Association of Paraoxonase-1 Genotype and Phenotype with Angiogram Positive Coronary Artery Disease

Funding Information: This study was supported by Mashhad and Isfahan University of Medical Sciences. The authors would like to thank technicians of Sina, Sadi, Ghaem catheterization laboratory and technicians of Isfahan Alzahra genetics laboratory.Peer reviewedPublisher PD

SUCCESS RATE OF PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION OF CORONARY ARTERIES

Abstract &nbsp;&nbsp; BACKGROUND: Chronic total occlusion of coronary arteries (CTO) remains one of the most challenging lesion subsets in interventional cardiology even with the development of medical devices and operator expertise. This study sought to determine the overall success rate of percutaneous coronary intervention (PCI) for this lesion in the center and to examine the relationship between variables such as patients&rsquo; characteristics, clinical risk factors, lesion characteristics and procedural success rate. &nbsp;&nbsp; METHODS: Clinical and coronary angiographic data of 58 patients with CTO who underwent PCI between May 2004 and November 2006 in Ghaem Hospital were retrospectively analyzed. A P value of less than 0.05 was considered statistically significant. Analyses were performed using the software packages SPSS (11.5 version). &nbsp;&nbsp; RESULTS: In this study, there were 58 CTO lesions in 41 men (70.7%) and 17 women (29.3%) with a mean occlusion time of 5 months. The overall success rate of PCI was 77.6%. There was no significant correlation between the success rate of PCI and the patient&rsquo;s age, sex, clinical risk factors, history of recent MI and duration of occlusion (P &gt; 0.05). The success rate was not affected by target vessel, location of lesion, presence of stump, presence of side branch at the site of occlusion and TIMI flow of artery (P &gt; 0.05). The success rate of PCI was decreased with increase in the length of occlusion and presence of bridging collaterals (P &lt; 0.05).&nbsp; &nbsp;&nbsp; CONCLUSION: The length of occlusion and presence of bridging collaterals affected the success rate adversely. Whereas the patients&rsquo; characteristics, clinical risk factors and other characteristics of coronary artery lesion had no statistically significant effect on success rate of PCI. Despite the technical difficulty of PCI in CTO lesions, this procedure can be done safely with relatively high success rate. &nbsp; &nbsp;&nbsp; Keywords: Chronic total occlusion (CTO), percutaneous coronary intervention (PCI), coronary arteries.</p

Effect of Renal Artery Stenting on Blood Pressure, Glomerular Filtration Rate and Left Ventricular Mass in Hypertensive Patients with Severe Atherosclerotic Renal Artery Stenosis

Background Many small trials showed a significant improvement in blood pressure following renal artery stenting in patients with severe atherosclerotic renal artery stenosis, but data on renal function improvement is more conflicting. Recently, few trials have been conducted to evaluate the effect of this procedure on Left Ventricular Mass (LVM) and Left Ventricular Mass Index (LVMI). Objectives The aim of this study is to determine the effect of renal artery stenting on Blood Pressure, estimated Glomerular Filtration Rate (eGFR), Left Ventricular Mass (LVM), and Left Ventricular Mass Index (LVMI) in patients with severe atherosclerotic renal artery stenosis. Methods This is a prospective interventional study performed on forty patients with ischemic heart disease and medication resistant hypertension, who had severe (≥ 70%) atherosclerotic renal artery stenosis and underwent renal artery stenting. Blood pressure, LVM, LVMI and eFGR before renal artery stenting and after six months were assessed in these patients. Results There were significant reduction in systolic blood pressure (from 175.50 ± 17.28 mmHg to 137.30 ± 13.21 mmHg) (P < 0.001), and diastolic blood pressure (from 103.45 ± 8.91 mmHg to 84.30 ± 7.33 mmHg) (P < 0.001). Also, there were significant decrease in LVM (from 307.73 ± 108.13 g to 259.34 ± 92.17 g) (P = 0.004) and LVMI (from 174.70 ± 58.26 to 148.01 ± 49.77) (P = 0.004). LVM reduction was independent of SBP and DBP reduction (P = 0.376 and P = 0.196, respectively). Conclusions Renal artery stenting reduces Blood pressure and leads to regression of LVM independent of blood pressure reduction. Regardless of baseline eGFR, our study failed to find a significant increase in glomerular filtration rate

Molecular dynamics, grand canonical Monte Carlo and expert simulations and modeling of water–acetic acid pervaporation using polyvinyl alcohol/tetraethyl orthosilicates membrane

In this study, molecular dynamics (MD) and Monte Carlo (MC) simulations techniques were employed as well as artificial intelligence knowledge of ANFIS and GP to investigate water–acetic acid pervaporation (PV) separation through poly vinylalcohol (PVA)‑silicone based membranes under a wide range of experimental conditions. For the first time, three new optimization algorithms, namely ant colony optimization for continuous domains (ACO), differential evolution (DE) and genetic algorithm (GA) were employed for improving ANFIS modeling. The GP creates a mathematical function or model for the estimation of pervaporation separation index (PSI) as a function of the input variables. ACO-ANFIS and GA-ANFIS and GP had high accuracy (R = 0.9831, 0.9792 and 0.9722, respectively) but DE-ANFIS had a lower accuracy (R = 0.9610) as compared to other models. On the other hand, molecular simulation methods were used and the results of all simulation models were compared fairly to each other and to the experimental results of the literature. Also, some characterizations were taking place to investigate the characteristics of the simulated membranes with MS such as WAXD, and FFV and glass transition temperature was used to estimate the thermal properties of the simulated membranes

A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease

OBJECTIVE To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and pro-oxidant-antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS). DESIGN Subjects (n=243) were classified into MS+ (n=161) and MS- (n=82) subgroups, based on the AHA/NHBLI criteria. RESULTS Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS- group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole. CONCLUSION The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone