes. DISCUSSION: This trial will provide new and relatively high-quality evidence in acupuncture treatment for CSAP. Moreover, this trial may further validate the meridian-based characteristics of acupoint specificity by comparing the strength of acupoints on the disease-affected meridian versus that of the non-affected meridian, to further inspire optimization of acupuncture therapy for CSAP. TRIAL REGISTRATION: Clinical Trials.gov NCT0168623

Qualitative Reasoning for Additional Die Casting Applications

If manufacturing incompatibility of a product can be evaluated at the early product design stage, the designers can modify their design to reduce the effect of potential manufacturing problems. This will result in fewer manufacturing problems, less redsign, less expensive tooling, lower cost, better quality, and shorter development time. For a given design, geometric reasoning can predict qualitatively the behaviors of a physical manufacturing process by representing and reasoning with incomplete knowledge of the physical phenomena. It integrates a design with manufacturing processes to help designers simultaneously consider design goals and manufacturing constraints during the early design stage. The geometric reasoning approach can encourage design engineers to qualitatively evaluate the compatibility of their design with manufacturing limitations and requirements

Detection of biological toxicity of haze with algae fluorescence

The comprehensive toxicity of haze cannot be evaluated by evaluating each pollutant separately because haze contains complex components. In order to quickly, accurately and comprehensively evaluate the comprehensive toxicity of haze, Algae chlorophyll fluorescence method is used to assess the biological toxicity. With Chlorella pyrenoidosa and Microcystis aeruginosa used as experiment algae, and the haze in the heating period as the research object, the solution absorption method and membrane weighing method are used to collect the liquid absorption haze and total suspended particles haze (TSP), respectively. The change of fluorescence parameters (Y(Ⅱ), NPQ, qP, ETR, Fv/Fm) of single algae under the stress of the haze absorption liquid and the total suspended particulate matter are detected by water fluorescence detector. The results show that Chlorella pyrenoidosa is more sensitive to exogenous haze exposure, and the fluorescence parameters decreases significantly, especially that the concentration of NPQ decreases by 46.3% and 40.2% under the influence of haze absorption in the two days of heavy pollution, while Microcystis aeruginosa displays obvious characterization only in the interference of total suspended particulate matter leaching solution. Therefore, it is possible that the NPQ parameter of Chlorella pyrenoidosa is selected as an indicator for haze biological toxicity

The Application of Photovoltaic-Electric Spring Technology to Rural Power Grids

Rural power grids are essential for rural development, impacting the lives of farmers, the agricultural economy, and the overall efficiency of agricultural production. To ensure the reliable operation of these grids, finding ways to provide high-quality power is imperative. In recent years, the penetration rate of distributed photovoltaic (PV) in the distribution network has been increasing. When the output of PV and load are not matched, the voltage fluctuation of the network affects the safe and stable operation of the distribution network. In this study, we propose that the stable operation of rural power grids can be achieved by employing a photovoltaic-electric spring (PV-ES) device. A state space model of PV-ES is established and a single PV-ES voltage control method, based on a PI controller, is proposed, taking a rural user household with a monthly power consumption of about 120 access to distributed power supply as an example. We analyzed the device’s effectiveness in addressing voltage fluctuation issues as well as how light intensity impacts its effectiveness. The implementation of the PV-ES device solves the most significant problem faced by rural power grids, namely, the unstable power supply that occurs during peak electricity consumption periods. In addition, the PV-ES device ensures a high-quality electricity consumption experience for consumers

Phytohormones Regulate the Development of Arbuscular Mycorrhizal Symbiosis

Most terrestrial plants are able to form a root symbiosis with arbuscular mycorrhizal (AM) fungi for enhancing the assimilation of mineral nutrients. AM fungi are obligate symbionts that depend on host plants as their sole carbon source. Development of an AM association requires a continuous signal exchange between the two symbionts, which triggers coordinated differentiation of both partners, to enable their interaction within the root cells. The control of the AM symbiosis involves a finely-tuned process, and an increasing number of studies have pointed to a pivotal role of several phytohormones, such as strigolactones (SLs), gibberellic acids (GAs), and auxin, in the modulation of AM symbiosis, through the early recognition of events up to the final arbuscular formation. SLs are involved in the presymbiotic growth of the fungus, while auxin is required for both the early steps of fungal growth and the differentiation of arbuscules. GAs modulate arbuscule formation in a dose-dependent manner, via DELLA proteins, a group of GRAS transcription factors that negatively control the GA signaling. Here, we summarize the recent findings on the roles of these plant hormones in AM symbiosis, and also explore the current understanding of how the DELLA proteins act as central regulators to coordinate plant hormone signaling, to regulate the AM symbiosis

Evaluating the Effectiveness of Conservation on Mangroves: A Remote Sensing-Based Comparison for Two Adjacent Protected Areas in Shenzhen and Hong Kong, China

Mangroves are ecologically important ecosystems and globally protected. The purpose of this study was to evaluate the effectiveness of mangrove conservation efforts in two adjacent protected areas in China that were under the management policies of the Ramsar Convention (Mai Po Marshes Nature Reserve (MPMNR), Hong Kong) and China’s National Nature Reserve System (Futian Mangrove National Nature Reserve (FMNNR), Shenzhen). To achieve this goal, eleven Landsat images were chosen and classified, areal extent and landscape metrics were then calculated. The results showed that: from 1973–2015, the areal extent of mangroves in both reserves increased, but the net change for the MPMNR (281.43 hm2) was much higher than those of the FMNNR (101.97 hm2). In general, the area-weighted centroid of the mangroves in FMNNR moved seaward by approximately 120 m, whereas in the MPMNR, the centroid moved seaward even farther (410 m). Although both reserves saw increased integrality and connectivity of the mangrove patches, the patches in the MPMNR always had higher integrality than those in the FMNNR. We concluded that the mangroves in the MPMNR were more effectively protected than those in the FMNNR. This study may provide assistance to the formulation of generally accepted criteria for remote sensing-based evaluation of conservation effectiveness, and may facilitate the development of appropriate mangrove forest conservation and management strategies in other counties