26 research outputs found

    The dorsal rat flap: a discussion of the model and the salutary effect of cimetidine on flap survival.

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    Failure of skin flaps remains a significant clinical problem. The dorsal rat flap, a reliable experimental model, was used to test the efficacy of cimetidine in treating a failing flap. Flaps were elevated in 45 rats divided into three equal groups. Group 1 was a saline control group, Group 2 received cimetidine 250 mg/kg three times a day for 7 days postoperatively, and Group 3 received cimetidine for 1 day before surgery, and then as in Group 2. Necrosis was assessed on the seventh postoperative day. Group 2 had 31.1 +/- 1.3 (mean % +/- SEM) necrosis, significantly better than saline control animals (p less than 0.01) and pretreated animals (p less than 0.05). These results suggest the usefulness of cimetidine in ischemic flap surgery

    Sustainable Careers, Vulnerability, and Well-Being: Towards an Integrative Approach

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    Career landscapes have changed over the recent decades with a de-standardization of career paths. Globalization, more flexible labor markets, and new ways of working are just a few of the many factors that erode the boundaries of a well-defined career path. Today, many workers are thus confronted by the vulnerability paradox, where diverse career opportunities and an emphasis on personal agency carry a share of uncertainty, inequity, and pressure to keep fit at all times. This chapter discusses the idea of sustainable careers as an antipode to occupational vulnerabilities in the modern world of work. Indeed, promoting sustainability in flexible and deregulated labor markets can be very difficult. However, this sustainability is necessary to promote employees’ well-being. To elaborate these crucial challenges, we will develop an integrative theoretical approach encompassing both micro- and macro-level factors that may influence occupational trajectories and workplace experiences
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